The TRIad Multi-Marker (TRIMM) program performs max_Z2, and sum_log(P) tests, association tests for a child's or mother's genetic effects using multiple markers from triad families. Statistical significance is evaluated via permutation. It also outputs the nominated risk-haplotype-tagging alleles. For details, see Shi M, Umbach DM ,Weinberg CR "Identification of Risk-related Haplotypes Using Multiple SNPs from Nuclear Families".
trimm.zip (27KB) is the ZIPPED set of the following 5 files:
- R source code: TRIMM.r
- Program documentation: TRIMM_Documentation.pdf
- 3 Example files: geno.m geno.f geno.c