Health Assessment and Translation
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Hui Shan A. Wang, Ph.D.
Health Scientist -
Tel 984-287-3206
[email protected] -
P.O. Box 12233Mail Drop K2-14Durham, NC 27709
Amy Wang, Ph.D., is a health scientist in the Health Assessment and Translation group in the National Toxicology Program (NTP). Wang is the project lead for ORoC monograph of antimony, and provides scientific input on the mechanistic and toxicological aspects of other ORoC or Office of Health Assessment and Translation projects. She also contributes to computational and predictive toxicology activities in NTP.
Wang has been interested in the mechanisms of carcinogenesis, and active in health hazard assessment and alternative testing strategies, ranging from in silico, to in vitro, to non-mammalian approaches. She has published more than 15 peer-reviewed journal articles, and contributed to several U.S. Environmental Protection Agency (EPA) and Organization for Economic Co-operation and Development (OECD) documents. She also has given many talks.
Wang received her B.V.M. (equivalent to doctor of veterinary medicine in the U.S.) from National Taiwan University in Taipei, Taiwan, and practiced as a small animal clinician. Wang received a M.S. in veterinary medicine and a Ph.D. in toxicology, both from Virginia-Maryland Regional College of Veterinary Medicine, part of Virginia Polytechnic Institute and State University. She was awarded an Oak Ridge Institute for Science and Education fellowship and served as a postdoctoral research fellow on nanomaterial risk assessment at the National Center for Environmental Assessment at the U.S. EPA. She later did a postdoctoral research fellowship on high-throughput screening of diverse nanomaterials’ bioactivities, as a part of ToxCast, at the National Center for Computational Toxicology at the U.S. EPA. She then worked at Syngenta as a toxicologist before joining the NTP in 2017.
Recent Publications
- DeMarini D, Chiu W, Guyton K, Gwinn W, Reisfeld B, Wang A, de Conti A, Schubauer-Berigan M, Madia F. Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'". Environmental health perspectives. 2025 Apr 01 [Epub ahead of print]. [ AbstractDeMarini D, Chiu W, Guyton K, Gwinn W, Reisfeld B, Wang A, de Conti A, Schubauer-Berigan M, Madia F. Response to "Comment on 'IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards'". Environmental health perspectives. 2025 Apr 01 ]
- DeMarini D, Gwinn W, Watkins E, Reisfeld B, Chiu W, Zeise L, Barupal D, Bhatti P, Cross K, Dogliotti E, Fritz J, Germolec D, Andersen M, Guyton K, Jinot J, Phillips D, Reddel R, Rothman N, van den Berg M, Vermeulen R, Vineis P, Wang A, Whelan M, Ghantous A, Korenjak M, Zavadil J, Herceg Z, Perdomo S, Dossus L, Chittiboyina S, Cuomo D, Kaldor J, Pasqual E, Rigutto G, Wedekind R, Facchin C, El Ghissassi F, de Conti A, Schubauer-Berigan M, Madia F. IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards. Environmental health perspectives. 2025 Feb;133(2):25001. [ AbstractDeMarini D, Gwinn W, Watkins E, Reisfeld B, Chiu W, Zeise L, Barupal D, Bhatti P, Cross K, Dogliotti E, Fritz J, Germolec D, Andersen M, Guyton K, Jinot J, Phillips D, Reddel R, Rothman N, van den Berg M, Vermeulen R, Vineis P, Wang A, Whelan M, Ghantous A, Korenjak M, Zavadil J, Herceg Z, Perdomo S, Dossus L, Chittiboyina S, Cuomo D, Kaldor J, Pasqual E, Rigutto G, Wedekind R, Facchin C, El Ghissassi F, de Conti A, Schubauer-Berigan M, Madia F. IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards. Environmental health perspectives. 2025 Feb ]
- Taylor K, Howdeshell K, Singh A, Walker V, Wang A, Boyles A, Beverly B, Rooney A. Comment on "Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution". Environmental health perspectives. 2024 Aug;132(8):88001. [ AbstractTaylor K, Howdeshell K, Singh A, Walker V, Wang A, Boyles A, Beverly B, Rooney A. Comment on "Evidence Synthesis of Observational Studies in Environmental Health: Lessons Learned from a Systematic Review on Traffic-Related Air Pollution". Environmental health perspectives. 2024 Aug ]
- Mansouri K, Taylor K, Auerbach S, Ferguson S, Frawley R, Hsieh J, Jahnke G, Kleinstreuer N, Mehta S, Moreira-Filho J, Parham F, Rider C, Rooney A, Wang A, Sutherland V. Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity. Environmental health perspectives. 2024 Aug;132(8):85002. [ AbstractMansouri K, Taylor K, Auerbach S, Ferguson S, Frawley R, Hsieh J, Jahnke G, Kleinstreuer N, Mehta S, Moreira-Filho J, Parham F, Rider C, Rooney A, Wang A, Sutherland V. Unlocking the Potential of Clustering and Classification Approaches: Navigating Supervised and Unsupervised Chemical Similarity. Environmental health perspectives. 2024 Aug ]
- Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, Darst B, Sheng X, Xu Y, Chou A, Benlloch S, Dadaev T, Brook M, Plym A, Sahimi A, Hoffman T, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X, Biobank Japan Project, Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury P, Schleutker J, Tammela T, Sipeky C, Auvinen A, Giles G, Southey M, MacInnis R, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch C, Cho K, Mcmahon B, Neal D, Donovan J, Hamdy F, Martin R, Nordestgaard B, Nielsen S, Weischer M, Bojesen S, Røder A, Stroomberg H, Batra J, Chambers S, Horvath L, Clements J, Tilly W, Risbridger G, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning A, Ghoussaini M, Travis R, Key T, Riboli E, Park J, Sellers T, Lin H, Albanes D, Weinstein S, Cook M, Mucci L, Giovannucci E, Lindstrom S, Kraft P, Hunter D, Penney K, Turman C, Tangen C, Goodman P, Thompson I, Hamilton R, Fleshner N, Finelli A, Parent M, Stanford J, Ostrander E, Koutros S, Beane Freeman L, Stampfer M, Wolk A, Håkansson N, Andriole G, Hoover R, Machiela M, Sørensen K, Borre M, Blot W, Zheng W, Yeboah E, Mensah J, Lu Y, Zhang H, Feng N, Mao X, Wu Y, Zhao S, Sun Z, Thibodeau S, McDonnell S, Schaid D, West C, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel A, Drake B, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou Y, John E, Grindedal E, Maehle L, Khaw K, Ingles S, Stern M, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein B, Kerns S, Ostrer H, Teixeira M, Paulo P, Brandão A, Watya S, Lubwama A, Bensen J, Butler E, Mohler J, Taylor J, Kogevinas M, Dierssen-Sotos T, Castaño-Vinyals G, Cannon-Albright L, Teerlink C, Huff C, Pilie P, Yu Y, Bohlender R, Gu J, Strom S, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach R, Brenner H, Chen X, Holleczek B, Schöttker B, Klein E, Hsing A, Kittles R, Murphy A, Logothetis C, Kim J, Neuhausen S, Steele L, Ding Y, Isaacs W, Nemesure B, Hennis A, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo S, Newcomb L, Lin D, Fowke J, Neslund-Dudas C, Rybicki B, Gamulin M, Lessel D, Kulis T, Usmani N, Abraham A, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao J, Martinez M, Larkin S, Townsend P, Aukim-Hastie C, Bush W, Aldrich M, Crawford D, Srivastava S, Cullen J, Petrovics G, Casey G, Wang Y, Tettey Y, Lachance J, Tang W, Biritwum R, Adjei A, Tay E, Truelove A, Niwa S, Yamoah K, Govindasami K, Chokkalingam A, Keaton J, Hellwege J, Clark P, Jalloh M, Gueye S, Niang L, Ogunbiyi O, Shittu O, Amodu O, Adebiyi A, Aisuodionoe-Shadrach O, Ajibola H, Jamda M, Oluwole O, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Diop H, Gundell S, Roobol M, Jenster G, van Schaik R, Hu J, Sanderson M, Kachuri L, Varma R, McKean-Cowdin R, Torres M, Preuss M, Loos R, Zawistowski M, Zöllner S, Lu Z, Van Den Eeden S, Easton D, Ambs S, Edwards T, Mägi R, Rebbeck T, Fritsche L, Chanock S, Berndt S, Wiklund F, Nakagawa H, Witte J, Gaziano J, Justice A, Mancuso N, Terao C, Eeles R, Kote-Jarai Z, Madduri R, Conti D, Haiman C. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature genetics. 2023 Dec;55(12):2065-2074. [ AbstractWang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, Darst B, Sheng X, Xu Y, Chou A, Benlloch S, Dadaev T, Brook M, Plym A, Sahimi A, Hoffman T, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X, Biobank Japan Project, Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury P, Schleutker J, Tammela T, Sipeky C, Auvinen A, Giles G, Southey M, MacInnis R, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch C, Cho K, Mcmahon B, Neal D, Donovan J, Hamdy F, Martin R, Nordestgaard B, Nielsen S, Weischer M, Bojesen S, Røder A, Stroomberg H, Batra J, Chambers S, Horvath L, Clements J, Tilly W, Risbridger G, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning A, Ghoussaini M, Travis R, Key T, Riboli E, Park J, Sellers T, Lin H, Albanes D, Weinstein S, Cook M, Mucci L, Giovannucci E, Lindstrom S, Kraft P, Hunter D, Penney K, Turman C, Tangen C, Goodman P, Thompson I, Hamilton R, Fleshner N, Finelli A, Parent M, Stanford J, Ostrander E, Koutros S, Beane Freeman L, Stampfer M, Wolk A, Håkansson N, Andriole G, Hoover R, Machiela M, Sørensen K, Borre M, Blot W, Zheng W, Yeboah E, Mensah J, Lu Y, Zhang H, Feng N, Mao X, Wu Y, Zhao S, Sun Z, Thibodeau S, McDonnell S, Schaid D, West C, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel A, Drake B, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou Y, John E, Grindedal E, Maehle L, Khaw K, Ingles S, Stern M, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein B, Kerns S, Ostrer H, Teixeira M, Paulo P, Brandão A, Watya S, Lubwama A, Bensen J, Butler E, Mohler J, Taylor J, Kogevinas M, Dierssen-Sotos T, Castaño-Vinyals G, Cannon-Albright L, Teerlink C, Huff C, Pilie P, Yu Y, Bohlender R, Gu J, Strom S, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach R, Brenner H, Chen X, Holleczek B, Schöttker B, Klein E, Hsing A, Kittles R, Murphy A, Logothetis C, Kim J, Neuhausen S, Steele L, Ding Y, Isaacs W, Nemesure B, Hennis A, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo S, Newcomb L, Lin D, Fowke J, Neslund-Dudas C, Rybicki B, Gamulin M, Lessel D, Kulis T, Usmani N, Abraham A, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao J, Martinez M, Larkin S, Townsend P, Aukim-Hastie C, Bush W, Aldrich M, Crawford D, Srivastava S, Cullen J, Petrovics G, Casey G, Wang Y, Tettey Y, Lachance J, Tang W, Biritwum R, Adjei A, Tay E, Truelove A, Niwa S, Yamoah K, Govindasami K, Chokkalingam A, Keaton J, Hellwege J, Clark P, Jalloh M, Gueye S, Niang L, Ogunbiyi O, Shittu O, Amodu O, Adebiyi A, Aisuodionoe-Shadrach O, Ajibola H, Jamda M, Oluwole O, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Diop H, Gundell S, Roobol M, Jenster G, van Schaik R, Hu J, Sanderson M, Kachuri L, Varma R, McKean-Cowdin R, Torres M, Preuss M, Loos R, Zawistowski M, Zöllner S, Lu Z, Van Den Eeden S, Easton D, Ambs S, Edwards T, Mägi R, Rebbeck T, Fritsche L, Chanock S, Berndt S, Wiklund F, Nakagawa H, Witte J, Gaziano J, Justice A, Mancuso N, Terao C, Eeles R, Kote-Jarai Z, Madduri R, Conti D, Haiman C. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature genetics. 2023 Dec ]