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Health Assessment and Translation

Hui Shan A. Wang, Ph.D.
Hui Shan A. Wang, Ph.D.
Health Scientist
Tel 984-287-3206
[email protected]
P.O. Box 12233
Mail Drop K2-14
Durham, NC 27709

Amy Wang, Ph.D., is a health scientist in the Health Assessment and Translation group in the National Toxicology Program (NTP). Wang is the project lead for ORoC monograph of antimony, and provides scientific input on the mechanistic and toxicological aspects of other ORoC or Office of Health Assessment and Translation projects. She also contributes to computational and predictive toxicology activities in NTP.

Wang has been interested in the mechanisms of carcinogenesis, and active in health hazard assessment and alternative testing strategies, ranging from in silico, to in vitro, to non-mammalian approaches. She has published more than 15 peer-reviewed journal articles, and contributed to several U.S. Environmental Protection Agency (EPA) and Organization for Economic Co-operation and Development (OECD) documents. She also has given many talks.

Wang received her B.V.M. (equivalent to doctor of veterinary medicine in the U.S.) from National Taiwan University in Taipei, Taiwan, and practiced as a small animal clinician. Wang received a M.S. in veterinary medicine and a Ph.D. in toxicology, both from Virginia-Maryland Regional College of Veterinary Medicine, part of Virginia Polytechnic Institute and State University. She was awarded an Oak Ridge Institute for Science and Education fellowship and served as a postdoctoral research fellow on nanomaterial risk assessment at the National Center for Environmental Assessment at the U.S. EPA. She later did a postdoctoral research fellowship on high-throughput screening of diverse nanomaterials’ bioactivities, as a part of ToxCast, at the National Center for Computational Toxicology at the U.S. EPA. She then worked at Syngenta as a toxicologist before joining the NTP in 2017.

Selected Publications

  1. Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. Key Characteristics Approach to Carcinogenic Hazard Identification. Chemical Research in Toxicology 2018 31(12):1290-1292. [Abstract Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. Key Characteristics Approach to Carcinogenic Hazard Identification. Chemical Research in Toxicology 2018 31(12):1290-1292.]
  2. Richter AP, Brown JS, Bharti B, Wang A, Gangwal S, Houck K, Cohen Hubal EA, Paunov VN, Stoyanov SD, Veley OD. 2015. Nanoengineered antimicrobial nanoparticles with environmentally benign cores infused by silver ions. Nature Nanotechnology 10(9):817–823. [Abstract Richter AP, Brown JS, Bharti B, Wang A, Gangwal S, Houck K, Cohen Hubal EA, Paunov VN, Stoyanov SD, Veley OD. 2015. Nanoengineered antimicrobial nanoparticles with environmentally benign cores infused by silver ions. Nature Nanotechnology 10(9):817–823.] 
  3. Wang A, Marinakos S, Badireddy AR, Powers C, and Houck K. 2013. Characterization of physicochemical properties of nanomaterials and nanomaterial immediate environments in high-throughput screening of nanomaterial biological activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 5:430–448. [Abstract Wang A, Marinakos S, Badireddy AR, Powers C, and Houck K. 2013. Characterization of physicochemical properties of nanomaterials and nanomaterial immediate environments in high-throughput screening of nanomaterial biological activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 5:430–448.] 
  4. Nel A, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, DeShazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdorster G, Pinkerton K, Pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A, and Wong J. 2013. A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. ACS Nano 7(8):6422–6433. [Abstract Nel A, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, DeShazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdorster G, Pinkerton K, Pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A, and Wong J. 2013. A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. ACS Nano 7(8):6422–6433.] 
  5. Powers CM, Dana G, Gillespie P, Gwinn MR, Hendren CO, Long TC, Wang A, and Davis JM. 2012. Comprehensive environmental assessment: a meta-assessment approach. Environmental Science & Technology 46(17):9202–9208. [Abstract Powers CM, Dana G, Gillespie P, Gwinn MR, Hendren CO, Long TC, Wang A, and Davis JM. 2012. Comprehensive environmental assessment: a meta-assessment approach. Environmental Science & Technology 46(17):9202–9208.] 
  6. Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials. Series on the Safety of Manufactured Nanomaterials. No. 36. Organisation for Economic Co-operation and Development (OECD), Paris, France, ENV/JM/MONO(2012)40, 2012. [Full Text Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials. Series on the Safety of Manufactured Nanomaterials. No. 36. Organisation for Economic Co-operation and Development (OECD), Paris, France, ENV/JM/MONO(2012)40, 2012.]
  7. U.S. EPA. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-10/081F, 2012. [Abstract U.S. EPA. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-10/081F, 2012.]
  8. Gangwal1 S, Brown JS, Wang A, Houck KA, and Dix DJ. 2011. Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential. Environmental Health Perspectives 119(11):1539–1546. [Abstract Gangwal1 S, Brown JS, Wang A, Houck KA, and Dix DJ. 2011. Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential. Environmental Health Perspectives 119(11):1539–1546.] 
  9. U.S. EPA. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-09/057F, 2010 [Abstract U.S. EPA. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-09/057F, 2010]
  10. Wang A, Kligerman AD, Holladay SD, Wolf DC, and Robertson JL. 2009. Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow. Environmental and Molecular Mutagenesis 50(9):760–770. [Abstract Wang A, Kligerman AD, Holladay SD, Wolf DC, and Robertson JL. 2009. Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow. Environmental and Molecular Mutagenesis 50(9):760–770.] 
  11. Wang A, Wolf DC, Sen B, Knapp GW, Holladay SD, Huckle WR, Caceci T, and Robertson JL. 2009. Dimethylarsinic acid in drinking water changed the morphology of urinary bladder but not the expression of DNA repair genes of bladder transitional epithelium in F344 rats. Toxicologic Pathology 37(4):425–437. [Abstract Wang A, Wolf DC, Sen B, Knapp GW, Holladay SD, Huckle WR, Caceci T, and Robertson JL. 2009. Dimethylarsinic acid in drinking water changed the morphology of urinary bladder but not the expression of DNA repair genes of bladder transitional epithelium in F344 rats. Toxicologic Pathology 37(4):425–437.] 
  12. Wang A, J.L. Robertson JL, S.D. Holladay SD, A.H. Tennant AH, A.J. Lengi AJ, S.A. Ahmed SA, W.R. Huckle WR, and A.D. Kligerman AD. 2007. Measurement of DNA damage in rat urinary bladder transitional cells by the Comet assay: improved procedures for selective harvest of transitional cells and detailed Comet protocols. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 634(1–2):51–59. [Abstract Wang A, J.L. Robertson JL, S.D. Holladay SD, A.H. Tennant AH, A.J. Lengi AJ, S.A. Ahmed SA, W.R. Huckle WR, and A.D. Kligerman AD. 2007. Measurement of DNA damage in rat urinary bladder transitional cells by the Comet assay: improved procedures for selective harvest of transitional cells and detailed Comet protocols. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 634(1–2):51–59.] 
  13. Wang A, Holladay S, Wolf DC, Ahmed SA and Robertson JL. 2006. Reproductive and developmental toxicity of arsenic in rodents: a review. International Journal of Toxicology 25(5):319–331. [Abstract Wang A, Holladay S, Wolf DC, Ahmed SA and Robertson JL. 2006. Reproductive and developmental toxicity of arsenic in rodents: a review. International Journal of Toxicology 25(5):319–331.] 
  14. Sen B, Wang A, S.D. Hester SD, Robertson JL, and Wolf DC. 2005. Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium. Toxicology 215(3):214–226. [Abstract Sen B, Wang A, S.D. Hester SD, Robertson JL, and Wolf DC. 2005. Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium. Toxicology 215(3):214–226.]