Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Necropsy, Histology, Electron Microscopy, Immunohistochemistry, & Imaging Sciences
Ronald A. Herbert, D.V.M., Ph.D., F.I.A.T.P.
Head, Pathology Support Group, Comparative & Molecular Pathogenesis Branch
[email protected]
Research Summary
The Pathology Support Group, within the Comparative & Molecular Pathogenesis Branch, provides technical, collaborative and consultative pathology support for NIEHS research programs. For over 25 years, the Pathology Support Group has been a valuable resource for research programs throughout the NIEHS Division of Intramural Research (DIR) and the Division of Translational Toxicology (DTT). The Group consists of five technical laboratories that are essential components of the DTT and NIEHS research programs.
Our primary mission is to maintain a group of centralized, in-house, pathology Core Laboratories that use the latest technologies to provide a broad range of critical cost effective, routine and specialized, pathology related, technical support for research programs across NIEHS. In addition to technical support, the group also serves as a consultative and collaborative resource for NIEHS scientists related to the technical services provided.
The Group consists of five core laboratories, including:
- Electron Microscopy
- Histology
- Imaging Sciences
- Digital Imaging
- Artificial Intelligence
- lmmunohistochemistry
- Necropsy
The laboratories are staffed by highly experienced, professional, and technical personnel that include board certified, veterinary toxicologic pathologists, technical biologists, and on-site technical contractors.
Ronald Herbert, D.V.M., Ph.D., F.I.A.T.P., leads the Pathology Support Group within the Comparative & Molecular Pathogenesis Branch. He is a veterinary pathologist with over 30 years’ experience in anatomic and diagnostic toxicologic pathology and pathology peer review of short- and long-term rodent toxicity and carcinogenicity studies. Herbert is a graduate of Tuskegee University where he earned Bachelor of Science degrees in Biology, and Animal and Poultry Science, and a Doctor of Veterinary Medicine (D.V.M.) from the Tuskegee University College of Veterinary Medicine in 1985. He completed a residency/fellowship and a Ph.D. in anatomic and comparative pathology at the Purdue University School of Veterinary Medicine, graduating in 1991. Subsequently, Herbert completed a 3-year postdoctoral fellowship in toxicologic pathology in the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS) and joined as an NTP staff scientist in 1994. He has authored or co-authored numerous peer-reviewed articles in leading biomedical journals as well as several book chapters and NTP technical reports . His areas of interest include chemical-induced toxicity and carcinogenesis, and toxicologic pathology with emphasis in pathology peer review, and pathology of the respiratory and female reproductive systems, digital pathology and Artificial Intelligence for qualitative and quantitative pathology evaluations and analyses.
Core Laboratory Capabilities
Electron Microsopy
Histology
Imaging Sciences
Immunohistochemistry
Necropsy
Recent Publications
- Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct;128:104812. [ AbstractDunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct ]
- Ton T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice. Archives of toxicology. 2021 Oct;95(10):3171-3190. [ AbstractTon T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice. Archives of toxicology. 2021 Oct ]
- Jiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2021 May 15;206(10):2468-2477. [ AbstractJiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2021 May 15 ]
- Riva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice. Nature genetics. 2020 Nov;52(11):1189-1197. [ AbstractRiva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice. Nature genetics. 2020 Nov ]
- Willard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicologic pathology. 2019 Aug;47(6):665-783. [ AbstractWillard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicologic pathology. 2019 Aug ]