Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
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David M. Crizer, Ph.D.
Chemist
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Tel 984-287-4221
[email protected]
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P.O. Box 12233
Mail Drop E1-05
Durham, NC 27709
David Crizer, Ph.D., is a chemist in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Before joining DTT he completed his doctorate in Analytical Chemistry at the University of North Carolina at Chapel Hill under the direction of Gary Glish. At UNC his dissertation research focused on the use of mass spectrometry, differential ion mobility, and theoretical chemistry to understand novel ion chemistries.
His work at DTT is focused on the development of mass spectrometry-based untargeted metabolomic methods to aid in the screening of potentially toxic substances. His research also includes analytical method development for hepatic clearance assays, specific activity assays, and metabolite profiling assays. Other interests include the investigation of in silico metabolite prediction and how predictions compare to in vitro data.
Crizer obtained his B.S. in Chemistry from James Madison University followed by a Ph.D. in Analytical Chemistry from University of North Carolina at Chapel Hill.
Publications
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Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories.
Toxics.
2024 Sep 14;12(9):.
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AbstractCrizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14
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Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay.
Chemical research in toxicology.
2024 Jun 17;37(6):923-934.
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AbstractSostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay. Chemical research in toxicology. 2024 Jun 17
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Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.
Archives of toxicology.
2024 Apr;98(4):1111-1123.
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AbstractViant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr
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Qu W, Crizer D, DeVito M, Waidyanatha S, Xia M, Houck K, Ferguson S. Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening.
Toxicology in vitro : an international journal published in association with BIBRA.
2021 Jun;73:105109.
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AbstractQu W, Crizer D, DeVito M, Waidyanatha S, Xia M, Houck K, Ferguson S. Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Jun
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Crizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 May 27;181(2):175-186.
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AbstractCrizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27
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