Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Branch
Michael E. Wyde, Ph.D., D.A.B.T., manages and participates in multidisciplinary teams of NIEHS/NTP scientists to develop research programs to address a broad array of toxicological study needs for chemicals selected for study by the National Toxicology Program. This includes the design, analysis, interpretation, and integration of carcinogenicity, reproductive and developmental, genetic, and general toxicology studies. These research programs serve to identify hazards associated with chemical exposure and increase our understanding of the interaction between chemical exposure and the development of disease. These studies are published as NTP Technical Reports and peer-reviewed research papers in scientific journals and provide critical data for use in risk assessment for human exposure.
Wyde serves as the project leader for several chemicals including compounds that are used in consumer products, as food additives, as chemical intermediates, and environmental contaminants. He has a particular interest in chemical mixtures and herbal products, as well the application of dose-response modeling to NTP data for use in risk assessment, such as the determination of Benchmark Doses for carcinogenic and non-carcinogenic responses.
Wyde received a B.S. in biochemistry from North Carolina State University, Raleigh, North Carolina and a Ph.D. in toxicology from the University of North Carolina at Chapel Hill. He completed postdoctoral work at CIIT Centers For Health Research in Research Triangle Park, North Carolina.
Recent Publications
- Wyde M, Capstick M, Hall S, Hooth M, Kuster N, Ladbury J, Roberts G, Shipkowski K, Shockley K, Smith-Roe S, Stout M, Walker N. Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents . 2025 Aug [Epub ahead of print]. [ AbstractWyde M, Capstick M, Hall S, Hooth M, Kuster N, Ladbury J, Roberts G, Shipkowski K, Shockley K, Smith-Roe S, Stout M, Walker N. Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents . 2025 Aug ]
- Smith-Roe S, Wyde M, Stout M, Winters J, Hobbs C, Shepard K, Green A, Kissling G, Shockley K, Tice R, Bucher J, Witt K. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environmental and molecular mutagenesis. 2020 Feb;61(2):276-290. [ AbstractSmith-Roe S, Wyde M, Stout M, Winters J, Hobbs C, Shepard K, Green A, Kissling G, Shockley K, Tice R, Bucher J, Witt K. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environmental and molecular mutagenesis. 2020 Feb ]
- Wyde M, Horn T, Capstick M, Ladbury J, Koepke G, Wilson P, Kissling G, Stout M, Kuster N, Melnick R, Gauger J, Bucher J, McCormick D. Effect of cell phone radiofrequency radiation on body temperature in rodents: Pilot studies of the National Toxicology Program's reverberation chamber exposure system. Bioelectromagnetics. 2018 Apr;39(3):190-199. [ AbstractWyde M, Horn T, Capstick M, Ladbury J, Koepke G, Wilson P, Kissling G, Stout M, Kuster N, Melnick R, Gauger J, Bucher J, McCormick D. Effect of cell phone radiofrequency radiation on body temperature in rodents: Pilot studies of the National Toxicology Program's reverberation chamber exposure system. Bioelectromagnetics. 2018 Apr ]
- Mercado-Feliciano M, Herbert R, Wyde M, Gerken D, Hejtmancik M, Hooth M. Pyrogallol-associated dermal toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice. Cutaneous and ocular toxicology. 2013 Sep;32(3):234-40. [ AbstractMercado-Feliciano M, Herbert R, Wyde M, Gerken D, Hejtmancik M, Hooth M. Pyrogallol-associated dermal toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice. Cutaneous and ocular toxicology. 2013 Sep ]
- Boyle M, Crabbs T, Wyde M, Painter J, Hill G, Malarkey D, Lieuallen W, Nyska A. Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. Toxicologic pathology. 2012 Jun;40(4):561-76. [ AbstractBoyle M, Crabbs T, Wyde M, Painter J, Hill G, Malarkey D, Lieuallen W, Nyska A. Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. Toxicologic pathology. 2012 Jun ]