Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Branch
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Nigel J. Walker, Ph.D.
Staff Scientist
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Tel 984-287-3204
Fax 301-451-5596
[email protected]
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P.O. Box 12233
Mail Drop K2-02
Durham, NC 27709
Nigel Walker, Ph.D., D.A.B.T., is a staff scientist in the Systems Toxicology Branch, in the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH).
Walker leads the federal interagency Office of National Toxicology Program (NTP) Scientific Operations and Coordination (ONSOC) and in that role provides senior level scientific leadership and direction for the planning, implementation, management, and coordination of research activities of the National Toxicology Program (NTP). The NTP is a Federal interagency program that generates, interprets, and shares toxicological information about potentially hazardous substances in our environment to provide the scientific basis for programs, activities, and policies that promote health or lead to the prevention of disease.
Walker has been at the NIEHS for over 25 years and during this time has led numerous initiatives understanding the potential toxicity and carcinogenicity of compounds under investigation by NTP including nanoscale materials, dioxin-like compounds, persistent organic pollutants, environmental/occupational mixtures, endocrine disrupting compounds, and botanical dietary supplements.
Walker has co-authored over 200 publications, including over 100 peer-reviewed technical reports on the toxicity and carcinogenicity of compounds studied by NTP.
He received his B.Sc. in Biochemistry from the University of Bath in the U.K. and his Ph.D. in Biochemistry from the University of Liverpool, U.K. and has been board certified as a toxicologist by the American Board of Toxicology since 2007.
Recent Publications
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Fitch S, Blanchette A, Haws L, Franke K, Ring C, DeVito M, Wheeler M, Walker N, Birnbaum L, Van Ede K, Antunes Fernandes E, Wikoff D. Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds.
Regulatory toxicology and pharmacology : RTP.
2024 Feb;147:105571.
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AbstractFitch S, Blanchette A, Haws L, Franke K, Ring C, DeVito M, Wheeler M, Walker N, Birnbaum L, Van Ede K, Antunes Fernandes E, Wikoff D. Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds. Regulatory toxicology and pharmacology : RTP. 2024 Feb
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Hamm J, Hsieh J, Roberts G, Collins B, Gorospe J, Sparrow B, Walker N, Truong L, Tanguay R, Dyballa S, Miñana R, Schiavone V, Terriente J, Weiner A, Muriana A, Quevedo C, Ryan K. Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology's (SEAZIT's) Evaluation of Developmental Toxicity.
Toxics.
2024 Jan 22;12(1):.
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AbstractHamm J, Hsieh J, Roberts G, Collins B, Gorospe J, Sparrow B, Walker N, Truong L, Tanguay R, Dyballa S, Miñana R, Schiavone V, Terriente J, Weiner A, Muriana A, Quevedo C, Ryan K. Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology's (SEAZIT's) Evaluation of Developmental Toxicity. Toxics. 2024 Jan 22
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Wikoff D, Ring C, DeVito M, Walker N, Birnbaum L, Haws L. Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment.
Regulatory toxicology and pharmacology : RTP.
2023 Dec;145:105500.
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AbstractWikoff D, Ring C, DeVito M, Walker N, Birnbaum L, Haws L. Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment. Regulatory toxicology and pharmacology : RTP. 2023 Dec
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Ring C, Blanchette A, Klaren W, Fitch S, Haws L, Wheeler M, DeVito M, Walker N, Wikoff D. A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds.
Regulatory toxicology and pharmacology : RTP.
2023 Sep;143:105464.
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AbstractRing C, Blanchette A, Klaren W, Fitch S, Haws L, Wheeler M, DeVito M, Walker N, Wikoff D. A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds. Regulatory toxicology and pharmacology : RTP. 2023 Sep
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Lanzoni A, Castoldi A, Kass G, Terron A, De Seze G, Bal-Price A, Bois F, Delclos K, Doerge D, Fritsche E, Halldorsson T, Kolossa-Gehring M, Hougaard Bennekou S, Koning F, Lampen A, Leist M, Mantus E, Rousselle C, Siegrist M, Steinberg P, Tritscher A, Van de Water B, Vineis P, Walker N, Wallace H, Whelan M, Younes M. Advancing human health risk assessment.
EFSA journal. European Food Safety Authority.
2019 Jul;17(Suppl 1):e170712.
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AbstractLanzoni A, Castoldi A, Kass G, Terron A, De Seze G, Bal-Price A, Bois F, Delclos K, Doerge D, Fritsche E, Halldorsson T, Kolossa-Gehring M, Hougaard Bennekou S, Koning F, Lampen A, Leist M, Mantus E, Rousselle C, Siegrist M, Steinberg P, Tritscher A, Van de Water B, Vineis P, Walker N, Wallace H, Whelan M, Younes M. Advancing human health risk assessment. EFSA journal. European Food Safety Authority. 2019 Jul
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More Recent Publications from PubMed
NTP Reports
- National Toxicology Program. Toxicology and carcinogenesis study of triclosan administered dermally to B6C3F1/N mice. Natl Toxicol Program Tech Rep Ser. 2024 May;(604):NTP-TR-604. [Abstract]
- National Toxicology Program. Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice. Natl Toxicol Program Tech Rep Ser. 2023 Dec;(603):NTP-TR-603. [Abstract]
- National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Natl Toxicol Program Tech Rep Ser. 2023 Jun;(602):NTP-TR-602. [Abstract]
- National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxic Rep Ser. 2023 Mar;(98):NTP-TOX-98. [Abstract]
- National Toxicology Program. Toxicity studies of sodium metavanadate and vanadyl sulfate administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxic Rep Ser. 2023 Feb;(106):NTP-TOX-106. [Abstract]
More Recent Publications & Reports from PubMed
