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May 2024

The PEGS DREAM Challenge is live.

NIEHS is calling all scientists to dive into an exciting new DREAM Challenge to tackle high cholesterol using data available from the Personalized Environment and Genes Study (PEGS) cohort. For this challenge, NIEHS has partnered with Sage Bionetworks, the originator of DREAM Challenges hosted on their Synapse platform. DREAM Challenges engage the scientific community in collaborative problem-solving to address fundamental biomedical questions.

PEGS DREAM Challenge participants will compete in two tasks. In the first task, Challenge participants will use PEGS data to classify individual risk of high cholesterol. In the second task, participants will submit creative hypotheses about high cholesterol beyond known clinical risk factors. Winners will present their results at a conference and will be first authors on papers describing the results, and all participants have the opportunity to be included as authors in papers describing the Challenge. The submission deadline is August 15, 2024. Winners will be announced on August 31, 2024.

April 2024

Join us for the PEGS Town Hall on April 9, 2024.
Register to attend.

June 2023

PEGS Data Freeze 3.1 is now available and consists of the following:

  • Geospatial data linkage for CDC/ATSDR Environmental Justice Index (EJI)

March 2023

PEGS Virtual Event: Town Hall Forum

PEGS hosted a virtual event on March 28, 2023. Study investigators discussed the name change from EPR to PEGS, the history of the study, provided updates and answered questions.

December 2022

PEGS Data Freeze 3 is now available and consists of the following:

  • Geospatial data linkages from the Modern Era Retrospective analysis for Research and Applications (MERRA-2) project and the CDC/ATSDR Social Vulnerability Index (SVI)
  • The WHO’s Anatomical Therapeutic Chemical (ATC) classification system codes for medication data
  • Incorporation of survey responses from the new demographics form and consolidation of legacy and new variables for gender and sex
  • Quality control of Diabetes Screener Survey, Eczema Screener Survey, Right-not-to-know Cognitive Interview Survey and Right-not-to-know Main Survey to nullify invalid values

November 2021

PEGS Data Freeze 2 is now available and consists of the following:

  • Quality control of Health & Exposure Survey, Exposome A Survey, Exposome B Survey and Demographic and Administrative data to nullify invalid values
  • Additional geocoded participant addresses
  • GIS-based exposure estimates computed from various GIS exposure databases

September 2021

The Environmental Polymorphisms Registry (EPR) has been renamed the Personalized Environment and Genes Study (PEGS) to reflect the expanded scope of the study in terms of data, research and analyses.

PEGS has registered 19,402 North Carolina residents and includes rapidly expanding sets of high-dimensional data that comprise:

  • Responses to a Health and Exposure Survey, Internal Exposome Survey and External Exposome Survey.
  • Electronic health and medical records (EHR and EMR), including International Classification of Diseases (ICD) information.
  • Whole genome sequencing data.
  • Geographic Information Systems (GIS) data.

The large-scale and multi-dimensional data collected from the PEGS allow researchers to dissect the etiology of diseases and identify the collective effects of environment, diet, lifestyle, and genetic factors on human health.


PEGS newsletters provide participants, scientific collaborators and others with an overview of the latest study activities and findings. They can be accessed from the PEGS enrollment website.