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The Molecular Microscopy Consortium allows scientists from NIEHS, the University of North Carolina at Chapel Hill, and Duke University to use single particle cryo-electron microscopy and other tools in molecular microscopy to solve macromolecular structures at the atomic level. Cryo-EM requires smaller quantities of material than other structural methods and is especially suitable for the study of hard to crystallize large macromolecular complexes and membrane proteins.

This video shows how the NIEHS Cryo-EM Facility generates 3D images of large proteins. (3:53)

Background

Types of projects we do:

  • Data collection
  • Specimen preparation
  • Experimental design advice and training
  • Image processing and interpretation

Scientific Staff

Mario J. Borgnia, Ph.D.
Mario J. Borgnia, Ph.D.
Director, Molecular Microscopy Consortium
Tel 984-287-3447
[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Venkata P. Dandey, Ph.D.
Venkata P. Dandey, Ph.D.
Deputy Director, Molecular Microscopy Consortium
Tel 201-558-8099
[email protected]
Mary E. Offner
Mary E. Offner
Fellow - IRTA Postbaccalaureate
Tel 984-287-4737
[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Wyatt A. Peele
Wyatt A. Peele
Fellow - IRTA Postbaccalaureate
Tel 984-287-4657
[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Zachary A. Perrott
Zachary A. Perrott
Fellow - IRTA
Tel 984-287-4657
[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Kedar Sharma, Ph.D.
Kedar Sharma, Ph.D.
Fellow - Visiting
Tel 984-287-4678
[email protected]
P.O. Box 12233
Mail Drop MR-02
Durham, NC 27709