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The Molecular Microscopy Consortium allows scientists from NIEHS, the University of North Carolina at Chapel Hill, and Duke University to use single particle cryo-electron microscopy and other tools in molecular microscopy to solve macromolecular structures at the atomic level. Cryo-EM requires smaller quantities of material than other structural methods and is especially suitable for the study of hard to crystallize large macromolecular complexes and membrane proteins.

https://www.niehs.nih.gov/sites/default/files/research/atniehs/facilities/mmc/img835937.jpg

This video shows how the NIEHS Cryo-EM Facility generates 3D images of large proteins. (3:53)

Background

Types of projects we do:

  • Data collection
  • Specimen preparation
  • Experimental design advice and training
  • Image processing and interpretation

Scientific Staff

Mario J. Borgnia, Ph.D.
Mario J. Borgnia, Ph.D.
Director, Molecular Microscopy Consortium
Tel 984-287-3447
[email protected]
111 Tw Alexander Dr
David P Rall Building
Research Triangle Park, NC 27709
Venkat P. Dandey, Ph.D.
Venkat P. Dandey, Ph.D.
Deputy Director, Molecular Microscopy Consortium
Tel 201-558-8099
[email protected]
Shu Yu Offner
Shu Yu Offner
Fellow - IRTA Postbaccalaureate
Tel 984-287-4737
[email protected]
111 Tw Alexander Dr
David P Rall Building
Research Triangle Park, NC 27709
Wyatt Peele
Wyatt Peele
Fellow - IRTA Postbaccalaureate
Tel 984-287-4657
[email protected]
111 Tw Alexander Dr
David P Rall Building
Research Triangle Park, NC 27709
Mx. Ayil T. Perrott
Mx. Ayil T. Perrott
Fellow - IRTA
Tel 984-287-4657
[email protected]
111 Tw Alexander Dr
David P Rall Building
Research Triangle Park, NC 27709
Kedar Sharma, Ph.D.
Kedar Sharma, Ph.D.
Fellow - Visiting
Tel 984-287-4678
[email protected]
P.O. Box 12233
Mail Drop MR-02
Durham, NC 27709