Synaptic & Developmental Plasticity Group
Recent Publications
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Kendricks D, Sleiman S, Fry S, Stallone J, Bernstein B, Stevanovic K, Aksu L, Alexander G, McCann K, Dudek S, Cushman J. Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus.
Hormones and behavior.
2025 Jul 20;174:105794.
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AbstractKendricks D, Sleiman S, Fry S, Stallone J, Bernstein B, Stevanovic K, Aksu L, Alexander G, McCann K, Dudek S, Cushman J. Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus. Hormones and behavior. 2025 Jul 20
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Harris E, Kandemir B, Jones S, Alexander G, Ward J, Wang T, Proaño S, Xu X, Dudek S. Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1.
Communications biology.
2025 Jul 10;8(1):1037.
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AbstractHarris E, Kandemir B, Jones S, Alexander G, Ward J, Wang T, Proaño S, Xu X, Dudek S. Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1. Communications biology. 2025 Jul 10
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Radzicki D, McCann K, Alexander G, Dudek S. Hippocampal area CA2 activity supports social investigation following an acute social stress.
Molecular psychiatry.
2025 Jun;30(6):2284-2296.
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AbstractRadzicki D, McCann K, Alexander G, Dudek S. Hippocampal area CA2 activity supports social investigation following an acute social stress. Molecular psychiatry. 2025 Jun
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Alexander G, Nikolova V, Stöber T, Gruzdev A, Moy S, Dudek S. Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2025 Feb 05;45(6):.
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AbstractAlexander G, Nikolova V, Stöber T, Gruzdev A, Moy S, Dudek S. Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025 Feb 05
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Alexander G, Nikolova V, Stöber T, Gruzdev A, Moy S, Dudek S. Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory.
bioRxiv : the preprint server for biology.
2024 Nov 08 [Epub ahead of print].
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AbstractAlexander G, Nikolova V, Stöber T, Gruzdev A, Moy S, Dudek S. Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory. bioRxiv : the preprint server for biology. 2024 Nov 08
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More Recent Publications from PubMed
Selected Publications
- Samadi M, Hales CA, Lustberg DJ, Farris S, Ross MR, Zhao M, Hepler JR, Harbin NH, Robinson ESJ, Banks PJ, Bashir ZI, Dudek SM. 2023. Mechanisms of mGluR-dependent plasticity in hippocampal area CA2. Hippocampus. 33(6):730-744. doi: 10.1002/hipo.23529. Epub 2023 Mar 27.PMID: 36971428 [Abstract]
- Carstens KE, Lustberg DJ, Shaughnessy EK, McCann KE, Alexander GM, Dudek SM. 2021. Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome. J Clin Invest 131(16):e137221. [Abstract]
- McCann KE, Lustberg DJ, Shaughnessy EK, Carstens KE, Farris S, Alexander GM, Radzicki D, Zhao M, Dudek SM. 2019. Novel role for mineralocorticoid receptors in control of a neuronal phenotype. Mol Psychiatry; doi: 10.1038/s41380-019-0598-7 [Online 19 November 2019]. [Abstract]
- Farris S, Ward JM, Carstens KE, Samadi M, Wang Y, Dudek SM. 2019. Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2. Cell Rep 29(2):522-539.e6. [Abstract]
- Alexander GM, Riddick NV, McCann KE, Lustberg D, Moy SS, Dudek SM. 2019. Modulation of CA2 Neuronal Activity Increases Behavioral Responses to Fear Conditioning in Female Mice. Neurobiology of Learning and Memory 163:107044. [Abstract]
- Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Jensen P, Dudek SM. 2018. CA2 Neuronal Activity Controls Hippocampal Low Gamma and Ripple Oscillations. eLife doi:10.7554/eLife.38052 [Online 2 November 2018]. [Abstract]
- Tyssowski KM, DeStefino NR, Cho JH, Dunn CJ, Poston RG, Carty CE, Jones RD, Chang SM, Romeo P, Wurzelmann MK, Ward JM, Andermann ML, Saha RN, Dudek SM, Gray JM. 2018. Different Neuronal Activity Patterns Induce Different Gene Expression Programs. Neuron 98(3):530-546. [Abstract]
- Henson MA, Tucker CJ, Zhao M, Dudek SM. 2016. Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning. Neurobiology of learning and memory S1074-7427(16):30282-30289. [Abstract]
- Carstens KE, Phillips ML, Pozzo-Miller L, Weinberg RJ, Dudek SM. 2016. Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons. J Neurosci. 36(23):6312-20. [Abstract]
- Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM. 2016. Social and novel contexts modify hippocampal CA2 representations of space. Nature Communications 7, 10300. [Abstract]
- Dudek SM, Alexander GM, Farris S. 2016. Rediscovering area CA2: unique properties and functions. Nature Reviews Neuroscience 17(2):89-102. [Abstract]
- Simons, S.B., Caruana, D.A., Zhao, M. & Dudek, S.M. 2011. Caffeine-induced synaptic potentiation in hippocampal CA2 neurons. Nature Neuroscience 15(1):23-5. [Abstract]
- Saha, R.N., Wissink, E.M., Bailey, E., Zhao, M., Fargo, D., Hwang, J., Daigle, K.R., Fenn, J.D., Adelman, K. & Dudek, S.M. 2011. Rapid activity-induced transcription of arc and other IEGs relies on poised RNA polymerase II. Nature neuroscience 14(7):848-856. [Abstract]
- Simons, S.B., Escobedo, Y., Yasuda, R. & Dudek, S.M. 2009. Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity. Proceedings of the National Academy of Sciences of the United States of America 106(33):14080-14084. [Abstract]
- Bastrikova, N., Gardner, G.A., Reece, J.M., Jeromin, A. & Dudek, S.M. 2008. Synapse elimination accompanies functional plasticity in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America 105(8):3123-3127. [Abstract]
- Zhao, M. & Dudek, S.M. 2007. Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 27(44):12025-12032. [Abstract]
- Zhao, M., Adams, J.P. & Dudek, S.M. 2005. Pattern-dependent role of NMDA receptors in action potential generation: consequences on Extracellular Signal-Regulated Kinase activation. J. Neurosci. 25, 7032-7039. [Abstract]
- Adams, J.P. & Dudek, S.M. 2005. Late-phase long-term potentiation: getting to the nucleus, Nature Rev. Neurosci. 6, 737-743. [Abstract]
- Dudek, S.M. & Fields, R.D. 2002. Somatic action potentials are sufficient for late-phase LTP-related cell signaling, Proc Natl Acad Sci USA 99(6), 3962-3967. [Abstract]
- Dudek, S.M. & Fields, R.D. 2001. Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: roles of action potentials, frequency, and mode of calcium entry, J Neurosci 21(2), RC122. [Abstract]
- Dudek, S.M. & Friedlander, M.J. 1996. Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition, Neuron 16(6), 1097-1106. [Abstract]
- Dudek, S.M. & Johnson, G.V.W. 1993. Transglutaminase catalyzes the formation of sodium dodecyl sulfate insoluble, Alz-50 positive polymers of tau. J. Neurochem. 61: 1159-1162. [Abstract]
- Dudek, S.M. & Bear, M.F. 1993. Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J. Neurosci. 13: 2910-2918. [Abstract]
- Dudek, S.M. & Bear, M.F. 1992. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 89(10), 4363-4367. [Abstract]
Full List of Publications in MyBibliography