Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Toxicoinformatics Group
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Frank G. Chao, Ph.D.
Computational Biologist
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Tel 984-287-4066
Fax 919-541-3647
[email protected]
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P.O. Box 12233
Mail Drop K2-17
Durham, NC 27709
Frank Chao, Ph.D., is a Computational Biologist in the Predictive Toxicology Branch of the Division of Translational Toxicology (DTT). His primary responsibilities include developing and applying methods to identify relationships between apical toxicological effects and transcriptional responses in target organs. He leverages R’s powerful statistical capabilities and advanced visualization tools to predict metabolic pathways in humans based on rat in vivo microarray expression data, utilizing the Enrichr application.
Before joining DTT in 2019, Chao earned his B.S. in Biology from Peking University in China and his Ph.D. in Toxicology from the University of Missouri at Columbia. He then worked at Duke University Medical Center from 2002 to 2005, focusing on detecting single nucleotide polymorphisms (SNPs). Starting in May 2005, he joined the NIEHS research groups in the Molecular Genetics Core Facility and the Clinical Research Unit (CRU), where he concentrated on pulmonary gene analysis and patient sample data until December 2019.
Recent Publications
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Richter K, Burch L, Chao F, Henke D, Jiang C, Daly J, Zhao M, Kissling G, Diaz M. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.
The Journal of biological chemistry.
2012 Sep 14;287(38):31856-65.
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AbstractRichter K, Burch L, Chao F, Henke D, Jiang C, Daly J, Zhao M, Kissling G, Diaz M. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. The Journal of biological chemistry. 2012 Sep 14
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Burch L, Zhang L, Chao F, Xu H, Drake J. The bacteriophage T4 rapid-lysis genes and their mutational proclivities.
Journal of bacteriology.
2011 Jul;193(14):3537-45.
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AbstractBurch L, Zhang L, Chao F, Xu H, Drake J. The bacteriophage T4 rapid-lysis genes and their mutational proclivities. Journal of bacteriology. 2011 Jul
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Burch L, Yang Y, Sterling J, Roberts S, Chao F, Xu H, Zhang L, Walsh J, Resnick M, Mieczkowski P, Gordenin D. Damage-induced localized hypermutability.
Cell cycle (Georgetown, Tex.).
2011 Apr 01;10(7):1073-85.
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AbstractBurch L, Yang Y, Sterling J, Roberts S, Chao F, Xu H, Zhang L, Walsh J, Resnick M, Mieczkowski P, Gordenin D. Damage-induced localized hypermutability. Cell cycle (Georgetown, Tex.). 2011 Apr 01
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Burch L, Yang I, Whitehead G, Chao F, Berman K, Schwartz D. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment.
American journal of physiology. Lung cellular and molecular physiology.
2006 Oct;291(4):L677-82.
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AbstractBurch L, Yang I, Whitehead G, Chao F, Berman K, Schwartz D. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. American journal of physiology. Lung cellular and molecular physiology. 2006 Oct
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More Recent Publications from PubMed
