NTP Logo

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

Environmental Exposure Assessment and Mechanistically Informed Risk Assessments Using Spatiotemporal Statistics

Kyle P. Messier, Ph.D.
Kyle P. Messier, Ph.D.
Stadtman Investigator;
Leader, Spatiotemporal Exposures and Toxicology
Tel 984-287-3215
[email protected]
530 Davis Dr
530 Davis Drive (Keystone Bldg)
Durham, NC 27713

Research Summary

Spatiotemporal Exposures and Toxicology Group

Spatiotemporal models are a class of statistical models that explicitly account for the spatial and/or temporal correlation in data. They have a rich history in fields such mining, forestry, petroleum engineering , exposure science, and most recently, machine learning and artificial intelligence. Within environmental health sciences, there is an ever-growing need for methodological development and applications of spatiotemporal models that can handle the large, complex data and interdisciplinary challenges. Towards this end, the central theme of the Spatiotemporal Exposures and Toxicology Group (SET) is to develop spatiotemporal methods and applications in environmental and human health exposure science while also exploring innovative applications of geospatial and spatiotemporal methods in toxicology.

Currently, the Spatiotemporal Exposures and Toxicology Group is interested in:

  • Geospatial exposure, disparity, and risk mapping
  • Geospatial mapping of mixture exposure through common molecular initiating events
  • Spatiotemporal mapping connections to toxicology
  • Toxicokinetic and toxicological-based geospatial risk mapping

The group is led by Kyle P. Messier, Ph.D. Messier is a Stadtman Tenure-Track Investigator in the Division of Translational Toxicology (DTT). He also holds a joint appointment with the National Institute of Minority Health and Health Disparities (NIMHD) in Bethesda, Maryland. Messier received a B.S. in Environmental Studies from the University of North Carolina at Asheville and a M.S. and Ph.D. from the University of North Carolina at Chapel Hill. He also holds a secondary appointment in the NIEHS Biostatistics and Computational Biology Branch.

Scientists & Staff

Kyle P. Messier, Ph.D.
Kyle P. Messier, Ph.D.
Stadtman Investigator;
Leader, Spatiotemporal Exposures and Toxicology
Tel 984-287-3215
[email protected]
Mariana A. Kassien, Ph.D.
Mariana A. Kassien, Ph.D.
Fellow - IRTA
Tel 984-287-3215
[email protected]
Eva L. Marques, Ph.D.
Eva L. Marques, Ph.D.
Fellow - Visiting
Tel 984-287-3215
[email protected]
Mitchell E. Manware, M.S
Mitchell E. Manware, M.S
Contractor - Data Analyst
Tel 984-287-3215
[email protected]
Insang Song, Ph.D.
Insang Song, Ph.D.
Fellow - Visiting
Tel 984-287-3215
[email protected]

Selected Publications

Software