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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

The Predictive Toxicology Branch (PTB) partners across the NIEHS Division of Translational Toxicology (DTT) to develop and apply innovative approaches to predict human-relevant health effects from agents of interest to DTT. DTT is a team-based scientific organization, and its mission is to improve public health through development of data and knowledge that are translatable, predictive, and timely.

Capabilities of the Branch include the development, validation, and application of computational tools, dose-response models, and systems toxicology models. The Branch serves as the DTT lead for key partnerships such as the interagency Tox21 Program and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM).

The goals of PTB are carried out by the following groups.

PTB scientists contribute to NTP report and monograph series and publish findings in the NIEHS report series and peer-reviewed scientific literature. Staff publications can be viewed on the webpage.


David M. Reif, Ph.D.
David M. Reif, Ph.D.
Chief, Predictive Toxicology Branch
Tel 984-287-3195
[email protected]
530 Davis Dr
530 Davis Drive (Keystone Bldg)
Durham, NC 27713