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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
The Division of Translational Toxicology’s (DTT) Exposure-based Research Programs aim to solve contemporary public health problems related to environmental exposures.
The intent is to develop and apply novel tools and approaches to better predict potential harm to human health from environmental exposures we encounter at home, at work, and at play.
The following programs make up this strategic area of focus.
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Combined Exposures and Mixtures Program
Humans are continuously exposed to mixtures of chemicals. Challenges continue in characterizing exposure to mixtures, evaluating their toxicity and hazard, and assessing associated risk. Limitations in understanding have led to inconsistent use of available methods to assess mixtures and uncertainties in their application. The lack of harmonized terminology or methods' comparisons complicate the synthesis of information across disciplines and impede the use of mixtures data in decision-making.![](/sites/default/files/research/atniehs/assets/images/consumerproduct_og.jpg)
Consumer Products and Therapeutics Program
People are exposed to numerous chemicals through the use of consumer products. This presents challenges for determining potential adverse human health outcomes, which cannot be done using traditional, single chemical toxicology testing. Therefore, this program aims to define approaches that can address how best to test the large number of chemicals and mixtures of chemicals in consumer products.![](/sites/default/files/research/atniehs/assets/images/occupational_og.jpg)