PI, Institution:
Robert O. Wright, Icahn School of Medicine at Mount Sinai

Grant: R24ES028522

PROGRESS is a longitudinal birth cohort study examining the effects of prenatal exposures to mixtures of metals, air pollution and phthalates on childhood executive function and metabolic outcomes in Mexico. For more information about this cohort, visit the NIEHS Epidemiology Resources webpage for PROGRESS.

Cohort Maintenance & Enrichment Activities:
Expanding follow-up to ages 8–11. Including additional untargeted chemical analysis measures of exposure using shed deciduous teeth, and external environmental exposures using GIS-based models of environmental exposures, including walkability and green space, dating back to conception/pregnancy. Adding some measures of health outcomes, including neurodevelopment via the NIH toolbox during preadolescence. The NIH toolbox allows for harmonization across different studies and different age groups. Exploring the use of social media to engage participants and developing educational materials designed to present healthy messaging to participants about their environment and assessing participant needs to improve retention.

Data Management & Sharing Activities:
Testing methods for data harmonization to allow analyses of complex mixtures and piloting pooling methods with other cohorts of similar design. Preparing PROGRESS for integration with other birth cohorts as larger consortia are formed to address questions about the effects of complex interactions and mixtures across the lifespan.

Data Access:
The data and biospecimens that support the findings of this study are available from the principal investigator upon reasonable request. Please contact Robert Wright.

Please see NIH RePORTER for publications associated with this R24 grant.