Mechanistic Toxicology Branch
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Julie R. Rice
Biologist -
Tel 984-287-4223
[email protected] -
P.O. Box 12233Mail Drop E1-05Durham, NC 27709
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Julie Rice is a biologist in the NIEHS Division of Translational Toxicology (DTT). She focuses on work with the LCMS (liquid chromatography/mass spectrometry) in the Mechanistic Toxicology Branch. Rice extracts and analyzes biological samples, , for targeted and untargeted metabolomics looking at potentially toxic substances. Rice uses the Vanquish Liquid Chromatography instrument and the Q-Exactive Plus and Orbitrap Exploris 240 Mass Spectrometers for her research.
Prior to working with the LCMS, Rice worked in the WormTox group, where she assisted in the development of several bioassays using C. elegans as an alternative model organism in high-throughput toxicological screening. These include assays measuring growth, reproduction, and feeding rates of worms exposed to various toxicants.
Julie received her B.S. from the University of Wisconsin at LaCrosse in 1986. Prior to working at NIEHS, she performed nutrient analysis on water, soil, and plant material at the Duke University Wetland Center in Durham, North Carolina.
Selected Publications
- Crizer DM, Rice JR, Smeltz MG, Lavrich KS, Ravindra K, Wambaugh JF, DeVito M, Wetmore BA. 2024. In-Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) Across Multiple Structural Categories. In review.
- Viant MR, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer DM, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards PEG, Lim PP, Lloyd GR, Mosley J, Namini C, Rice JR, Romano S, Sands C, Smith MJ, Sobanski T, Southam AD, Swindale L, van Ravenzwaay B, Walk T, Weber RJM, Zickgraf FM, Kamp H. 2024. Demonstrating the reliability of in vivo metabolomics based chemical grouping: Towards best practice. Archives of Toxicology 98(4):1111-1123. [Abstract]
- Crizer DM, Ramaiahgari SC, Ferguson SS, Rice JR, Dunlap PE, Sipes NS, Auerbach SS, Merrick BA, DeVito MJ. 2021. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicol Sci 181(2):175-186. [Abstract]
- Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV. 2019. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicol Sci 172(2):316-329. [Abstract]
- Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS. 2019. The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling. Toxicol Sci 169(2):553-566. [Abstract]
- Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, Witt KL, DeVito M, Freedman JH, Austin CP, Houck KA, Thomas RS, Paules RS, Tice RR, Simeonov A. 2018. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environ Health Perspect 126(7):077010. [Abstract]
- Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh J, Freedman JH, Boyd WA. 2016. Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to C. elegans. Toxicological Sciences, doi: 10.1093/toxsci/kfw162. [Abstract Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh J, Freedman JH, Boyd WA. 2016. Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to C. elegans. Toxicological Sciences, doi: 10.1093/toxsci/kfw162.]
- Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH. 2016. Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Environmental health perspectives, 124(5):586-593. [Abstract Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH. 2016. Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Environmental health perspectives, 124(5):586-593.]
- Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol 52(Pt B):181-93. [Abstract]
- Rice JR, Boyd WA, Chandra D, Smith MV, Den Besten PK, Freedman JH. (2013) Comparison of the toxicity of fluoridation compounds in the nematode C. elegans. Environ Toxicol Chem. 2013 Sep 16. doi: 10.1002/etc.2394. [Epub ahead of print] [Abstract Rice JR, Boyd WA, Chandra D, Smith MV, Den Besten PK, Freedman JH. (2013) Comparison of the toxicity of fluoridation compounds in the nematode C. elegans. Environ Toxicol Chem. 2013 Sep 16. doi: 10.1002/etc.2394. [Epub ahead of print]]
- Harrington JM, Boyd WA, Smith MV, Rice JR, Freedman JH, Crumbliss AL. 2012. Amelioration of Metal-Induced Toxicity In Caenorhabditis Elegans: Utility of Chelating Agents in the Bioremediation Of Metals. Toxicological Sciences, 129:49-56 [Abstract Harrington J, Boyd W, Smith M, Rice J, Freedman J, Crumbliss A. 2012. Amelioration of Metal-Induced Toxicity In Caenorhabditis Elegans: Utility of Chelating Agents in the Bioremediation Of Metals. Toxicological Sciences, 129:49-56]
- Boyd WA, McBride SJ, Rice JR, Snyder DW, Freedman JH. 2010. A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. Toxicology and Applied Pharmacology, 245:153-159. [Abstract Boyd WA, McBride SJ, Rice JR, Snyder DW, Freedman JH. 2010. A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. Toxicology and Applied Pharmacology, 245:153-159.]
- Boyd WA, Smith MV, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH. 2009. Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. PLoS ONE, 4(9):e7024. [Abstract Boyd WA, Smith MV, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH. 2009. Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. PLoS ONE, 4(9):e7024.]
- Smith MV, Boyd WA, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH. 2009. A discrete time model for the analysis of medium-throughput C. elegans growth data. PLoS ONE, 4(9):e7018. [Abstract Smith MV, Boyd WA, Kissling GE, Rice JR, Snyder DW, Portier CJ, Freedman JH. 2009. A discrete time model for the analysis of medium-throughput C. elegans growth data. PLoS ONE, 4(9):e7018.]