Mechanistic Toxicology Branch
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Julie R. Rice
Biologist -
Tel 984-287-4223
[email protected] -
P.O. Box 12233Mail Drop E1-05Durham, NC 27709
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Julie Rice is a biologist in the NIEHS Division of Translational Toxicology (DTT). She focuses on work with the LCMS (liquid chromatography/mass spectrometry) in the Mechanistic Toxicology Branch. Rice extracts and analyzes biological samples, , for targeted and untargeted metabolomics looking at potentially toxic substances. Rice uses the Vanquish Liquid Chromatography instrument and the Q-Exactive Plus and Orbitrap Exploris 240 Mass Spectrometers for her research.
Prior to working with the LCMS, Rice worked in the WormTox group, where she assisted in the development of several bioassays using C. elegans as an alternative model organism in high-throughput toxicological screening. These include assays measuring growth, reproduction, and feeding rates of worms exposed to various toxicants.
Julie received her B.S. from the University of Wisconsin at LaCrosse in 1986. Prior to working at NIEHS, she performed nutrient analysis on water, soil, and plant material at the Duke University Wetland Center in Durham, North Carolina.
Recent Publications
- Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14;12(9):. [ AbstractCrizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14 ]
- Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr;98(4):1111-1123. [ AbstractViant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr ]
- Crizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27;181(2):175-186. [ AbstractCrizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27 ]
- Ryan K, Huang M, Ferguson S, Waidyanatha S, Ramaiahgari S, Rice J, Dunlap P, Auerbach S, Mutlu E, Cristy T, Peirfelice J, DeVito M, Smith-Roe S, Rider C. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Dec 01;172(2):316-329. [ AbstractRyan K, Huang M, Ferguson S, Waidyanatha S, Ramaiahgari S, Rice J, Dunlap P, Auerbach S, Mutlu E, Cristy T, Peirfelice J, DeVito M, Smith-Roe S, Rider C. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Dec 01 ]
- Ramaiahgari S, Auerbach S, Saddler T, Rice J, Dunlap P, Sipes N, DeVito M, Shah R, Bushel P, Merrick B, Paules R, Ferguson S. The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun 01;169(2):553-566. [ AbstractRamaiahgari S, Auerbach S, Saddler T, Rice J, Dunlap P, Sipes N, DeVito M, Shah R, Bushel P, Merrick B, Paules R, Ferguson S. The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun 01 ]