Which diseases and exposures are being studied in the PEGS cohort?
In contrast to research studies that focus on a single disease or environmental exposure, PEGS data contains information on a large number of diseases and environmental exposures. The data include questionnaire-based information on exposome-wide environmental exposures, geospatial estimates of exposures, and whole genome sequencing and are linked to electronic health records. This richness and diversity of PEGS data enables researchers to conduct a multitude of studies to address important environmental health questions, understand disease etiology, identify disease risk factors, and improve disease prevention.

Where can I find an overview of PEGS data?
The data components, data snapshots, and the PEGS aggregated data views in Informatics for Integrating Biology and the Bedside (i2b2) application provide overviews of the PEGS data.

How can I access PEGS data?
We welcome collaborative research using the PEGS data. To access and use the PEGS data, you must submit a research concept proposal. Please visit Scientific Collaborations for details.


Who can I contact if I have additional questions?
Please contact us if you have additional questions.

Where can I find information for study participants or enroll in PEGS?
Information for participants is available on the PEGS enrollment website. Enrollment of participants in PEGS is ongoing.

Research Collaborations

How do I submit a research proposal if I want to use PEGS data?
We welcome collaborative research using PEGS data. Please visit Scientific Collaborations for information on submitting a research concept proposal.

Which member of the PEGS Executive Leadership Committee should I contact to initiate my collaborative research proposal?
The process for submitting a research proposal can be initiated by contacting the PEGS Executive Leadership Committee (ELC) member whose expertise most closely aligns with your proposed field of research.

What funding opportunities are available for research collaborators?
The Funding Considerations section in the PEGS Scientific Collaboration Guidelines (106KB) provides information on the funding available for collaborative research using PEGS data.

How do I inquire about the status of a submitted research concept proposal?
You will be contacted by a member of the PEGS ELC within 90 days of the submission of your research concept proposal. Please allow 90 days from the date of submission for the review of your proposal. If you have not received a response past this period, please reach out to us with a detailed email.

Who do I contact about issues with submission, modification, or approval of a research concept proposal?
Please reach out to the PEGS ELC.

How can I conduct an add-on study and recontact participants for additional data?
It is possible to recall participants to complete additional questionnaires and/or provide data or biological samples. This involves several considerations and requirements as noted in the Data Access and Propriety section in the PEGS Scientific Collaboration Guidelines (106KB). Any research concept proposals requesting an add-on study must provide sufficient details addressing the listed requirements and justify the need for participant callback and additional data collection. Collaborators may be required to provide funding or reimburse NIEHS/PEGS for costs incurred from recontacting participants and collecting additional data.

How can I make changes to my submitted proposal?
Changes can be made to a submitted research concept proposal by contacting the assigned PEGS co-investigator and submitting a brief report describing any substantial modifications or expansions to the original proposal (e.g., the research concept, hypotheses, additional data requests). The PEGS co-investigator will review the proposed changes and present them to the PEGS ELC for review as needed. For substantial changes, it may be necessary to resubmit the Research Concept Proposal, which will be reviewed and approved by the PEGS ELC.

Can researchers submit multiple research proposals?
Yes, researchers may submit multiple research proposals if each study is distinct in terms of the science, investigators and timeline. The PEGS ELC will review each research concept proposal on its own merit. Researchers are encouraged to collate related studies into a single research concept proposal, with multiple aims as needed, to streamline the review and approval process.

Can I extend the data access period for my research?
Yes, the data access period can be extended. Please refer to the Data Access and Propriety section in the PEGS Scientific Collaboration Guidelines (106KB).

Can I store and continue to use the PEGS data after completing the analyses described in a research concept proposal?
No, researchers cannot keep or use any PEGS data or samples after the end of the approved data access period or for any other purposes not outlined in the approved research concept proposal. Upon completion of the proposed research and publication of any manuscripts, collaborators must return newly created and/or additional collected data along with appropriate documentation to NIEHS. Collaborators must destroy all local copies of PEGS data in their possession after NIEHS/PEGS acknowledges receipt of the files. Please refer to the Data Access and Propriety section in the PEGS Scientific Collaboration Guidelines (106KB) for details.

What is the authorship policy for manuscript publications?
All research is collaborative and must involve at least one PEGS investigator who will serve as co-author on manuscripts resulting from an approved Research Concept Proposal. Please refer to the Reporting section in the PEGS Scientific Collaboration Guidelines (106KB) for details.

How do I cite or acknowledge the PEGS data and cohort?
When citing or acknowledging the PEGS data and cohort, please specify the PEGS Data Freeze version used in the analyses or manuscript. Example acknowledgment: "The Personalized Environment and Genes Study was sponsored by the National Institute of Environmental Health Sciences (NIEHS), which is part of the National Institutes of Health (NIH). The PEGS data used for the analyses described in this manuscript were obtained from PEGS Data Freeze version xx.x created on mm/dd/yyyy."