Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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How would you like the opportunity to train with scientists from the world’s most prestigious toxicology program?

The NIEHS Division of the Translational Toxicology (DTT) in Research Triangle Park, North Carolina, offers postdoctoral training fellowships that prepare scientists for careers in pharmaceutical and chemical industries, regulatory agencies, and academia. DTT scientists work in multidisciplinary teams that use traditional and cutting-edge approaches to better understand how environmental factors may affect our health.

Some fellowships support work by the National Toxicology Program (NTP), which is the nation’s premier federal program for testing and evaluating environmental agents of public health concern. NTP is headquartered at NIEHS.

  • Eligibility
    Applicants must hold a Ph.D. or equivalent in toxicology or an allied science, M.D., D.V.M., or other equivalent professional degree.
    Visa assistance is available for qualified international applicants.

  • Stipend and Benefits
    The postdoctoral training program funds fellowships for up to five years. Stipends are determined by the amount of previous postdoctoral experience. Medical insurance is provided.

  • To Apply
    The number of NTP fellowships is very limited and competitive. There is no specific deadline for applying.

To check availability of a fellowship in the field of your choice, send a cover letter, curriculum vitae, and the names and contact information of three persons as references to:

Diane L. Spencer, M.S.
Diane L. Spencer, M.S.
Fellows Coordinator
Tel 984-287-3190
Fax 301-451-5718
[email protected]
P.O. Box 12233
Mail Drop K2-14
Durham, NC 27709

Applied Toxicology and Carcinogenesis

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These are non-laboratory based research fellowships in the Systems Toxicology Branch. The trainees would actively participate in the design, conduct, and evaluation of studies on diverse classes of chemicals and have extensive interaction with staff from scientific disciplines such as chemistry, pathology, toxicokinetics, toxicogenomics, genetics, epidemiology, statistics, and molecular biology.

Trainees may choose in-depth study in one subspecialty area of particular interest, and it is envisioned that trainees would author reports in the NTP Technical Report series and manuscripts for peer-reviewed publications.

Trainees will learn to perform all aspects of contracted toxicology studies for carcinogenic or non-carcinogenic endpoints (e.g., reproductive and developmental effects, immune system function).

They will also learn about NTP efforts in molecular toxicology and high throughput screening. They will receive training applicable to regulatory or industrial toxicology.

Biomolecular Screening and Computational Toxicology

These fellowships are housed in the Predictive Toxicology Branch and structured to train individuals in:

  • Developing research and testing activities in medium- and high-throughput/content screening assays for the rapid detection of biological activities of significance to toxicology
  • Developing and conducting automated screening assays with Caenorhabditis elegans that inform on biological activities of significance to toxicology
  • Developing assays and approaches to understand the genetic and epigenetic bases for differences in susceptibility
  • Developing computational tools and approaches to allow for an integrated assessment of data generated using these screening approaches with findings from traditional toxicology models and human studies

Chemistry, Chemical Metabolism, Disposition, and Toxicokinetics

These fellowships are housed in the Office of Program Operations and provide opportunities for trainees to develop expertise in the field of xenobiotic metabolism, disposition, and toxicokinetics. Trainees will be part of multidisciplinary teams and will be:

  • Participating in the design of NTP chemical disposition, metabolism, and toxicokinetic studies
  • Monitoring the conduct of studies at NTP contract laboratories
  • Evaluating and interpreting chemistry, toxicokinetics, metabolism, and disposition data
  • Presenting data at NTP and national forums
  • Preparing the data to be published in peer-reviewed literature and NTP Technical Reports series, as well as other documents

Applicants with a Ph.D. in chemistry, toxicology, pharmacology, or allied fields, with prior experience in xenobiotic metabolism and disposition, are eligible.

Health Assessment and Translation

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These fellowships are designed to provide trainees experience in the assessment, integration, interpretation, and communication of scientific information on environmental agents. The fellowship will be within the Office of the Scientific Director. Trainees will gain experience in:

  • Conducting in-depth, systematic evaluations of laboratory and clinical data, integrating relevant information for reaching conclusions, and managing peer review
  • Carrying out workshops or state of the science evaluations to address important environmental health issues
  • Interpreting and communicating toxicology information useful for public health policy

Laboratory Animal Medicine

The fellowship in Laboratory Animal Medicine is within the Comparative & Molecular Pathogenesis Branch and is designed for individuals to participate in NTP and NIEHS laboratory animal veterinary care. This includes clinical and surgical responsibilities, animal care facility management, participation in research projects, and laboratory animal pathology.

The trainee will participate in didactic training and hold clinical duty at nearby academic institutions.

The trainee will also be responsible for conducting and publishing research as first author a peer-reviewed journal.

These experiences will lead to preparation for the American College of Laboratory Animal Medicine (ACLAM) board exam. The program offers laboratory animal medicine expertise among board certified ACLAM veterinarians located in Research Triangle Park (RTP), NC.

Trainees will have opportunities to attend outside training activities and scientific meetings, as well as engaging collaborative research with scientists at NIEHS.

Systems and Mechanistic Toxicology

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The Mechanistic Toxicology Branch offers a wide range of training opportunities, which focuses on helping to develop advanced approaches to collect/interpret data generated from in vivo and in vitro experiments.

Trainees could potentially be provided with:

  • Opportunities to learn RNA, DNA and protein assessment techniques
  • Advanced training in cell culture and co-culturing techniques
  • Immunohistochemical and immunofluorescence staining techniques for detection of nuclear, cytoplasmic and membrane cell signaling proteins in rodent and human tissues
  • Training in light and confocal microscopy, ScanScope digital image acquisition, and basic toxicologic and molecular pathology.
  • Training in inorganic toxicology, stem cells methods and research, and chemical carcinogenesis research, as well as endocrine and neurotoxicology techniques.

Toxicological Pathology

The fellowship in Toxicological Pathology is within the Comparative & Molecular Pathogenesis Branch and is designed for individuals to participate in NTP and NIEHS research projects, work to achieve accuracy of NTP pathology data, learn rodent pathology, and continue education toward achievement of board certification by the American College of Veterinary Pathologists (ACVP) (Clinical or Anatomic Pathology).

Two years of veterinary pathology residency training is required.

The research performed can be thesis work toward the achievement of a Ph.D. degree by arrangement with various universities. With a world-renowned reputation for practicing toxicological pathology, the program offers rodent pathology expertise in multiple areas including cardiac, pulmonary, renal, reproductive, and immune system toxicology.

Fellows will work with NTP study pathologists to gain experience in rodent toxicology studies.

The training program features access to experienced and ACVP-certified staff members, outstanding training resources for the ACVP exam, and an excellent ACVP exam pass rate.

There are opportunities to attend outside training activities and scientific meetings, as well as engaging in collaborative research with intramural NTP and NIEHS scientists.