Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics -
Tel 984-287-3108
Fax 919-541-3647
[email protected]Curriculum Vitae (344KB)
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P.O. Box 12233Mail Drop K2-17Durham, NC 27709
Research Summary
The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch and across the National Toxicology Program.
Specific projects include:
- Development of toxicogenomic models that predict apical toxicological outcomes
- Evaluation of methods for scaling toxicogenomic technologies
- In vitro / In vivo extrapolation
- Analytics pipeline development for Tox21 high throughput screening data
- Development of network-based inference approaches for biological read-across using Tox21 data
- Development of software for genomic benchmark dose analysis
Scientists & Staff
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics -
Tel 984-287-3108
Fax 919-541-3647
[email protected]Curriculum Vitae (344KB)
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Frank G. Chao, Ph.D.
Computational Biologist -
Tel 984-287-4066
Fax 919-541-3647
[email protected]
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Jui-Hua Hsieh, Ph.D.
Staff Scientist -
Tel 984-287-3142
[email protected]
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Fred Parham, Ph.D.
Mathematical Statistician -
Tel 984-287-3169
[email protected]Curriculum Vitae (202KB)
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Trey O. Saddler
Contractor - Data Scientist -
Tel 984-287-3180
[email protected]
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Zicong Wang
Contractor - Software Developer -
Tel 984-287-4494
[email protected]
Recent Publications
Software
- Tox21 Toolbox
The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.