Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
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Tel 984-287-3108
Fax 919-541-3647
[email protected]
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530 DAVIS DR (RTP)
530 Davis Drive (Keystone Bldg)
Durham, NC 27713
Research Summary
The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch and across the National Toxicology Program.
Specific projects include:
- Development of toxicogenomic models that predict apical toxicological outcomes
- Evaluation of methods for scaling toxicogenomic technologies
- In vitro / In vivo extrapolation
- Analytics pipeline development for Tox21 high throughput screening data
- Development of network-based inference approaches for biological read-across using Tox21 data
- Development of software for genomic benchmark dose analysis
Scientists & Staff
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
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Tel 984-287-3108
Fax 919-541-3647
[email protected]
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Frank G. Chao, Ph.D.
Computational Biologist
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Tel 984-287-4066
Fax 919-541-3647
[email protected]
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Jui-Hua Hsieh, Ph.D.
Staff Scientist
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Tel 984-287-3142
[email protected]
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Frederick M. Parham, Ph.D.
Mathematical Statistician
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Tel 984-287-3169
[email protected]
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Trey O. Saddler
Contractor - Data Scientist
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Tel 984-287-3180
[email protected]
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Zicong Wang
Contractor - Software Developer
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Tel 984-287-4494
[email protected]
Recent Publications
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Fecho K, Tucker N, Beasley J, Auerbach S, Bizon C, Tropsha A. Elucidating the mechanistic relationships between peroxisome proliferator-activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph.
Frontiers in toxicology.
2025;7:1549268.
[
AbstractFecho K, Tucker N, Beasley J, Auerbach S, Bizon C, Tropsha A. Elucidating the mechanistic relationships between peroxisome proliferator-activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph. Frontiers in toxicology. 2025
]
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Celardo I, Aschner M, Ashton R, Carstens K, Cediel-Ulloa A, Cöllen E, Crofton K, Debad S, Dreser N, Fitzpatrick S, Fritsche E, Gutsfeld S, Hardy B, Hartung T, Hessel E, Heusinkveld H, Hogberg H, Hsieh J, Kanda Y, Knight G, Knudsen T, Koch K, Kuchovska E, Mangas I, Marty M, Melching-Kollmuss S, Müller I, Müller P, Myhre O, Paparella M, Pitzer E, Bal-Price A, Sachana M, Schlüppmann K, Shafer T, Schäfer J, Smirnova L, Tal T, Tanaskov Y, Tangianu S, Testa G, Ückert A, Whelan M, Leist M. Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing.
ALTEX.
2025;42(2):323-349.
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AbstractCelardo I, Aschner M, Ashton R, Carstens K, Cediel-Ulloa A, Cöllen E, Crofton K, Debad S, Dreser N, Fitzpatrick S, Fritsche E, Gutsfeld S, Hardy B, Hartung T, Hessel E, Heusinkveld H, Hogberg H, Hsieh J, Kanda Y, Knight G, Knudsen T, Koch K, Kuchovska E, Mangas I, Marty M, Melching-Kollmuss S, Müller I, Müller P, Myhre O, Paparella M, Pitzer E, Bal-Price A, Sachana M, Schlüppmann K, Shafer T, Schäfer J, Smirnova L, Tal T, Tanaskov Y, Tangianu S, Testa G, Ückert A, Whelan M, Leist M. Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing. ALTEX. 2025
]
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Tandon A, Howard B, Green A, Elmore R, Shah R, Merrick A, Shockley K, Ryan K, Hsieh J. Artificial intelligence (AI)-driven morphological assessment of zebrafish larvae for developmental toxicity chemical screening.
Aquatic toxicology (Amsterdam, Netherlands).
2025 Aug;285:107415.
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AbstractTandon A, Howard B, Green A, Elmore R, Shah R, Merrick A, Shockley K, Ryan K, Hsieh J. Artificial intelligence (AI)-driven morphological assessment of zebrafish larvae for developmental toxicity chemical screening. Aquatic toxicology (Amsterdam, Netherlands). 2025 Aug
]
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Lin T, Hsu K, Chou C, Tsai E, Wu Y, Sung T, Hsu J, Hsieh J, Yen S, Chang Y, Pan S, Huang W, Yang C. Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis.
Biochemical pharmacology.
2025 Jul;237:116959.
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AbstractLin T, Hsu K, Chou C, Tsai E, Wu Y, Sung T, Hsu J, Hsieh J, Yen S, Chang Y, Pan S, Huang W, Yang C. Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis. Biochemical pharmacology. 2025 Jul
]
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Corton J, Gift J, Auerbach S, Liu J, Das K, Ren H, Lang J, Chernoff N, Lau C, Hill D. Dose-response modeling of effects in mice after exposure to a polyfluoroalkyl substance (Nafion byproduct 2).
Toxicological sciences : an official journal of the Society of Toxicology.
2025 Jun 01;205(2):380-400.
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AbstractCorton J, Gift J, Auerbach S, Liu J, Das K, Ren H, Lang J, Chernoff N, Lau C, Hill D. Dose-response modeling of effects in mice after exposure to a polyfluoroalkyl substance (Nafion byproduct 2). Toxicological sciences : an official journal of the Society of Toxicology. 2025 Jun 01
]
More Recent Publications from PubMed
Software
- Tox21 Toolbox
The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.
