Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Predictive Toxicology Branch
Leader, Toxicoinformatics
Research Summary
The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch and across the National Toxicology Program.
Specific projects include:
- Development of toxicogenomic models that predict apical toxicological outcomes
- Evaluation of methods for scaling toxicogenomic technologies
- In vitro / In vivo extrapolation
- Analytics pipeline development for Tox21 high throughput screening data
- Development of network-based inference approaches for biological read-across using Tox21 data
- Development of software for genomic benchmark dose analysis
Scientists & Staff
Leader, Toxicoinformatics
Mathematical Statistician
Zicong Wang
Contractor - Software Developer
Recent Publications
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Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.
Chemical research in toxicology.
2026 Apr 20;39(4):624-635.
[
AbstractNgan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study. Chemical research in toxicology. 2026 Apr 20
]
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Auerbach S, Cora M, Liu Y, Luh J, Prince L, Roberts G, Shipkowski K, Waidyanatha S. NIEHS Report on the In Vivo Repeat Dose Biological Potency Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in Female Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6D2F1/Crl Mice (Whole-body Inhalation Studies): NIEHS Report 13
NIEHS Report Series.
2026 Apr [Epub ahead of print].
[
AbstractAuerbach S, Cora M, Liu Y, Luh J, Prince L, Roberts G, Shipkowski K, Waidyanatha S. NIEHS Report on the In Vivo Repeat Dose Biological Potency Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in Female Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6D2F1/Crl Mice (Whole-body Inhalation Studies): NIEHS Report 13 NIEHS Report Series. 2026 Apr
]
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Auerbach S, Cora M, Liu Y, Luh J, Prince L, Roberts G, Shipkowski K, Waidyanatha S. NIEHS Report on the In Vivo Repeat Dose Biological Potency Studies of 1,2-Dichlorobenzene (CASRN 95-50-1) in Female Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6D2F1/Crl Mice (Whole-body Inhalation Studies): NIEHS Report 12
NIEHS Report Series.
2026 Apr [Epub ahead of print].
[
AbstractAuerbach S, Cora M, Liu Y, Luh J, Prince L, Roberts G, Shipkowski K, Waidyanatha S. NIEHS Report on the In Vivo Repeat Dose Biological Potency Studies of 1,2-Dichlorobenzene (CASRN 95-50-1) in Female Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6D2F1/Crl Mice (Whole-body Inhalation Studies): NIEHS Report 12 NIEHS Report Series. 2026 Apr
]
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Bommarito P, Taylor K, Rooney A, Addo K, Auerbach S, Blain R, Ferguson K, Gaston S, Hall S, Jackson C, Lemeris C, Silva R, Tracy W, Walker V, Howdeshell K. Systematic evidence map on the association between exposure to personal care products and fetal growth.
Environment international.
2026 Mar;209:110147.
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AbstractBommarito P, Taylor K, Rooney A, Addo K, Auerbach S, Blain R, Ferguson K, Gaston S, Hall S, Jackson C, Lemeris C, Silva R, Tracy W, Walker V, Howdeshell K. Systematic evidence map on the association between exposure to personal care products and fetal growth. Environment international. 2026 Mar
]
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Cong G, Patton R, Chao F, Svoboda D, Erickson J, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S. Transplatformer: translating toxicogenomic profiles between generations of platforms.
BMC bioinformatics.
2026 Jan 30;27(1):.
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AbstractCong G, Patton R, Chao F, Svoboda D, Erickson J, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S. Transplatformer: translating toxicogenomic profiles between generations of platforms. BMC bioinformatics. 2026 Jan 30
]
Software
- Tox21 Toolbox
The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.
