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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

Scott S. Auerbach, Ph.D.
Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
Tel 984-287-3108
Fax 919-541-3647
[email protected]
P.O. Box 12233
Mail Drop K2-17
Durham, NC 27709
Toxicoinformatics Group - Biomolecular Screening Branch

Research Summary

The Toxicoinformatics Group leads the development of data analytic approaches related to Tox21 data and provides informatics support for a variety of projects within the Biomolecular Screening Branch  and across the National Toxicology Program.

Specific projects include:

  • Development of toxicogenomic models that predict apical toxicological outcomes
  • Evaluation of methods for scaling toxicogenomic technologies
  • In vitro / In vivo extrapolation
  • Analytics pipeline development for Tox21 high throughput screening data
  • Development of network-based inference  approaches for biological read-across using Tox21 data
  • Development of software for genomic benchmark dose analysis

Scientists & Staff

Scott S. Auerbach, Ph.D.
Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics
Tel 984-287-3108
Fax 919-541-3647
[email protected]
Frank G. Chao, Ph.D.
Frank G. Chao, Ph.D.
Computational Biologist
Tel 984-287-4066
Fax 919-541-3647
[email protected]
Jui-Hua Hsieh, Ph.D.
Jui-Hua Hsieh, Ph.D.
Staff Scientist
Tel 984-287-3142
[email protected]
Fred Parham, Ph.D.
Fred Parham, Ph.D.
Mathematical Statistician
Tel 984-287-3169
[email protected]
Trey O. Saddler
Trey O. Saddler
Contractor - Data Scientist
Tel 984-287-3180
[email protected]
Zicong Wang
Zicong Wang
Contractor - Software Developer
Tel 984-287-4494
[email protected]

Recent Publications

    Software

    • Tox21 Toolbox
      The Tox21 toolbox contains useful tools for accessing and visualizing the Tox21 quantitative high throughput screening (qHTS) 10K library data, as well as integrating with other publicly available data.