Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Helena Hogberg, Ph.D., joined the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) within the division of translational toxicology (DTT) as a Staff Scientist in the end of 2021. She is conducting research drawing on her broad expertise in applying in vitro methods to assessing developmental neurotoxicity (DNT) potential of chemicals. Moreover, she is leading and contributing to validation efforts both in US and Europe.
She is or has been serving on a number of governmental entities, expert groups and scientific advisory boards including OECD, U.S. EPA, EFSA, Michael J Fox Foundation, and European Commission-funded projects.
Prior to joining DTT, she was the Deputy Director of the Center for Alternatives to Animal Testing (CAAT) within the Johns Hopkins University Bloomberg School for Public Health. She received her Ph.D. her in toxicology from Stockholm University but performed her research at the European Centre for the Validation of Alternative Methods (ECVAM) in Ispra, Italy.
Recent Publications
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Sachana M, Hogberg H, Mangas I. From concept to regulation: OECD's role in the development of the DNT in vitro battery.
Frontiers in toxicology.
2026;8:1774469.
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AbstractSachana M, Hogberg H, Mangas I. From concept to regulation: OECD's role in the development of the DNT in vitro battery. Frontiers in toxicology. 2026
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Karmaus A, Kreutz A, Oyetade O, Friedman K, Paparella M, Reinke E, Allen D, Hogberg H, Kleinstreuer N. Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology.
Frontiers in toxicology.
2026;8:1778353.
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AbstractKarmaus A, Kreutz A, Oyetade O, Friedman K, Paparella M, Reinke E, Allen D, Hogberg H, Kleinstreuer N. Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology. Frontiers in toxicology. 2026
]
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Deisenroth C, Foley B, Rogers E, Kühnlenz J, Chen W, Feshuk M, Bianchi E, McKenna J, Hill B, Larocca J, LeCluyse E, Kleinstreuer N, Thomas R, Hogberg H. Interlaboratory validation of the human thyroid microtissue assay.
Toxicological sciences : an official journal of the Society of Toxicology.
2026 Feb 18;209(2):.
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AbstractDeisenroth C, Foley B, Rogers E, Kühnlenz J, Chen W, Feshuk M, Bianchi E, McKenna J, Hill B, Larocca J, LeCluyse E, Kleinstreuer N, Thomas R, Hogberg H. Interlaboratory validation of the human thyroid microtissue assay. Toxicological sciences : an official journal of the Society of Toxicology. 2026 Feb 18
]
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Kreutz A, Chang X, Lawless M, Proença S, Schaller S, Kleinstreuer N, Hogberg H. Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation.
Toxicological sciences : an official journal of the Society of Toxicology.
2026 Feb 18;209(2):.
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AbstractKreutz A, Chang X, Lawless M, Proença S, Schaller S, Kleinstreuer N, Hogberg H. Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation. Toxicological sciences : an official journal of the Society of Toxicology. 2026 Feb 18
]
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Roberts R, Behl M, Hogberg H, Dunayevich E, Morton M, Rockley K, Walker A, Pierson J. Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment.
Drug discovery today.
2026 Jan;31(1):104569.
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AbstractRoberts R, Behl M, Hogberg H, Dunayevich E, Morton M, Rockley K, Walker A, Pierson J. Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment. Drug discovery today. 2026 Jan
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