Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Chief, Comparative and Molecular Pathogenesis Branch
The primary focus of the NIEHS Mouse Embryo Phenotyping Core is to provide expertise and support for the evaluation of pathology phenotypes of genetically altered mice. Efforts include evaluation of the causes of embryonic lethal phenotypes. Assistance is provided with the collection, histologic processing and pathological assessment of embryos.
Recent Publications
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Jackson T, Alewel D, Vance S, Gavett S, Schladweiler M, Evansky P, Monsees M, Freeborn D, Martin J, George I, Warren N, Grindstaff R, Kodavanti P, Crabbs T, Fisher R, Brown Q, Ganta C, Sills R, Herbert R, Kodavanti U. Respiratory health outcomes following co-exposure to subchronic high temperature, episodic wildfire smoke exposure, and high-cholesterol diet.
Inhalation toxicology.
2026 Sep;38(8):433-454.
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AbstractJackson T, Alewel D, Vance S, Gavett S, Schladweiler M, Evansky P, Monsees M, Freeborn D, Martin J, George I, Warren N, Grindstaff R, Kodavanti P, Crabbs T, Fisher R, Brown Q, Ganta C, Sills R, Herbert R, Kodavanti U. Respiratory health outcomes following co-exposure to subchronic high temperature, episodic wildfire smoke exposure, and high-cholesterol diet. Inhalation toxicology. 2026 Sep
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Hall L, Hsieh J, Marvel S, Behl M, Fritsche E, Koch K, Kreutz A, Leist M, Muriana A, Shafer T, Stanko J, Sills R, Hogberg H, McPherson C. Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment.
Neurotoxicology.
2026 Jul;115:103485.
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AbstractHall L, Hsieh J, Marvel S, Behl M, Fritsche E, Koch K, Kreutz A, Leist M, Muriana A, Shafer T, Stanko J, Sills R, Hogberg H, McPherson C. Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment. Neurotoxicology. 2026 Jul
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Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion.
Cell reports.
2025 Jul 22;44(7):115978.
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AbstractXu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 22
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Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.
PloS one.
2024;19(1):e0296699.
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AbstractBrooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024
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Panzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11
NIEHS Report Series.
2024 Oct [Epub ahead of print].
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AbstractPanzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11 NIEHS Report Series. 2024 Oct
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