Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Research Summary
The Epigenetics and RNA Biology Laboratory investigates fundamental mechanisms by which epigenetics — non-genetic modulation and alterations — influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches.
In addition to the cutting edge hypothesis driven research of its investigators the laboratory provides leadership and support to the NIEHS in areas of genomics, epigenomics, mass spectrometry, and bioinformatics analyses. These endeavors build and research strengths established in the prior Laboratory of Molecular Carcinogenesis and extend the scope of the research beyond cancer to examine a broad range of environmental impacts on human health and development.
Principal Investigators
Chromatin & Gene Expression
Deputy Director, NIEHS;
NIH Distinguished Investigator
Eukaryotic Transcriptional Regulation
Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Macromolecular Structure
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Transcriptional Responses in Disease
Scientific Support Staff
Don Cox
Administrative Specialist
Derrick L. Raynor
Administrative Technician
Publications
Recent Publications
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Cummings M, Liu B, Paudel S, Wang X, Sgouridis S, Peng X, Hu G, Wang X. Uterine function and reproduction aging. I. Molecular and structural alterations associated with impaired decidualization in aged mouse uteri.
Uterine research.
2026;1(1):7.
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AbstractCummings M, Liu B, Paudel S, Wang X, Sgouridis S, Peng X, Hu G, Wang X. Uterine function and reproduction aging. I. Molecular and structural alterations associated with impaired decidualization in aged mouse uteri. Uterine research. 2026
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Chapus F, Day C, Kammel L, Yasar P, Bennett B, Scappini E, Tucker C, Sifre M, Bregio C, Rodriguez J. Differential chromatin enrichment of histone H3K27me3 underlies variable cell responses to estrogen and endocrine treatment.
The Journal of biological chemistry.
2026 Nov 04 [Epub ahead of print].
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AbstractChapus F, Day C, Kammel L, Yasar P, Bennett B, Scappini E, Tucker C, Sifre M, Bregio C, Rodriguez J. Differential chromatin enrichment of histone H3K27me3 underlies variable cell responses to estrogen and endocrine treatment. The Journal of biological chemistry. 2026 Nov 04
]
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Hirose K, Chen X, Kalyanaraman C, Waddingham M, Nakamura M, Zhang F, Chen C, Yao S, Chang S, Yu H, Wang J, Barca E, Nakano H, Hsu A, Khyeam S, Gonzalez Ortega S, Tajima K, Yoneshiro T, Zhang H, Padmanabhan A, Kajimura S, Haldar S, Nakano A, Murai M, Fujihara Y, Otsu K, Quinzii C, Jacobson M, Hu G, Pearson J, Huang G. A muscle-enriched mitochondrial protein regulates postnatal heart growth through mitonuclear ubiquinone-PPAR signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2026 Oct 20;123(42):e2619615123.
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AbstractHirose K, Chen X, Kalyanaraman C, Waddingham M, Nakamura M, Zhang F, Chen C, Yao S, Chang S, Yu H, Wang J, Barca E, Nakano H, Hsu A, Khyeam S, Gonzalez Ortega S, Tajima K, Yoneshiro T, Zhang H, Padmanabhan A, Kajimura S, Haldar S, Nakano A, Murai M, Fujihara Y, Otsu K, Quinzii C, Jacobson M, Hu G, Pearson J, Huang G. A muscle-enriched mitochondrial protein regulates postnatal heart growth through mitonuclear ubiquinone-PPAR signaling. Proceedings of the National Academy of Sciences of the United States of America. 2026 Oct 20
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Liu Y, Chrysovergis K, Johnson K, Williams J, Lih F, Deterding L, Wade P. Short-term methionine starvation reshapes diurnal hepatic m6A RNA methylation.
The Journal of biological chemistry.
2026 Oct 15;302(12):113645.
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AbstractLiu Y, Chrysovergis K, Johnson K, Williams J, Lih F, Deterding L, Wade P. Short-term methionine starvation reshapes diurnal hepatic m6A RNA methylation. The Journal of biological chemistry. 2026 Oct 15
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Pathania R, Papas B, Kosak J, Cinghu S, Kumar D, Deskin B, Oldfield A, Pandey A, Siladi A, Tiwari S, Iannone M, Sifre M, Bortner C, Xu X, Mahalingam R, Deep G, Shinde R, Kotla S, Lakshmanan I, Ponnusamy M, Fessler M, Hu G, Thangaraju M, Yang P, Jothi R. Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer.
bioRxiv : the preprint server for biology.
2026 Aug 26 [Epub ahead of print].
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AbstractPathania R, Papas B, Kosak J, Cinghu S, Kumar D, Deskin B, Oldfield A, Pandey A, Siladi A, Tiwari S, Iannone M, Sifre M, Bortner C, Xu X, Mahalingam R, Deep G, Shinde R, Kotla S, Lakshmanan I, Ponnusamy M, Fessler M, Hu G, Thangaraju M, Yang P, Jothi R. Malignant epithelial diversification and inflammatory neutrophil remodeling define a transitional stage between tumor cell dissemination and overt metastatic outgrowth in breast cancer. bioRxiv : the preprint server for biology. 2026 Aug 26
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More Recent Publications from PubMed
