Systems Toxicology Branch
William Gwinn, Ph.D. is an inhalation toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. He serves as a study scientist for chemicals selected for toxicity and carcinogenicity evaluation by the NTP. His expertise is in respiratory toxicology, immunology, and inflammation, and he serves primarily as a project lead for inhalation studies within the DTT including the application of in vitro lung models to inhalation toxicology.
Gwinn received a B.S. in Biology from The College of William and Mary, Williamsburg, VA in 1997, a M.S. in Pathology from Duke University, Durham, NC in 2001, and a Ph.D. in Immunology from The George Washington University School of Medicine and Health Sciences, Washington, DC in 2006. He completed postdoctoral training at Duke University and within the DIR and DNTP at NIEHS.
Recent Publications
- Le Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays. Archives of toxicology. 2026 Mar 05 [Epub ahead of print]. [ AbstractLe Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays. Archives of toxicology. 2026 Mar 05 ]
- Cao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives. In vitro cellular & developmental biology. Animal. 2021 Feb;57(2):104-132. [ AbstractCao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives. In vitro cellular & developmental biology. Animal. 2021 Feb ]
- Gwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicological sciences : an official journal of the Society of Toxicology. 2020 Aug 01;176(2):343-354. [ AbstractGwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicological sciences : an official journal of the Society of Toxicology. 2020 Aug 01 ]
- Morgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10 NTP Research Reports. 2019 Aug [Epub ahead of print]. [ AbstractMorgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10 NTP Research Reports. 2019 Aug ]
- Gwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7 NTP Research Reports. 2018 Dec [Epub ahead of print]. [ AbstractGwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7 NTP Research Reports. 2018 Dec ]