
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Toxicoinformatics Group
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Scott S. Auerbach, Ph.D.
Leader, Toxicoinformatics -
Tel 984-287-3108
Fax 919-541-3647
[email protected] -
530 DAVIS DR (RTP)530 Davis Drive (Keystone Bldg)Durham, NC 27713

Scott S. Auerbach, Ph.D., DABT is a Molecular Toxicologist that leads the Toxicoinformatics Group within the Predictive Toxicology Branch of the Division of Translational Toxicology at NIEHS. In additional to his role as Toxicoinformatics Group Leader, he leads efforts related to the analysis and interpretation of multivariate data sets (i.e., microarray, RNA-seq, High-throughput screening) for purposes of informing toxicological assessment.
His specific responsibilities include:
- Oversight of the NTP DrugMatrix resource and genomic dose-response analysis tools, BMDExpress 2 and BMDExpress 3
- Multivariate data analysis and modeling with the purpose of prioritizing chemicals for targeted toxicological assessment
- Use of machine learning approaches to develop multivariate data models that diagnosis and predict toxicological pathology and disease
- Application of short-term in vivo transcriptomic studies to allow for the identification of genomic benchmark dose values and mechanistic characterization
- Pathway and network level characterization of toxicity related omics results with the goal of understanding mechanisms of target organ toxicity
- Use of literature mining and data driven bioinformatics approaches to understand the relationship between chemogenomic perturbations and disease
- High dimensional data analysis and visualization via network topology
- Auerbach also helped lead the NTP team's toxicology efforts related to the West Virginia chemical spill that occurred in 2014
- Leadership of a research group that has developed numerous tools and resources for analyzing and accessing predictive toxicology data
Auerbach received a B.S. in biochemistry and molecular biology from the Pennsylvania State University, State College, Pennsylvania and a Ph.D. in pharmacology from the University of Washington, Seattle, Washington.
Recent Publications
- Fecho K, Tucker N, Beasley J, Auerbach S, Bizon C, Tropsha A. Elucidating the mechanistic relationships between peroxisome proliferator-activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph. Frontiers in toxicology. 2025;7:1549268. [ AbstractFecho K, Tucker N, Beasley J, Auerbach S, Bizon C, Tropsha A. Elucidating the mechanistic relationships between peroxisome proliferator-activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph. Frontiers in toxicology. 2025 ]
- Corton J, Gift J, Auerbach S, Liu J, Das K, Ren H, Lang J, Chernoff N, Lau C, Hill D. Dose-response modeling of effects in mice after exposure to a polyfluoroalkyl substance (Nafion byproduct 2). Toxicological sciences : an official journal of the Society of Toxicology. 2025 Jun 01;205(2):380-400. [ AbstractCorton J, Gift J, Auerbach S, Liu J, Das K, Ren H, Lang J, Chernoff N, Lau C, Hill D. Dose-response modeling of effects in mice after exposure to a polyfluoroalkyl substance (Nafion byproduct 2). Toxicological sciences : an official journal of the Society of Toxicology. 2025 Jun 01 ]
- Pannala V, Hari A, AbdulHameed M, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S, Wallqvist A. Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model. Toxicological sciences : an official journal of the Society of Toxicology. 2025 Apr 01;204(2):154-168. [ AbstractPannala V, Hari A, AbdulHameed M, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S, Wallqvist A. Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model. Toxicological sciences : an official journal of the Society of Toxicology. 2025 Apr 01 ]
- Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar;66(3):99-121. [ AbstractCarberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar ]
- Corton J, Auerbach S, Koyama N, Mezencev R, Yauk C, Suzuki T. Review and meta-analysis of gene expression biomarkers predictive of chemical-induced genotoxicity in vivo. Environmental and molecular mutagenesis. 2025 Jan 21 [Epub ahead of print]. [ AbstractCorton J, Auerbach S, Koyama N, Mezencev R, Yauk C, Suzuki T. Review and meta-analysis of gene expression biomarkers predictive of chemical-induced genotoxicity in vivo. Environmental and molecular mutagenesis. 2025 Jan 21 ]
NTP Reports
- National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun ]
- National Toxicology Program. NTP Immunotoxicity Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice: Immunotoxicity Report 01 NTP Immunotoxicity Reports. 2020 Jul [Epub ahead of print]. [ AbstractNational Toxicology Program. NTP Immunotoxicity Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice: Immunotoxicity Report 01 NTP Immunotoxicity Reports. 2020 Jul ]
- National Toxicology Program. NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): DART Report 02 NTP Developmental and Reproductive Toxicity Reports. 2020 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): DART Report 02 NTP Developmental and Reproductive Toxicity Reports. 2020 Jun ]
- National Toxicology Program. Toxicology and carcinogenesis studies of 2-hydroxy-4-methoxybenzophenone administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2020 May [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of 2-hydroxy-4-methoxybenzophenone administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2020 May ]
- National Toxicology Program. NTP Research Report on In Vivo Repeat Dose Biological Potency Study of Triphenyl Phosphate (CAS No. 115-86-6) in Male Sprague Dawley Rats (Hsd: Sprague Dawley SD) (Gavage Studies): Research Report 8 NTP Research Reports. 2018 Dec [Epub ahead of print]. [ AbstractNational Toxicology Program. NTP Research Report on In Vivo Repeat Dose Biological Potency Study of Triphenyl Phosphate (CAS No. 115-86-6) in Male Sprague Dawley Rats (Hsd: Sprague Dawley SD) (Gavage Studies): Research Report 8 NTP Research Reports. 2018 Dec ]