Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Toxicoinformatics Group
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Jui-Hua Hsieh, Ph.D.
Staff Scientist -
Tel 984-287-3142
[email protected] -
530 DAVIS DR (RTP)530 Davis Drive (Keystone Bldg)Durham, NC 27713
Jui-Hua Hsieh, Ph.D., is a Staff Scientist in the Predictive Toxicology Branch of the Division of Translational Toxicology (DTT). Her primary roles involve method development and applications on concentration-response data, web application development for data visualization, and model development for prioritizing and predicting potential human toxicants.
Prior to joining the DTT in 2011, she received her B.S. degree in Pharmacy from National Taiwan University and her Ph.D. degree in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. Her Ph.D. work involves the development and application of cheminformatics tools for drug discovery projects, particularly hit identification in virtual screening.
Recent Publications
- Celardo I, Aschner M, Ashton R, Carstens K, Cediel-Ulloa A, Cöllen E, Crofton K, Debad S, Dreser N, Fitzpatrick S, Fritsche E, Gutsfeld S, Hardy B, Hartung T, Hessel E, Heusinkveld H, Hogberg H, Hsieh J, Kanda Y, Knight G, Knudsen T, Koch K, Kuchovska E, Mangas I, Marty M, Melching-Kollmuss S, Müller I, Müller P, Myhre O, Paparella M, Pitzer E, Bal-Price A, Sachana M, Schlüppmann K, Shafer T, Schäfer J, Smirnova L, Tal T, Tanaskov Y, Tangianu S, Testa G, Ückert A, Whelan M, Leist M. Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing. ALTEX. 2025;42(2):323-349. [ AbstractCelardo I, Aschner M, Ashton R, Carstens K, Cediel-Ulloa A, Cöllen E, Crofton K, Debad S, Dreser N, Fitzpatrick S, Fritsche E, Gutsfeld S, Hardy B, Hartung T, Hessel E, Heusinkveld H, Hogberg H, Hsieh J, Kanda Y, Knight G, Knudsen T, Koch K, Kuchovska E, Mangas I, Marty M, Melching-Kollmuss S, Müller I, Müller P, Myhre O, Paparella M, Pitzer E, Bal-Price A, Sachana M, Schlüppmann K, Shafer T, Schäfer J, Smirnova L, Tal T, Tanaskov Y, Tangianu S, Testa G, Ückert A, Whelan M, Leist M. Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing. ALTEX. 2025 ]
- Tandon A, Howard B, Green A, Elmore R, Shah R, Merrick A, Shockley K, Ryan K, Hsieh J. Artificial intelligence (AI)-driven morphological assessment of zebrafish larvae for developmental toxicity chemical screening. Aquatic toxicology (Amsterdam, Netherlands). 2025 Aug;285:107415. [ AbstractTandon A, Howard B, Green A, Elmore R, Shah R, Merrick A, Shockley K, Ryan K, Hsieh J. Artificial intelligence (AI)-driven morphological assessment of zebrafish larvae for developmental toxicity chemical screening. Aquatic toxicology (Amsterdam, Netherlands). 2025 Aug ]
- Lin T, Hsu K, Chou C, Tsai E, Wu Y, Sung T, Hsu J, Hsieh J, Yen S, Chang Y, Pan S, Huang W, Yang C. Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis. Biochemical pharmacology. 2025 Jul;237:116959. [ AbstractLin T, Hsu K, Chou C, Tsai E, Wu Y, Sung T, Hsu J, Hsieh J, Yen S, Chang Y, Pan S, Huang W, Yang C. Identification of pyrazole scaffold inhibitors targeting cyclin-dependent kinase 8 for potential use in pulmonary fibrosis. Biochemical pharmacology. 2025 Jul ]
- Yang C, Wu Y, Tu H, Yeh Y, Lin T, Sung T, Li M, Yen S, Hsieh J, Yu M, Hsieh S, Hsieh H, Pan S, Hsu K. Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 May;12(19):e2416323. [ AbstractYang C, Wu Y, Tu H, Yeh Y, Lin T, Sung T, Li M, Yen S, Hsieh J, Yu M, Hsieh S, Hsieh H, Pan S, Hsu K. Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 May ]
- Ooka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, Hsieh J, Collins B, Dunnick J, Dixon D, Xia M. Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action. Environmental science & technology. 2025 Mar 18;59(10):4778-4787. [ AbstractOoka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, Hsieh J, Collins B, Dunnick J, Dixon D, Xia M. Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action. Environmental science & technology. 2025 Mar 18 ]
NTP Reports
- National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun ]