Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Toxicoinformatics Group
Jui-Hua Hsieh, Ph.D., is a Staff Scientist in the Predictive Toxicology Branch of the Division of Translational Toxicology (DTT). Her primary roles involve method development and applications on concentration-response data, web application development for data visualization, and model development for prioritizing and predicting potential human toxicants.
Prior to joining the DTT in 2011, she received her B.S. degree in Pharmacy from National Taiwan University and her Ph.D. degree in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. Her Ph.D. work involves the development and application of cheminformatics tools for drug discovery projects, particularly hit identification in virtual screening.
Recent Publications
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Tseng H, Wu Y, Chen Y, Lin T, Fang-Chin Y, Wu Y, Sung T, Yen S, Hsieh J, Hsu K, Pan S. Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors.
Journal of enzyme inhibition and medicinal chemistry.
2026 Dec;41(1):2600746.
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AbstractTseng H, Wu Y, Chen Y, Lin T, Fang-Chin Y, Wu Y, Sung T, Yen S, Hsieh J, Hsu K, Pan S. Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors. Journal of enzyme inhibition and medicinal chemistry. 2026 Dec
]
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Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.
Chemical research in toxicology.
2026 Apr 20;39(4):624-635.
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AbstractNgan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study. Chemical research in toxicology. 2026 Apr 20
]
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Wu Y, Yang C, Lin T, Yeh Y, Fang-Chin Y, Sung T, Yen S, Hsieh J, Chung C, Pan S, Hsu K. Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment.
Journal of chemical information and modeling.
2026 Jan 12;66(1):577-590.
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AbstractWu Y, Yang C, Lin T, Yeh Y, Fang-Chin Y, Sung T, Yen S, Hsieh J, Chung C, Pan S, Hsu K. Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment. Journal of chemical information and modeling. 2026 Jan 12
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Konrad K, Allen-Moyer K, Ellis L, Hessel E, Jaka O, Muriana A, Martínez B, Del Pozo A, Schiavone V, Di Donato V, Sanz C, Truong L, Tanguay R, Shockley K, Ryan K, Hsieh J. Power calculations for larval zebrafish in light-dark transition test for developmental neurotoxicity.
Neurotoxicology.
2026 Jan;112:103371.
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AbstractKonrad K, Allen-Moyer K, Ellis L, Hessel E, Jaka O, Muriana A, Martínez B, Del Pozo A, Schiavone V, Di Donato V, Sanz C, Truong L, Tanguay R, Shockley K, Ryan K, Hsieh J. Power calculations for larval zebrafish in light-dark transition test for developmental neurotoxicity. Neurotoxicology. 2026 Jan
]
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Yang C, Lin T, Hsieh J, Hsu K, Chiueh P. Establishment of an Integrated Model for Predicting Compound Mutagenicity with a Feature Importance Analysis.
Journal of chemical information and modeling.
2025 Nov 10;65(21):11558-11571.
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AbstractYang C, Lin T, Hsieh J, Hsu K, Chiueh P. Establishment of an Integrated Model for Predicting Compound Mutagenicity with a Feature Importance Analysis. Journal of chemical information and modeling. 2025 Nov 10
]
