Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Toxicoinformatics Group
Jui-Hua Hsieh, Ph.D., is a Staff Scientist in the Predictive Toxicology Branch of the Division of Translational Toxicology (DTT). Her primary roles involve method development and applications on concentration-response data, web application development for data visualization, and model development for prioritizing and predicting potential human toxicants.
Prior to joining the DTT in 2011, she received her B.S. degree in Pharmacy from National Taiwan University and her Ph.D. degree in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. Her Ph.D. work involves the development and application of cheminformatics tools for drug discovery projects, particularly hit identification in virtual screening.
Recent Publications
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Adesina P, Zhang L, Sukhawanit C, Wood S, Zhao J, Li Z, Sakamuru S, Ferguson S, Hsieh J, Reif D, Huang R, Xia M. Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor.
Chemical research in toxicology.
2026 Jul 14 [Epub ahead of print].
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AbstractAdesina P, Zhang L, Sukhawanit C, Wood S, Zhao J, Li Z, Sakamuru S, Ferguson S, Hsieh J, Reif D, Huang R, Xia M. Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor. Chemical research in toxicology. 2026 Jul 14
]
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Truong L, Hsieh J, Ellis L, Jaka O, Muriana A, Molina-Martínez B, Del Pozo A, Schiavone V, Di Donato V, Sanz C, Tanguay R, Hessel E, Ryan K. Zebrafish behavioral assessment as a first-tier whole-organism NAM for developmental neurotoxicity: A multi-laboratory evaluation.
Neurotoxicology.
2026 Jul 02;116:103504.
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AbstractTruong L, Hsieh J, Ellis L, Jaka O, Muriana A, Molina-Martínez B, Del Pozo A, Schiavone V, Di Donato V, Sanz C, Tanguay R, Hessel E, Ryan K. Zebrafish behavioral assessment as a first-tier whole-organism NAM for developmental neurotoxicity: A multi-laboratory evaluation. Neurotoxicology. 2026 Jul 02
]
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Hall L, Hsieh J, Marvel S, Behl M, Fritsche E, Koch K, Kreutz A, Leist M, Muriana A, Shafer T, Stanko J, Sills R, Hogberg H, McPherson C. Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment.
Neurotoxicology.
2026 Jul;115:103485.
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AbstractHall L, Hsieh J, Marvel S, Behl M, Fritsche E, Koch K, Kreutz A, Leist M, Muriana A, Shafer T, Stanko J, Sills R, Hogberg H, McPherson C. Prioritizing chemicals for developmental neurotoxicity by integrating data from a new approach methods (NAMs) battery covering key cellular events in neurodevelopment. Neurotoxicology. 2026 Jul
]
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Li L, Hwang J, Shockley K, Li Y, Motsinger-Reif A, Hsieh J, Auerbach S, Reif D. Tox21mer, A transformer foundation model for Tox21 high-throughput concentration-response curves data.
bioRxiv : the preprint server for biology.
2026 Jun 19 [Epub ahead of print].
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AbstractLi L, Hwang J, Shockley K, Li Y, Motsinger-Reif A, Hsieh J, Auerbach S, Reif D. Tox21mer, A transformer foundation model for Tox21 high-throughput concentration-response curves data. bioRxiv : the preprint server for biology. 2026 Jun 19
]
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Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.
Chemical research in toxicology.
2026 Apr 20;39(4):624-635.
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AbstractNgan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study. Chemical research in toxicology. 2026 Apr 20
]
