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Genome Integrity & Structural Biology Laboratory

When & Where:

TimeDay of WeekLocation
1:00 p.m.ThursdaysF193 unless indicated

2023

DateSpeakerTopic
September 7OPENOPEN
September 14Borgnia group: Venkata DandyTime-resolved Cryo-EM Using Acoustofluidics
September 21Bill CopelandOverview of Mitochondrial DNA Replication
September 28Dmitry GordeninMutational Signatures in DNA and in RNA Genomes
October 5Tom KunkelNew Studies of Nuclear DNA Replication Fidelity
October 12Scott WilliamsTopoisomerase DNA-protein Crosslink Repair
October 19Guest SpeakerProfessor Steven A. Roberts, University of Vermont. (Host: Dmitry Gordenin)
October 26Doetsch group: Anirba KarTBA
November 2Lars PedersenStructural Studies of the pmHS2 Heparosan Synthetase
November 9Kunkel group: Jessica WilliamsThe Mutagenic Cost of Low Fidelity DNA Ligation During Replication
November 16Guest SpeakerDr. Samantha Lewis, University of California Berkeley. (Host: Bill Copeland)
November 23Thanksgiving 
November 30Kunkel group: Mahina MonsurWhole Genome Study of Mutagenesis by S. cerevisiae Pol ζ
December 7Schaaper group: Niketa BhawsinghkaDuplex Sequencing to Investigate Mutations in E. coli
December 14Holiday party 
December 21Winter Break 
December 28Winter Break 

2024 (Leap year)

DateSpeakerTopic
January 4Lalith PereraMolecular Modeling at the NIEHS
January 11Williams group: Anand Jaguva VasudevanZATT Functions in TOP2 DNA Protein Crosslink Repair
January 18Doetsch group: Libertad GarciaTBA
January 25Kunkel group: Scott LujanWhole Genome Sequence Analysis of Replication Fidelity in Yeast
February 1Mueller group: Eugene DeRoseNMR of Problematic Proteins
February 8OPEN 
February 15Bob PetrovichProtein Expression and Purification at the NIEHS
February 22Copeland group: Dillon KingTFAM as a Mitochondrial DNA Damage Sensor
February 29Kunkel group: Sarah MarksAre Pol Alpha Errors Extrinsically Proofread by Pol Delta?
March 7Williams group: Percy TumbaleMolecular Basis for DNA Ligation Fidelity
March 14Doetsch group: Natasha DegtyarevaTBA
March 21Pedersen group: Guangning ZongStructural Studies Within the Structural Biology Core
March 28Schaaper group: Abra GrangerCharacterizing dGTPase Enzyme Function in E. coli Using Molecular Dynamic Simulations
April 4Mario Borgnia, Kedar SharmaStructural Characterization of Class I Protein Mediated Membrane Fusion
April 11Williams group: Oya BermekArchitecture of the Herpes Replisome
April 18Kunkel group: Hunter WilkinsThe Role of Exonuclease 1 in DNA Mismatch Repair
April 25Gordenin group: Matt DennenAPOBEC Mutagenesis in Yeast Model
May 2Paul DoetschTBA
May 9Kunkel group: Anu NairExamining the “Dislocation Hypothesis” with DNA Polymerase Theta
May 16Williams group: Dhakaram Pangeni SharmaRepair of TOP2 DNA Protein Crosslinks
May 23OPEN 
May 30Mario BorgniaSeven Years of cryo-EM at the NIEHS
June 6Kunkel group: Maggie HumbleHow Do Mutation Prone Polymerases Handle Oxidative Stress?
June 13Roel SchaaperInsertion Elements
June 20Williams group: Jessica WojtaszekApe2 Function in DNA Protein Crosslink Repair
June 27Geoffrey MuellerPeanut and Tree Nut Allergies: New Diagnostics and New Therapies
July 4July 4 Holiday 
July 11Kunkel group: Logan SchuckFixing Mismatches from Beginning to End: MMR at Telomeres
July 18Doetsch group: Avril PowellTBA
July 25OPEN