Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
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Janine H. Santos, Ph.D.
Staff Scientist
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Tel 984-287-4008
[email protected]
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P.O. Box 12233
Mail Drop C2-02
Durham, NC 27709
Janine leads the Mitochondria Toxicology and Biology Group in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Her group’s research focuses on how mitochondria can broadly impact cellular and health outcomes through their impact on epigenetics, particularly DNA methylation. The group also uses animal models of perinatal exposures, including using drugs/chemicals that affect mitochondria like HIV therapeutics, to establish translatability of the effects both in the context of maternal health and long-term fetal outcomes.
Janine obtained her Bachelor of Science in biology from the Pontifícia Universidade Católica do Rio Grande do Sul, followed by a Ph.D. in Genetic Toxicology from the Universidade Federal do Rio Grande do Sul, in Porto Alegre, Brazil. She did postdoctoral fellowship at NIEHS and was an Assistant Professor at the New Jersey Medical School before starting her work at DTT.
Selected Publications
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Hasan P, Berezhnaya E, Rodríguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, Birch E, Beyer A, Santos J, Seifert E, Elrod J, Hajnóczky G. MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Aug 27;121(35):e2402491121.
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AbstractHasan P, Berezhnaya E, Rodríguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, Birch E, Beyer A, Santos J, Seifert E, Elrod J, Hajnóczky G. MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart. Proceedings of the National Academy of Sciences of the United States of America. 2024 Aug 27
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Mori M, Lozoya O, Brooks A, Grenet D, Nadalutti C, Ryback B, Huang K, Hasan P, Hajnóczky G, Santos J. Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling.
bioRxiv : the preprint server for biology.
2024 Jan 13 [Epub ahead of print].
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AbstractMori M, Lozoya O, Brooks A, Grenet D, Nadalutti C, Ryback B, Huang K, Hasan P, Hajnóczky G, Santos J. Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling. bioRxiv : the preprint server for biology. 2024 Jan 13
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Gál A, Santos J, Molnár M, Hajnóczky G. Answer to Gerber et al. "Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy".
EMBO molecular medicine.
2023 Aug 07;15(8):e16251.
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AbstractGál A, Santos J, Molnár M, Hajnóczky G. Answer to Gerber et al. "Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy". EMBO molecular medicine. 2023 Aug 07
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Rickard B, Overchuk M, Chappell V, Kemal Ruhi M, Sinawang P, Nguyen Hoang T, Akin D, Demirci U, Franco W, Fenton S, Santos J, Rizvi I. Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer.
Cancers.
2023 Apr 29;15(9):.
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AbstractRickard B, Overchuk M, Chappell V, Kemal Ruhi M, Sinawang P, Nguyen Hoang T, Akin D, Demirci U, Franco W, Fenton S, Santos J, Rizvi I. Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer. Cancers. 2023 Apr 29
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Rickard B, Overchuk M, Obaid G, Ruhi M, Demirci U, Fenton S, Santos J, Kessel D, Rizvi I. Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer †.
Photochemistry and photobiology.
2023 Mar;99(2):448-468.
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AbstractRickard B, Overchuk M, Obaid G, Ruhi M, Demirci U, Fenton S, Santos J, Kessel D, Rizvi I. Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer †. Photochemistry and photobiology. 2023 Mar
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More Recent Publications from PubMed
