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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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Arun Kumar R. Pandiri, B.V.Sc. & A.H., M.S., Ph.D., D.A.C.V.P., D.A.B.T.
Arun Kumar R. Pandiri, B.V.Sc. & A.H., M.S., Ph.D., D.A.C.V.P., D.A.B.T.
Group Leader - Pathologist
Tel 984-287-3861
[email protected]
P.O. Box 12233
Mail Drop B3-06
Durham, NC 27709
Laser Capture Microdissection - Comparative and Molecular Pathogenesis Branch

Laser Microdissection core laboratory aids in the extraction of defined cells and tissues to allow target-based research. The laboratory will also assist in the extraction of DNA, RNA or protein from specific cells or tissues of interest to aid the NIEHS investigators in their research. The LCM lab works closely with the Pathology Support Core Laboratory, Microarray Core Laboratory, Epigenomics and DNA Sequencing Core Laboratory and Mass Spectrometry Research and Support Group to develop protocols for the analysis of biomolecules in frozen or formalin-fixed paraffin-embedded tissues.

Selected Publications

  1. Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G. CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State. Stem Cell Report 2016, 7: 1-14 [Abstract ]
  2. Dunnick JK, Merrick BA, Brix A, Morgan DL, Gerrish K, Wang Y, Flake G, Foley J, Shockley KR. Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure. Toxicologic Pathology, 2016, 44: 835-847 [Abstract ]
  3. Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ. Genomic profiling reveals unique molecular alterations in hepatoblastomas and adjacent hepatocellular carcinomas in B6C3F1 Mice. Toxicological Pathology 2015 43(8): 1114-1126. [Abstract ]
  4. Harvey JB, Hong HH, Bhusari S, Ton TV, Wang Y, Foley JF, Peddada SD, Hooth M, DeVito M, Nyska A, Pandiri AR, Hoenerhoff MJ. F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation. Veterinary Pathology March 2, 2015. [Abstract ]
  5. Morgan DL, Merrick BA, Gerrish KE, Stockton PS, Wang Y, Foley JF, Gwinn WM, Kelly FL, Palmer SM, Ton TT, Flake GP. Gene Expression in Obliterative Bronchiolitis-Like Lesions in 2,3-Pentanedione-Exposed Rats. Plos One Feb 24;10(2) 2015. [Abstract ]
  6. Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth MJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ. 2014. Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4"-tetrachloroazobenzene. Toxicology Pathology 42(3):555-64. [Abstract ]
  7. Binder AK, Rodriguez KF, Hamilton KJ, Stockton PS, Reed CE, Korach KS. The Absence of ERβ Results in Altered Gene Expression in Ovarian Granulosa Cells Isolate From In Vivo Preovulatory Follicles Endocrinology June 2013, 154(6):2174 [Abstract ]
  8. Stockton P. Laser Microdissection for the Histology Technician. Histologic 39(1) May 2006
  9. Flake GP, Rivera MP, Funkhouser WK, Slebos RJC, Maygarden SJ, Meadows KL, Long EH, Stockton PS, Jones TC, Taylor JA. Detection of pre-invasive lung cancer: Technical aspects of the LIFE Project. Toxicologic Pathology 2007 35:65-74. [Abstract ]
  10. Greene S, Stockton P, Kozyreva OG, Gaston KE, Flake GP, Mohler JL. Mutational Analysis of the Androgen Receptor Using Laser Capture Microdissection and Direct Sequencing. Methods Mol Biol 218:287-302, 2003. [Abstract ]
  11. Torres-Munoz J, Stockton P, Tacoronte N, Roberts B, Maronpot R, Petito C. Detection of HIV-1 Gene Sequences in Hippocampal Neurons Isolated From Postmortem AIDS Brain by Laser Capture Microdissection. J Neuropath and Exp Neurol 60(9), 2001. [Abstract ]
  12. Slebos RJ, Hoppin JA, Tolbert PE, Holly EA, Brock JW, Zhang RH, Bracci PM, Foley J, Stockton P, McGregor LM, Flake GP, Taylor JA. K-ras and p53 in Pancreatic Cancer: Association with Medical History, Histopathology and Environmental Exposures in a Population-based Study. NIEHS Cancer, Epidemiology, Biomarkers and Prevention (AACR) Vol. 9, 1223-1232, Nov. 2000. [Abstract ]
  13. Anna CH, Sills RC, Foley JF, Stockton PS, Ton T-V, Devereux TR. β-catenin Mutations and Protein Accumulation in All Chemically Induced Hepatoblastomas Examined From B6C3F1 Mice. Cancer Res April 2000. [Abstract ]
  14. Patel AC, Anna CH, Foley JF, Stockton PS, Tyson FL, Barrett JC, Devereux TR. Hypermethylation of p16Ink4a in B6C3F1 Mouse Lung Adenocarcinomas and Mouse Lung Tumor Derived Cell Lines. Mol Carcinogenesis (21)9; 2000. [Abstract ]
  15. Goldwsorthy SM, Stockton PS, Trempus CS, Foley JF, Maronpot RR. Effects of Fixation on RNA Extraction and Amplification from Laser Capture Microdissected Tissue. Mol Carcin June 1999. [Abstract ]