Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
-
-
Arun Kumar R. Pandiri, B.V.Sc. & A.H., M.S., Ph.D., D.A.C.V.P., D.A.B.T.
Group Leader - Pathologist -
Tel 984-287-3861
[email protected] -
P.O. Box 12233Mail Drop B3-06Durham, NC 27709
Laser Microdissection core laboratory aids in the extraction of defined cells and tissues to allow target-based research. The laboratory will also assist in the extraction of DNA, RNA or protein from specific cells or tissues of interest to aid the NIEHS investigators in their research. The LCM lab works closely with the Pathology Support Core Laboratory, Microarray Core Laboratory, Epigenomics and DNA Sequencing Core Laboratory and Mass Spectrometry Research and Support Group to develop protocols for the analysis of biomolecules in frozen or formalin-fixed paraffin-embedded tissues.
Recent Publications
- Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 22;44(7):115978. [ AbstractXu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 22 ]
- Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer research. 2025 May 15;85(10):1769-1783. [ AbstractCai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer research. 2025 May 15 ]
- Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024;19(1):e0296699. [ AbstractBrooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024 ]
- Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver. Toxicologic pathology. 2023 Oct;51(7-8):470-481. [ AbstractPandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver. Toxicologic pathology. 2023 Oct ]
- Izawa T, Travlos G, Cortes R, Clayton N, Sills R, Pandiri A. Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. Toxicologic pathology. 2023 Apr;51(3):112-125. [ AbstractIzawa T, Travlos G, Cortes R, Clayton N, Sills R, Pandiri A. Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. Toxicologic pathology. 2023 Apr ]
NTP Reports
- National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun ]
- National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar ]
- National Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2018 Jun [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2018 Jun ]
- National Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2017 Dec [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2017 Dec ]
- National Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Apr [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Apr ]