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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

Systems Toxicology Branch

Stephanie Smith-Roe, Ph.D., is a genetic toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at NIEHS. Smith-Roe designs genetic toxicity testing strategies for the DTT and serves as the Contracting Officer’s Representative for the program’s Genetic Toxicity Testing Contract. She is the lead study scientist for the in vitro genetic toxicity testing of glyphosate (the active herbicide in Roundup products) and has investigated the genotoxic effects of other high-profile substances such as radiofrequency radiation and botanical dietary supplements. Smith-Roe has contributed to the Toxicology in the 21st Century quantitative high-throughput screening effort to prioritize chemicals for further testing, focusing on assays that detect DNA damage. Her expertise has been recognized internationally, and she has served as an International Agency for Research on Cancer (IARC) monograph work group participant.

Smith-Roe acquired training in toxicology and molecular biology in the pursuit of understanding the causes and consequences of genomic instability, with an emphasis on the effects of environmental exposures. Smith-Roe received a B.S. in Zoology and Psychology (specializing in biochemistry and neuroscience) from the University of Wisconsin-Madison, obtained her Ph.D. in Environmental and Molecular Toxicology from Oregon State University, and held a Curriculum in Toxicology Postdoctoral Fellowship at the University of North Carolina at Chapel Hill. Altogether, she has published in the areas of genetic toxicology, mutagenesis, carcinogenesis, DNA replication and repair, DNA damage signaling, chromatin remodeling, and behavioral neuroscience.

Smith-Roe is active in scientific societies and organizations dedicated to research and issues related to genetic toxicology, genomic stability, and carcinogenesis. She is currently President of the Environmental Mutagenesis and Genomics Society (EMGS), where she has co-chaired several symposia, served as a Councilor to the Executive Board, and co-chaired or served on numerous committees, special interest groups, and task forces. Smith-Roe serves on the Editorial Boards for Environmental and Molecular Mutagenesis (the journal of the EMGS) and Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Additionally, she is an active participant in the Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC). Smith-Roe is a Past President of the Genetics and Environmental Mutagenesis Society (GEMS), headquartered in Research Triangle Park, North Carolina.

Selected Publications