Monday October 2 – Industry and Academic Partners
Monday, October 16 – Non-governmental Organization Representatives
Monday, October 30 – U.S. Government and International Partners

NIH Listening Sessions on “Complement Animal Research in Experimentation (Complement-ARIE)”

The NIH gathered input to inform a potential Common Fund research program called “Complement Animal Research in Experimentation (Complement-ARIE)” aimed at development, standardization, validation, and use of new approach methodologies (NAMs). These NAMs are intended to more accurately model human biology, and will complement, or in some cases replace, traditional models, transforming the way we do basic, translational, and clinical sciences.

The NIH Common Fund hosted three listening sessions to gather input on the Complement-ARIE concept and potential opportunities for partnership, collaboration, and coordination among multiple sectors of government, industry, academia, and NGOs.

Sessions explored these questions:

  • Where are animal models insufficient to answer questions about human biology and disease?
  • What are the specific areas of science that could benefit from development of human-relevant NAMs?
  • Where do NAMs show promise in modeling population diversity and susceptibility and what additional research is needed to further those objectives?
  • What are the greatest opportunities for progress in NAMs in the next five years? In the next ten years?
  • What are current limitations of NAMs and how could they be addressed?
  • What’s needed for successful application and utility of NAMs and what are obstacles to implementation?
  • What are the challenges and needs around validation of NAMs for regulatory application?

More Information

Please send your questions to [email protected].

Learn more at the Common Fund website.

And sign up for the Complement-ARIE listserv to hear about new announcements.