Placental Cell Biology Group
Highlighted Publications
- Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun 12(1):6750. doi: 10.1038/s41467-021-26999-x. [ Abstract Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun 12(1):6750. doi: 10.1038/s41467-021-26999-x. ]
- Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Rep 31(13):107837. doi: 10.1016/j.celrep.2020.107837. [ Abstract Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Rep 31(13):107837. doi: 10.1016/j.celrep.2020.107837. ]
- Guardia CM, Kane E, Tebo AG, Sanders AAWM, Kaya D, Grogan KE. 2023. The power of peer networking for improving STEM faculty job applications: a successful pilot programme. Proc Biol Sci 290(1997):20230124. doi: 10.1098/rspb.2023.0124. Epub 2023 Apr 26. [ Abstract Guardia CM, Kane E, Tebo AG, Sanders AAWM, Kaya D, Grogan KE. 2023. The power of peer networking for improving STEM faculty job applications: a successful pilot programme. Proc Biol Sci 290(1997):20230124. doi: 10.1098/rspb.2023.0124. Epub 2023 Apr 26. ]
Original Research Articles
- Couto PM, Guardia CMA, Couto FL, Labriola CA, Labanda MS, Caramelo JJ^. 2024. Acceptors stability modulates the efficiency of post-translational protein N-glycosylation. FASEB J 15;38(13):e23782. doi: 10.1096/fj.202302267R. [ Abstract Couto PM, Guardia CMA, Couto FL, Labriola CA, Labanda MS, Caramelo JJ^. 2024. Acceptors stability modulates the efficiency of post-translational protein N-glycosylation. FASEB J 15;38(13):e23782. doi: 10.1096/fj.202302267R. ]
- Guardia CM, Kane E, Tebo AG, Sanders AAWM, Kaya D, Grogan KE^. 2023. The power of peer networking for improving STEM faculty job applications: a successful pilot programme. Proc Biol Sci 26;290(1997):20230124. doi: 10.1098/rspb.2023.0124. Epub 2023 Apr 26. [ Abstract Guardia CM, Kane E, Tebo AG, Sanders AAWM, Kaya D, Grogan KE^. 2023. The power of peer networking for improving STEM faculty job applications: a successful pilot programme. Proc Biol Sci 26;290(1997):20230124. doi: 10.1098/rspb.2023.0124. Epub 2023 Apr 26. ]
- Ishida M, Otero MG, Freeman C, Sánchez-Lara PA, Guardia CM, Pierson TM^, Bonifacino JS^. 2023. A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1. Hum Mol Genet 20;32(7):1162-1174. doi: 10.1093/hmg/ddac279. [ Abstract Ishida M, Otero MG, Freeman C, Sánchez-Lara PA, Guardia CM, Pierson TM^, Bonifacino JS^. 2023. A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1. Hum Mol Genet 20;32(7):1162-1174. doi: 10.1093/hmg/ddac279. ]
- Hu G*, Hauk PJ*, Zhang N, Elsegeiny W, Guardia CM, Kullas A, Crosby K, Deterding RR, Schedel M, Reynolds P, Abbott JK, Knight V, Pittaluga S, Raffeld M, Rosenzweig SD, Bonifacino JS, Uzel G, Williamson PR^, Gelfand EW. 2023. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A. Autophagy 19(2):678-691. doi: 10.1080/15548627.2022.2093028. Epub 2022 Jul 15. [ Abstract Hu G*, Hauk PJ*, Zhang N, Elsegeiny W, Guardia CM, Kullas A, Crosby K, Deterding RR, Schedel M, Reynolds P, Abbott JK, Knight V, Pittaluga S, Raffeld M, Rosenzweig SD, Bonifacino JS, Uzel G, Williamson PR^, Gelfand EW. 2023. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A. Autophagy 19(2):678-691. doi: 10.1080/15548627.2022.2093028. Epub 2022 Jul 15. ]
- Ahmad T, Vullhorst D, Chaudhuri R, Guardia CM, Chaudhary N, Karavanova I, Bonifacino JS, Buonanno A^. 2022. Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3. J Cell Biol 4;221(7):e202110167. doi: 10.1083/jcb.202110167. Epub 2022 May 17. [ Abstract Ahmad T, Vullhorst D, Chaudhuri R, Guardia CM, Chaudhary N, Karavanova I, Bonifacino JS, Buonanno A^. 2022. Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3. J Cell Biol 4;221(7):e202110167. doi: 10.1083/jcb.202110167. Epub 2022 May 17. ]
- Williamson CD, Guardia CM, De Pace R, Bonifacino JS, Saric A^. 2022. Measurement of Lysosome Positioning by Shell Analysis and Line Scan. Methods Mol Biol 2473:285-306. doi: 10.1007/978-1-0716-2209-4_19. [ Abstract Williamson CD, Guardia CM, De Pace R, Bonifacino JS, Saric A^. 2022. Measurement of Lysosome Positioning by Shell Analysis and Line Scan. Methods Mol Biol 2473:285-306. doi: 10.1007/978-1-0716-2209-4_19. ]
- Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets at sites of phagophore formation. Nat Commun 12(1):6750. doi: 10.1038/s41467-021-26999-x. [ Abstract Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets at sites of phagophore formation. Nat Commun 12(1):6750. doi: 10.1038/s41467-021-26999-x. ]
- Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. 2021. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell 32(21):ar25. doi: 10.1091/mbc.E21-06-0295. Epub 2021 Aug 25. [ Abstract Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. 2021. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell 32(21):ar25. doi: 10.1091/mbc.E21-06-0295. Epub 2021 Aug 25. ]
- Dilsizoglu Senol A*, Samarani M*, Syan S, Guardia CM, Nonaka T, Liv N, Latour-Lambert P, Hasegawa M, Klumperman J, Bonifacino JS, Zurzolo C. 2021. α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes. PLoS Biol 19(7):e3001287. doi: 10.1371/journal.pbio.3001287. [ Abstract Dilsizoglu Senol A*, Samarani M*, Syan S, Guardia CM, Nonaka T, Liv N, Latour-Lambert P, Hasegawa M, Klumperman J, Bonifacino JS, Zurzolo C. 2021. α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes. PLoS Biol 19(7):e3001287. doi: 10.1371/journal.pbio.3001287. ]
- Saric A, Freeman SA, Williamson CD, Jarnik M, Guardia CM, Fernandopulle MS, Gershlick DC, Bonifacino JS. 2021. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun 12(1):4552. doi: 10.1038/s41467-021-24709-1. [ Abstract Saric A, Freeman SA, Williamson CD, Jarnik M, Guardia CM, Fernandopulle MS, Gershlick DC, Bonifacino JS. 2021. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun 12(1):4552. doi: 10.1038/s41467-021-24709-1. ]
- Guardia CM*, Tan XF*, Lian T*, Rana MS*, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Rep 31(13):107837. doi: 10.1016/j.celrep.2020.107837. [ Abstract Guardia CM*, Tan XF*, Lian T*, Rana MS*, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Rep 31(13):107837. doi: 10.1016/j.celrep.2020.107837. ]
- Guardia CM, De Pace R, Sen A, Saric A, Jarnik M, Kolin DA, Kunwar A, Bonifacino JS. 2019. Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning. PLoS Biol 17(5):e3000279. doi: 10.1371/journal.pbio.3000279. [ Abstract Guardia CM, De Pace R, Sen A, Saric A, Jarnik M, Kolin DA, Kunwar A, Bonifacino JS. 2019. Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning. PLoS Biol 17(5):e3000279. doi: 10.1371/journal.pbio.3000279. ]
- Sharma G*, Guardia CM*, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML. 2019. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy 15(10):1694-1718. doi: 10.1080/15548627.2019.1586257. Epub 2019 Mar 8. [ Abstract Sharma G*, Guardia CM*, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML. 2019. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy 15(10):1694-1718. doi: 10.1080/15548627.2019.1586257. Epub 2019 Mar 8. ]
- Mattera R*, Park SY*, De Pace R, Guardia CM, Bonifacino JS. 2017. AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation. Proc Natl Acad Sci U S A 114(50):E10697-E10706. doi: 10.1073/pnas.1717327114. Epub 2017 Nov 27. [ Abstract Mattera R*, Park SY*, De Pace R, Guardia CM, Bonifacino JS. 2017. AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation. Proc Natl Acad Sci U S A 114(50):E10697-E10706. doi: 10.1073/pnas.1717327114. Epub 2017 Nov 27. ]
- Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS. 2017. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy 13(10):1648-1663. doi: 10.1080/15548627.2017.1343768. Epub 2017 Aug 21. [ Abstract Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS. 2017. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy 13(10):1648-1663. doi: 10.1080/15548627.2017.1343768. Epub 2017 Aug 21. ]
- Farías GG, Guardia CM, De Pace R, Britt DJ, Bonifacino JS. 2017. BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon. Proc Natl Acad Sci U S A 114(14):E2955-E2964. doi: 10.1073/pnas.1616363114. Epub 2017 Mar 20. [ Abstract Farías GG, Guardia CM, De Pace R, Britt DJ, Bonifacino JS. 2017. BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon. Proc Natl Acad Sci U S A 114(14):E2955-E2964. doi: 10.1073/pnas.1616363114. Epub 2017 Mar 20. ]
- Guardia CM, Farías GG, Jia R, Pu J, Bonifacino JS. 2016. BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks. Cell Rep 17(8):1950-1961. doi: 10.1016/j.celrep.2016.10.062. [ Abstract Guardia CM, Farías GG, Jia R, Pu J, Bonifacino JS. 2016. BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks. Cell Rep 17(8):1950-1961. doi: 10.1016/j.celrep.2016.10.062. ]
- Farías GG, Guardia CM, Britt DJ, Guo X, Bonifacino JS. 2015. Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone. Cell Rep 13(6):1221-1232. doi: 10.1016/j.celrep.2015.09.074. Epub 2015 Oct 29. [ Abstract Farías GG, Guardia CM, Britt DJ, Guo X, Bonifacino JS. 2015. Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone. Cell Rep 13(6):1221-1232. doi: 10.1016/j.celrep.2015.09.074. Epub 2015 Oct 29. ]
- Mattera R, Guardia CM, Sidhu SS, Bonifacino JS. 2015. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. J Biol Chem 290(52):30736-49. doi: 10.1074/jbc.M115.683409. Epub 2015 Nov 5. [ Abstract Mattera R, Guardia CM, Sidhu SS, Bonifacino JS. 2015. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. J Biol Chem 290(52):30736-49. doi: 10.1074/jbc.M115.683409. Epub 2015 Nov 5. ]
- Guardia CM, Caramelo JJ, Trujillo M, Méndez-Huergo SP, Radi R, Estrin DA, Rabinovich GA. 2014. Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 24(5):428-41. doi: 10.1093/glycob/cwu008. Epub 2014 Jan 21. [ Abstract Guardia CM, Caramelo JJ, Trujillo M, Méndez-Huergo SP, Radi R, Estrin DA, Rabinovich GA. 2014. Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 24(5):428-41. doi: 10.1093/glycob/cwu008. Epub 2014 Jan 21. ]
- Guardia CM, Gauto DF, Di Lella S, Rabinovich GA, Martí MA, Estrin DA. 2011. An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network. J Chem Inf Model 51(8):1918-30. doi: 10.1021/ci200180h. Epub 2011 Jul 15. Cover of the Issue. [ Abstract Guardia CM, Gauto DF, Di Lella S, Rabinovich GA, Martí MA, Estrin DA. 2011. An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network. J Chem Inf Model 51(8):1918-30. doi: 10.1021/ci200180h. Epub 2011 Jul 15. Cover of the Issue. ]
- Di Lella S, Martí MA, Croci DO, Guardia CM, Díaz-Ricci JC, Rabinovich GA, Caramelo JJ, Estrin DA. 2010. Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria. Biochemistry 49(35):7652-8. doi: 10.1021/bi100356g. [ Abstract Di Lella S, Martí MA, Croci DO, Guardia CM, Díaz-Ricci JC, Rabinovich GA, Caramelo JJ, Estrin DA. 2010. Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria. Biochemistry 49(35):7652-8. doi: 10.1021/bi100356g. ]
- Gauto DF, Di Lella S, Guardia CM, Estrin DA, Martí MA. 2009. Carbohydrate-binding proteins: Dissecting ligand structures through solvent environment occupancy. J Phys Chem B. 2009 Jun 25;113(25):8717-24. doi: 10.1021/jp901196n. [ Abstract Gauto DF, Di Lella S, Guardia CM, Estrin DA, Martí MA. 2009. Carbohydrate-binding proteins: Dissecting ligand structures through solvent environment occupancy. J Phys Chem B. 2009 Jun 25;113(25):8717-24. doi: 10.1021/jp901196n. ]
- Guardia CMA, González Lebrero MC, Bari SE, Estrin DA. 2008. QM/MM investigation of the reaction products between nitroxyl and O2 in aqueous solution. Chem Phys Lett 463, 112-16. [ Abstract Guardia CMA, González Lebrero MC, Bari SE, Estrin DA. 2008. QM/MM investigation of the reaction products between nitroxyl and O2 in aqueous solution. Chem Phys Lett 463, 112-16. ]
Complete list of publications on Google Scholar & PubMed.
Book Chapters, Review Articles, and Editorials
- Guardia CM^, Hierro A, Gershlick DC^. 2021. Editorial: Energy Requirements in Membrane Trafficking. Front Cell Dev Biol 9:750633. doi: 10.3389/fcell.2021.750633. [ Abstract Guardia CM^, Hierro A, Gershlick DC^. 2021. Editorial: Energy Requirements in Membrane Trafficking. Front Cell Dev Biol 9:750633. doi: 10.3389/fcell.2021.750633. ]
- Nieto-Torres JL*, Durgan J*, Franco-Romero A*, Grumati P*, Guardia CM*, Leidal AM*, Mandell MA*, Towers CG*, Wang F*. 2021. The Autophagy, Inflammation and Metabolism Center international eSymposium - an early-career investigators' seminar series during the COVID-19 pandemic. J Cell Sci 134(19):jcs259268. doi: 10.1242/jcs.259268. Epub 2021 Oct 8. [ Abstract Nieto-Torres JL*, Durgan J*, Franco-Romero A*, Grumati P*, Guardia CM*, Leidal AM*, Mandell MA*, Towers CG*, Wang F*. 2021. The Autophagy, Inflammation and Metabolism Center international eSymposium - an early-career investigators' seminar series during the COVID-19 pandemic. J Cell Sci 134(19):jcs259268. doi: 10.1242/jcs.259268. Epub 2021 Oct 8. ]
- Klionsky DJ, et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy 17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. [ Abstract Klionsky DJ, et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy 17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. ]
- Guardia CM*, Christenson ET*, Zhou W, Tan XF, Lian T, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. The structure of human ATG9A and its interplay with the lipid bilayer. Autophagy 16(12):2292-2293. doi: 10.1080/15548627.2020.1830522. Epub 2020 Oct 16. [ Abstract Guardia CM*, Christenson ET*, Zhou W, Tan XF, Lian T, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. The structure of human ATG9A and its interplay with the lipid bilayer. Autophagy 16(12):2292-2293. doi: 10.1080/15548627.2020.1830522. Epub 2020 Oct 16. ]
- Guardia CM, De Pace R, Mattera R, Bonifacino JS. 2018. Neuronal functions of adaptor complexes involved in protein sorting. Curr Opin Neurobiol 51:103-110. doi: 10.1016/j.conb.2018.02.021. Epub 2018 Mar 17. [ Abstract Guardia CM, De Pace R, Mattera R, Bonifacino JS. 2018. Neuronal functions of adaptor complexes involved in protein sorting. Curr Opin Neurobiol 51:103-110. doi: 10.1016/j.conb.2018.02.021. Epub 2018 Mar 17. ]
- Pu J, Guardia CM, Keren-Kaplan T, Bonifacino JS. 2016. Mechanisms and functions of lysosome positioning. J Cell Sci 129(23):4329-4339. doi: 10.1242/jcs.196287. Epub 2016 Oct 31. [ Abstract Pu J, Guardia CM, Keren-Kaplan T, Bonifacino JS. 2016. Mechanisms and functions of lysosome positioning. J Cell Sci 129(23):4329-4339. doi: 10.1242/jcs.196287. Epub 2016 Oct 31. ]
- Britt DJ, Farías GG, Guardia CM, Bonifacino JS. 2016. Mechanisms of Polarized Organelle Distribution in Neurons. Front Cell Neurosci 10:88. doi: 10.3389/fncel.2016.00088. [ Abstract Britt DJ, Farías GG, Guardia CM, Bonifacino JS. 2016. Mechanisms of Polarized Organelle Distribution in Neurons. Front Cell Neurosci 10:88. doi: 10.3389/fncel.2016.00088. ]
- Zeida A, Guardia CM, Lichtig P, Perissinotti LL, Defelipe LA, Turjanski A, Radi R, Trujillo M, Estrin DA. 2014. Thiol redox biochemistry: insights from computer simulations. Biophys Rev 6(1):27-46. doi: 10.1007/s12551-013-0127-x. Epub 2014 Jan 9. [ Abstract Zeida A, Guardia CM, Lichtig P, Perissinotti LL, Defelipe LA, Turjanski A, Radi R, Trujillo M, Estrin DA. 2014. Thiol redox biochemistry: insights from computer simulations. Biophys Rev 6(1):27-46. doi: 10.1007/s12551-013-0127-x. Epub 2014 Jan 9. ]
- Di Lella S, Sundblad V, Cerliani JP, Guardia CM, Estrin DA, Vasta GR, Rabinovich GA. 2011. When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50(37):7842-57. doi: 10.1021/bi201121m. Epub 2011 Aug 26. [ Abstract Di Lella S, Sundblad V, Cerliani JP, Guardia CM, Estrin DA, Vasta GR, Rabinovich GA. 2011. When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50(37):7842-57. doi: 10.1021/bi201121m. Epub 2011 Aug 26. ]
Total Citations: 2494 & H-index: 21; *Equal Contribution; ^Corresponding Author