Exposure, Response, and Technology Branch (ERTB)

Daniel T. Shaughnessy, Ph.D.
Daniel T. Shaughnessy, Ph.D.
Health Scientist Administrator
Tel 984-287-3321
Fax 919-541-0146
[email protected]
P.O. Box 12233
Mail Drop K3-04
Durham, NC 27709

Daniel Shaughnessy, Ph.D., joined the Division of Extramural Research and Training in 2006. As a postdoctoral fellow in the Laboratory of Molecular Carcinogenesis at NIEHS, he conducted research on the risks and protective effects of dietary factors on DNA damage in humans. He received a Ph.D. from the University of North Carolina at Chapel Hill in 2002 and an MSPH degree from UNC in 2000, studying the molecular mechanisms of environmental mutagens and dietary antimutagens.

Shaughnessy manages a portfolio of grants related to DNA damage and repair and mutagenesis, effects of oxidative stress on mutagenic and carcinogenic pathways, and translation control of response to environmental stress. He also manages grants on the development and validation of biomarkers of response to environmental stress, with a continuing focus on early biomarkers of mitochondrial dysfunction and altered signaling in response to environmental stress. He is the program lead for the small business programs (SBIR/STTR) at NIEHS, focused on supporting small business grants for improved exposure assessment, predictive toxicology tools for hazard assessment, and intervention technologies to reduce exposure to environmental contaminants.

Shaughnessy is an active member of several Common Fund programs, including the NIH Common Fund program on Somatic Mosaicism across Human Tissues (SMaHT), the NIEHS-NCI Cancer and the Environment Working Group, and the trans-agency National Emerging Contaminants Research Initiative.

Areas of Specialty:

Selected Publications:

  1. Beger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu PC, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O'Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Spalholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA. 2019. Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics doi: 10.1007/s11306-018-1460-7 [Online 3 January 2019]. [Abstract Beger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu PC, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O'Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Spalholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA. 2019. Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics doi: 10.1007/s11306-018-1460-7 [Online 3 January 2019].]
  2. Shaughnessy DT1, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives 2014 122(12):1271-1278. [Abstract Shaughnessy DT1, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives 2014 122(12):1271-1278.]
  3. Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. Harnessing genomics to identify environmental determinants of heritable disease. Mutation research 2013 752(1):6-9. [Abstract Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. Harnessing genomics to identify environmental determinants of heritable disease. Mutation research 2013 752(1):6-9.]
  4. Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B, Knize MG, Matthews PP, Swank AE, Sandler RS, DeMarini DM, Taylor JA. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One. 2011 Apr 25;6(4):e18707. [Abstract Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B, Knize MG, Matthews PP, Swank AE, Sandler RS, DeMarini DM, Taylor JA. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One. 2011 Apr 25;6(4):e18707.]
  5. Shaughnessy DT, Worth L Jr, Lawler CP, McAllister KA, Longley MJ, Copeland WC. Meeting report: Identification of biomarkers for early detection of mitochondrial dysfunction. Mitochondrion. 2010 Aug;10(5):579-81. Epub 2010 Mar 1. [Abstract Shaughnessy DT, Worth L Jr, Lawler CP, McAllister KA, Longley MJ, Copeland WC. Meeting report: Identification of biomarkers for early detection of mitochondrial dysfunction. Mitochondrion. 2010 Aug;10(5):579-81. Epub 2010 Mar 1.]