Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Branch
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June K. Dunnick, Ph.D.
Project Manager - Toxicologist -
Tel 984-287-3124
Fax 919-541-4255
[email protected] -
P.O. Box 12233Mail Drop K2-02Durham, NC 27709
June K. Dunnick, Ph.D., is a toxicologist in the Toxicology Branch, which promotes, designs and administers research programs to understand how environmental exposures affect the public’s health. Research is focused on identifying and evaluating the beneficial and harmful effects of environmental chemicals, drugs, metals and other chemicals of concern so that strategies can be developed to prevent exposures to harmful agents or to develop disease prevention strategies particularly for cancer, reproductive disease, and infectious diseases. This involves the design, analysis, and interpretation of experimental studies to identify biological effects, and extrapolation of results to man through the use metabolism/pharmacokinetic studies and mechanistic studies. Her responsibilities include serving as senior scientist for toxicologic and carcinogenesis studies and identifying new initiatives for the development of a better understanding of environmental disease, through the integration, extrapolation and analysis of data from a broad range of experimental studies. She also serves as a focus, representative and spokesperson for the institute when reporting the findings from toxicology and carcinogenesis research studies.
Dr. Dunnick received a B.S. from Cornell University, Ithaca, New York , a Ph.D. from Cornell University Medical College, New York, New York, and a MBA from Kenan-Flagler Business School, UNC, Chapel Hill, NC. She completed postdoctoral work in the Department of Biochemistry, University of Rochester Medical School, Rochester, New York. Dr. Dunnick is a Diplomat of the American Board of Toxicology.
Recent Publications
- Ooka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, Hsieh J, Collins B, Dunnick J, Dixon D, Xia M. Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action. Environmental science & technology. 2025 Mar 18;59(10):4778-4787. [ AbstractOoka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, Hsieh J, Collins B, Dunnick J, Dixon D, Xia M. Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action. Environmental science & technology. 2025 Mar 18 ]
- Shockley K, Dunnick J. Gene expression profiling after exposure to a chemical carcinogen, Pentabrominated Diphenyl Ether, at different life stages. Frontiers in toxicology. 2022;4:1028309. [ AbstractShockley K, Dunnick J. Gene expression profiling after exposure to a chemical carcinogen, Pentabrominated Diphenyl Ether, at different life stages. Frontiers in toxicology. 2022 ]
- Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct;128:104812. [ AbstractDunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct ]
- Shockley K, Cora M, Malarkey D, Jackson-Humbles D, Vallant M, Collins B, Mutlu E, Robinson V, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick J. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicology letters. 2020 Oct 10;332:222-234. [ AbstractShockley K, Cora M, Malarkey D, Jackson-Humbles D, Vallant M, Collins B, Mutlu E, Robinson V, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick J. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicology letters. 2020 Oct 10 ]
- Shockley K, Cora M, Malarkey D, Jackson-Humbles D, Vallant M, Collins B, Mutlu E, Robinson V, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick J. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data in brief. 2020 Oct;32:106136. [ AbstractShockley K, Cora M, Malarkey D, Jackson-Humbles D, Vallant M, Collins B, Mutlu E, Robinson V, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick J. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data in brief. 2020 Oct ]
NTP Reports
- National Toxicology Program. Toxicity studies of tetrabromobisphenol A-bis(2,3-dibromopropyl ether) administered by gavage to F344/NTac rats and B6C3F1/N mice. Toxicity report series. 2017 Aug [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of tetrabromobisphenol A-bis(2,3-dibromopropyl ether) administered by gavage to F344/NTac rats and B6C3F1/N mice. Toxicity report series. 2017 Aug ]
- National Toxicology Program. Toxicity studies of p-toluenesulfonamide administered in feed to F344/N rats, F344/NTac rats, and B6C3F1/N mice. Toxicity report series. 2016 Aug [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of p-toluenesulfonamide administered in feed to F344/N rats, F344/NTac rats, and B6C3F1/N mice. Toxicity report series. 2016 Aug ]
- National Toxicology Program. Toxicology studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Feb [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Feb ]
- National Toxicology Program. Toxicity studies of 5-amino-o-cresol administered dermally to F344/NTac rats and B6C3F1/N mice. Toxicity report series. 2015 Nov [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of 5-amino-o-cresol administered dermally to F344/NTac rats and B6C3F1/N mice. Toxicity report series. 2015 Nov ]
- National Toxicology Program. Toxicology and carcinogenesis studies of glycidamide in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies). National Toxicology Program technical report series. 2014 Nov [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies of glycidamide in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies). National Toxicology Program technical report series. 2014 Nov ]