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Systems Toxicology Branch

Rachel Frawley
Rachel Frawley
Health Scientist
Tel 984-287-3132
[email protected]
P.O. Box 12233
Mail Drop K2-15
Durham, NC 27709

Rachel Frawley is a health scientist in the NIEHS Division of Translational Toxicology (DTT) in the Systems Toxicology Branch. In her current role, Rachel provides scientific support to the DTT via leadership and collaboration in the design, planning, evaluation, and reporting of toxicological research studies, with a special interest in algal toxins and immunotoxicants. In addition, Rachel coordinates the monthly DTT Science Forum, which is a venue for presentation and discussion of research and current topics that are of broad interest to the program, and the annual DTT Poster Showcase. She is actively involved in the development and DEIAC initiatives of the DTT.

Prior to joining the DTT, Rachel spent 20+ years as a research scientist in the Division of Intramural Research program at NIEHS. Rachel received a B.S. in biology from Christian Brothers College in Memphis, TN, and an M.S. in microbiology from Clemson, University in Clemson, SC.

Publications

  1. Johnson VJ, Rider CV, Luster MI, Brix A, Burleson GR, Cora M, Elmore SA, Frawley RP, Lopez FR, Mutlu E, Shockley KR, Pierfelice J, Burback B, Co CA, Germolec DR. 2023. Immunotoxicity of N-butylbenzenesulfonamide: impacts on immune function in adult mice and developmentally exposed rats. Toxicol Sci. 196(1):71-84. doi: 10.1093/toxsci/kfad083. PMID: 37584675; PMCID: PMC10613960. [Abstract]
  2. Frawley R, Johnson VJ, Burleson GR, Shockley KR, Cesta MF, Travlos G, Cora M, Roberts G, Germolec D. 2023. Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28-day study. J Appl Toxicol. 43(11):1686-1701. doi: 10.1002/jat.4508. Epub 2023 Jul 5. PMID: 37403832. [Abstract]
  3. National Toxicology Program. 2022. Toxicity studies of select ionic liquids (1-ethyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, 1-butyl-1-methylpyrrolidinium chloride, and n-butylpyridinium chloride) administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxic Rep Ser. (103):NTP-TOX-103. doi: 10.22427/NTP-TOX-103. PMID: 35652689; PMCID: PMC9638888. [Abstract]
  4. Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. 2022. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 42(3):392-408. doi: 10.1002/jat.4224. Epub 2021 Aug 28. PMID: 34453447. [Abstract]
  5. National Toxicology Program. 2020. Toxicity studies of a gum guggul extract formulation administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxic Rep Ser. (99):NTP-TOX-99. doi: 10.22427/NTP-TOX-99. PMID: 33534783; PMCID: PMC8039874. [Abstract]
  6. Frawley RP, Witt KL, Cunny H, Germolec DR, Jackson-Humbles D, Malarkey D, Shockley KR, Stout M, Travlos G, Buccellato M, Fallacara D, Harris S, Kissling GE, Manheng W, Surh II, White K Jr, Auerbach SS. 2020. Evaluation of 2-methoxy-4-nitroaniline (MNA) in hypersensitivity, 14-day subacute, reproductive, and genotoxicity studies. Toxicology. 441:152474. doi: 10.1016/j.tox.2020.152474. Epub 2020 May 5. PMID: 32380031; PMCID: PMC7717523. [Abstract]
  7. Germolec DR, Shipkowski KA, Frawley RP, Evans E. 2018. Markers of Inflammation. Methods Mol Biol. 1803:57-79. doi: 10.1007/978-1-4939-8549-4_5. PMID: 29882133. [Abstract]
  8. Frawley RP, Smith M, Cesta MF, Hayes-Bouknight S, Blystone C, Kissling GE, Harris S, Germolec D. 2018. Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague-Dawley rats and B6C3F1/N mice when administered by oral gavage for 28 days. J Immunotoxicol. 15(1):41-52. doi: 10.1080/1547691X.2018.1445145. PMID: 29514525. [Abstract]
  9. Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR. 2016. Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water. J Immunotoxicol. 13(5):666-75. doi: 10.3109/1547691X.2016.1154118. Epub 2016 May 25. PMID: 27223060; PMCID: PMC5963274. [Abstract]
  10. Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. 2014. Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. Toxicol Sci. 139(2):488-500. doi: 10.1093/toxsci/kfu041. Epub 2014 Apr 8. PMID: 24713691; PMCID: PMC4031622. [Abstract]
  11. Smith MJ, Germolec DR, Frawley RP, White KL Jr. 2013. Immunomodulatory effects of black cohosh (Actaea racemosa) extract in female B6C3F1/N mice. Toxicology. 308:146-57. doi: 10.1016/j.tox.2013.03.017. Epub 2013 Apr 6. PMID: 23571075; PMCID: PMC3684955. [Abstract]
  12. Frawley R, White K Jr, Brown R, Musgrove D, Walker N, Germolec D. 2011. Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive chemicals. Environ Health Perspect. 119(3):371-6. doi: 10.1289/ehp.1002358. Epub 2010 Nov 1. PMID: 21041162; PMCID: PMC3060001. [Abstract]
  13. Germolec DR, Frawley RP, Evans E. 2010. Markers of inflammation. Methods Mol Biol. 598:53-73. doi: 10.1007/978-1-60761-401-2_5. PMID: 19967506. [Abstract]