
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
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Wei Qu, M.D., Ph.D., M.S.
Senior Biologist -
Tel 984-287-4172
[email protected] -
P.O. Box 12233Mail Drop E1-07Durham, NC 27709
Wei Qu, M.D., Ph.D., M.S., is a Senior Biologist with the Mechanistic Toxicology Branch (MTB), Division of Translational Toxicology (DTT) of the National Institute of Environmental Health Sciences (NIEHS). She received an M.D. in Medicine and Public Health and an M.S. in Environmental Toxicology and Epidemiology from Tongji Medical University in 1982 and 1986. She also received a Ph.D. from University of North Carolina in 1996 and finished postdoctoral training at the NIEHS from 1996-1999. She joined the Inorganic Carcinogenesis Section of the National Cancer Institute on detail to the NIEHS in 1999 where she studied the mechanisms of metal-induced toxicity and cancer. In 2010 she joined the National Toxicology Program (NTP) and has worked primarily on metals carcinogenesis, with a strong emphasis on arsenic, cadmium, and lead. Since NTP was changed to DTT, she has participated in Tox21 studies and established an in vitro model for evaluating Perfluorooctanoic acid (PFOA) and Polyfluoroalkyl substances (PFAS) metabolism, accumulation, toxicokinetic, cell painting and healthy response mechanisms. Wei Qu, M.D., Ph.D., M.S., has been a member of Society of Toxicology over 20 years and has actively participated in the SOT annual meeting since 1994. She has served on the SOT Metal Specialty Section Program advisory committee and has served as a reviewer on numerous scientific journals.
Selected Publications
- Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol. 2009 Aug 1;238(3):209-14. doi: 10.1016/j.taap.2009.01.029. Epub 2009 Feb 21. PMID: 19236887; PMCID: PMC4287357. [Abstract]
- Zhan L, Zhang H, Zhang Q, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J. Corrigendum to "Regulatory role of KEAP1 and NRF2 in PPARg expression and chemoresistance in human non-small-cell lung carcinoma cells" [Free Radic Biol Med. 53 (2012) 758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7. PMID: 22684020]. Free Radic Biol Med. 2022 Feb 1;179:418-419. doi: 10.1016/j.freeradbiomed.2021.11.014. Epub 2021 Nov 30. Erratum for: Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. PMID: 34857443. [Abstract]
- Gwinn WM, Qu W, Shines CJ, Bousquet RW, Taylor GJ, Waalkes MP, Morgan DL. Macrophage solubilization and cytotoxicity of indium-containing particles in vitro. Toxicol Sci. 2013 Oct;135(2):414-24. doi: 10.1093/toxsci/kft154. Epub 2013 Jul 19. PMID: 23872580; PMCID: PMC3807620. [Abstract]
- Qu W, Crizer DM, DeVito MJ, Waidyanatha S, Xia M, Houck K, Ferguson SS. Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening. Toxicol In Vitro. 2021 Jun;73:105109. doi: 10.1016/j.tiv.2021.105109. Epub 2021 Feb 18. PMID: 33609632; PMCID: PMC10838150. [Abstract]
- Whiteside TE, Qu W, DeVito MJ, Brar SS, Bradham KD, Nelson CM, Travlos GS, Kissling GE, Kurtz DM. Elevated Arsenic and Lead Concentrations in Natural Healing Clay Applied Topically as a Treatment for Ulcerative Dermatitis in Mice. J Am Assoc Lab Anim Sci. 2020 Mar 1;59(2):212-220. doi: 10.30802/AALAS-JAALAS-19-000068. Epub 2020 Feb 14. PMID: 32059757; PMCID: PMC7073401. [Abstract]
- Scarborough PE, Ma J, Qu W, Zeldin DC. P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues. Drug Metab Rev. 1999 Feb;31(1):205-34. doi: 10.1081/dmr-100101915. PMID: 10065373. [Abstract]
- Qu W and Xia S. Induction of SCE in human lymphocytes by Tetrachlorovinphos with and without metabolic activation. J.: J. of Tongji Medical University 2: 144-147, 1988.
- Gwinn WM, Qu W, Bousquet RW, Price H, Shines CJ, Taylor GJ, Waalkes MP, Morgan DL. Macrophage solubilization and cytotoxicity of indium-containing particles as in vitro correlates to pulmonary toxicity in vivo. Toxicol Sci. 2015 Mar;144(1):17-26. doi: 10.1093/toxsci/kfu273. Epub 2014 Dec 19. PMID: 25527823; PMCID: PMC4349143. [Abstract]
- Qu W, Yan Y, Gerrish K, Scappini E, Tucker CJ, Dixon D, Merrick BA. Chronic PFOA exposure in vitro causes acquisition of multiple tumor cell characteristics in rat liver cells. Toxicol In Vitro. 2023 Jun;89:105577. doi: 10.1016/j.tiv.2023.105577. Epub 2023 Feb 26. PMID: 36849026; PMCID: PMC10427995. [Abstract]
- Qu W, Waalkes MP. Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure. Toxicol Appl Pharmacol. 2015 Feb 1;282(3):267-74. doi: 10.1016/j.taap.2014.11.014. Epub 2014 Dec 5. PMID: 25485709; PMCID: PMC4315697. [Abstract]
- Qu W, Diwan BA, Reece JM, Bortner CD, Pi J, Liu J, Waalkes MP. Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress. Int J Cancer. 2005 Apr 10;114(3):346-55. doi: 10.1002/ijc.20736. PMID: 15551354. [Abstract]
- Pi J, Bai Y, Reece JM, Williams J, Liu D, Freeman ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP. Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic Biol Med. 2007 Jun 15;42(12):1797-806. doi: 10.1016/j.freeradbiomed.2007.03.001. Epub 2007 Mar 12. PMID: 17512459; PMCID: PMC1950666. [Abstract]
- Liu J, Kadiiska MB, Liu Y, Lu T, Qu W, Waalkes MP. Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol Sci. 2001 Jun;61(2):314-20. doi: 10.1093/toxsci/61.2.314. PMID: 11353140. [Abstract]
- Qu W, Rippe RA, Ma J, Scarborough P, Biagini C, Fiedorek FT, Travlos GS, Parker C, Zeldin DC. Nutritional status modulates rat liver cytochrome P450 arachidonic acid metabolism. Mol Pharmacol. 1998 Sep;54(3):504-13. doi: 10.1124/mol.54.3.504. PMID: 9730909. [Abstract]
- Qu W, Pi J, Waalkes MP. Metallothionein blocks oxidative DNA damage in vitro. Arch Toxicol. 2013 Feb;87(2):311-21. doi: 10.1007/s00204-012-0927-y. Epub 2012 Aug 23. PMID: 22914987; PMCID: PMC3554841. [Abstract]
- Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med. 2008 Sep 1;45(5):651-8. doi: 10.1016/j.freeradbiomed.2008.05.020. Epub 2008 Jun 3. PMID: 18572023; PMCID: PMC2658531. [Abstract]
- Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Masinde TA, Qu W, Clayton NP, Morrison JP, Tomer KB, Zeldin DC. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. Drug Metab Dispos. 2013 Apr;41(4):763-73. doi: 10.1124/dmd.112.049429. Epub 2013 Jan 11. PMID: 23315644; PMCID: PMC3608456. [Abstract]
- Zuo P, Qu W, Cooper RN, Goyer RA, Diwan BA, Waalkes MP. Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation. Toxicol Sci. 2009 Sep;111(1):100-8. doi: 10.1093/toxsci/kfp132. Epub 2009 Jun 19. PMID: 19542206; PMCID: PMC2726298. [Abstract]
- Sakurai T, Qu W, Sakurai MH, Waalkes MP. A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. Chem Res Toxicol. 2002 May;15(5):629-37. doi: 10.1021/tx0101604. PMID: 12018983. [Abstract]
- Liu J, Kadiiska MB, Corton JC, Qu W, Waalkes MP, Mason RP, Liu Y, Klaassen CD. Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radic Biol Med. 2002 Mar 15;32(6):525-35. doi: 10.1016/s0891-5849(01)00826-7. PMID: 11958953. [Abstract]
- Qu W, Liu J, Dill AL, Saavedra JE, Keefer LK, Waalkes MP. V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity. Cancer Sci. 2009 Mar;100(3):382-8. doi: 10.1111/j.1349-7006.2008.01050.x. Epub 2008 Dec 15. PMID: 19154403; PMCID: PMC2678544. [Abstract]
- Qu W, Tokar EJ, Kim AJ, Bell MW, Waalkes MP. Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells. Environ Health Perspect. 2012 Sep;120(9):1265-71. doi: 10.1289/ehp.1205082. Epub 2012 May 24. PMID: 22626610; PMCID: PMC3440134. [Abstract]
- Ma J, Graves J, Bradbury JA, Zhao Y, Swope DL, King L, Qu W, Clark J, Myers P, Walker V, Lindzey J, Korach KS, Zeldin DC. Regulation of mouse renal CYP2J5 expression by sex hormones. Mol Pharmacol. 2004 Mar;65(3):730-43. doi: 10.1124/mol.65.3.730. PMID: 14978252. [Abstract]
- Qu W, Cheng L, Dill AL, Saavedra JE, Hong SY, Keefer LK, Waalkes MP. Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1. Chem Biol Interact. 2011 Aug 15;193(1):88-96. doi: 10.1016/j.cbi.2011.05.005. Epub 2011 May 20. PMID: 21621526; PMCID: PMC3155876. [Abstract]
- Ma J, Qu W, Scarborough PE, Tomer KB, Moomaw CR, Maronpot R, Davis LS, Breyer MD, Zeldin DC. Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney. J Biol Chem. 1999 Jun 18;274(25):17777-88. doi: 10.1074/jbc.274.25.17777. PMID: 10364221. [Abstract]
- Liu J, Li C, Qu W, Leslie E, Bonifant CL, Buzard GS, Saavedra JE, Keefer LK, Waalkes MP. Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation. Mol Cancer Ther. 2004 Jun;3(6):709-14. PMID: 15210857. [Abstract]
- Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Exp Cell Res. 2003 Nov 1;290(2):234-45. doi: 10.1016/s0014-4827(03)00341-0. PMID: 14567983. [Abstract]
- Takiguchi M, Achanzar WE, Qu W, Li G, Waalkes MP. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp Cell Res. 2003 Jun 10;286(2):355-65. doi: 10.1016/s0014-4827(03)00062-4. PMID: 12749863. [Abstract]
- Liu J, Malavya S, Wang X, Saavedra JE, Keefer LK, Tokar E, Qu W, Waalkes MP, Shami PJ. Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells. Genomics. 2009 Jul;94(1):32-8. doi: 10.1016/j.ygeno.2009.03.005. Epub 2009 Apr 5. PMID: 19348908; PMCID: PMC3496159. [Abstract]
- Qu W, Ke H, Pi J, Broderick D, French JE, Webber MM, Waalkes MP. Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway. Environ Health Perspect. 2007 Jul;115(7):1094-100. doi: 10.1289/ehp.10075. PMID: 17637928; PMCID: PMC1913575. [Abstract]
- Liu J, Benbrahim-Tallaa L, Qian X, Yu L, Xie Y, Boos J, Qu W, Waalkes MP. Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells. Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15. doi: 10.1016/j.taap.2006.06.006. Epub 2006 Jun 20. PMID: 16876216. [Abstract]
- Qu W, Kasprzak KS, Kadiiska M, Liu J, Chen H, Maciag A, Mason RP, Waalkes MP. Mechanisms of arsenic-induced cross-tolerance to nickel cytotoxicity, genotoxicity, and apoptosis in rat liver epithelial cells. Toxicol Sci. 2001 Oct;63(2):189-95. doi: 10.1093/toxsci/63.2.189. PMID: 11568362. [Abstract]
- Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC. Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. J Biol Chem. 2001 Jul 6;276(27):25467-79. doi: 10.1074/jbc.M100545200. Epub 2001 Apr 27. PMID: 11328810. [Abstract]
- Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP. Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis. Int J Cancer. 2005 Aug 10;116(1):20-6. doi: 10.1002/ijc.20990. PMID: 15756686. [Abstract]
- Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D. Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. Arch Toxicol. 2014 Aug;88(8):1619-29. doi: 10.1007/s00204-014-1305-8. Epub 2014 Jul 9. PMID: 25005685; PMCID: PMC4130362. [Abstract]
- Shimoda R, Achanzar WE, Qu W, Nagamine T, Takagi H, Mori M, Waalkes MP. Metallothionein is a potential negative regulator of apoptosis. Toxicol Sci. 2003 Jun;73(2):294-300. doi: 10.1093/toxsci/kfg095. Epub 2003 Apr 15. PMID: 12700406. [Abstract]
- Tokar EJ, Qu W, Waalkes MP. Arsenic, stem cells, and the developmental basis of adult cancer. Toxicol Sci. 2011 Mar;120 Suppl 1(Suppl 1):S192-203. doi: 10.1093/toxsci/kfq342. Epub 2010 Nov 11. PMID: 21071725; PMCID: PMC3043086. [Abstract]
- Qu W, Fuquay R, Sakurai T, Waalkes MP. Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression. Mol Carcinog. 2006 Aug;45(8):561-71. doi: 10.1002/mc.20185. PMID: 16568437. [Abstract]
- Qu W, Ikejima K, Zhong Z, Waalkes MP, Thurman RG. Glycine blocks the increase in intracellular free Ca2+ due to vasoactive mediators in hepatic parenchymal cells. Am J Physiol Gastrointest Liver Physiol. 2002 Dec;283(6):G1249-56. doi: 10.1152/ajpgi.00197.2002. Epub 2002 Aug 14. PMID: 12388211. [Abstract]
- Qu W, Bortner CD, Sakurai T, Hobson MJ, Waalkes MP. Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway. Carcinogenesis. 2002 Jan;23(1):151-9. doi: 10.1093/carcin/23.1.151. PMID: 11756236. [Abstract]
- Brambila EM, Achanzar WE, Qu W, Webber MM, Waalkes MP. Chronic arsenic-exposed human prostate epithelial cells exhibit stable arsenic tolerance: mechanistic implications of altered cellular glutathione and glutathione S-transferase. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):99-107. PMID: 12387749. [Abstract]
- Qu W, Diwan BA, Liu J, Goyer RA, Dawson T, Horton JL, Cherian MG, Waalkes MP. The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am J Pathol. 2002 Mar;160(3):1047-56. doi: 10.1016/S0002-9440(10)64925-5. PMID: 11891201; PMCID: PMC1867192. [Abstract]
- Qu W, Liu J, Fuquay R, Saavedra JE, Keefer LK, Waalkes MP. The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis. Cancer Lett. 2007 Oct 28;256(2):238-45. doi: 10.1016/j.canlet.2007.06.009. Epub 2007 Jul 20. PMID: 17658681; PMCID: PMC2093999. [Abstract]
- Orihuela R, Kojima C, Tokar EJ, Person RJ, Xu Y, Qu W, Waalkes MP. Oxidative DNA damage after acute exposure to arsenite and monomethylarsonous acid in biomethylation-deficient human cells. Toxicol Mech Methods. 2013 Jul;23(6):389-95. doi: 10.3109/15376516.2012.762570. Epub 2013 Feb 6. PMID: 23301828. [Abstract]
- Qu W, Liu J, Fuquay R, Shimoda R, Sakurai T, Saavedra JE, Keefer LK, Waalkes MP. The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level. Nitric Oxide. 2005 Mar;12(2):114-20. doi: 10.1016/j.niox.2005.01.005. PMID: 15740985. [Abstract]
- Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D. Response to letter to the editor by Cohen et al. (2014) "Re: Waalkes et al.: Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014". Arch Toxicol. 2014 Nov;88(11):2063-5. doi: 10.1007/s00204-014-1369-5. Epub 2014 Sep 25. PMID: 25253650; PMCID: PMC4237168. [Abstract]
- Tokar EJ, Person RJ, Ngalame NN, Qu W, Waalkes, MP. Oxidative Stress and the Inorganic Carcinogens, Chapter 16; In Kehrer, Roberts, Klotz (Eds): Oxidative Stress in Applied Basic Research and Clinical Practice, Springer. Humana Press, pp. 323-334, 2015.
- Tokar EJ, Qu W, Liu J, Liu W, Webber MM, Phang JM, Waalkes MP. Arsenic-specific stem cell selection during malignant transformation. J Natl Cancer Inst. 2010 May 5;102(9):638-49. doi: 10.1093/jnci/djq093. Epub 2010 Mar 25. PMID: 20339138; PMCID: PMC2864291. [Abstract]
- Li B, Cui W, Tan Y, Luo P, Chen Q, Zhang C, Qu W, Miao L, Cai L. Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition. J Cell Mol Med. 2014 May;18(5):895-906. doi: 10.1111/jcmm.12239. Epub 2014 Mar 6. PMID: 24597671; PMCID: PMC4119395. [Abstract]
- Coppin JF, Qu W, Waalkes MP. Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J Biol Chem. 2008 Jul 11;283(28):19342-50. doi: 10.1074/jbc.M802942200. Epub 2008 May 16. PMID: 18487201; PMCID: PMC2443667. [Abstract]
- Kojima C, Qu W, Waalkes MP, Himeno S, Sakurai T. Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Toxicol Sci. 2006 May;91(1):70-81. doi: 10.1093/toxsci/kfj117. Epub 2006 Jan 25. PMID: 16436460. [Abstract]
- Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Himeno S, Fujiwara K. Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality. Toxicol Appl Pharmacol. 2005 Aug 1;206(1):54-65. doi: 10.1016/j.taap.2004.11.008. Epub 2004 Dec 28. PMID: 15963344. [Abstract]
- Wang AG, Xia T, Yuan J, Yu RA, Yang KD, Chen XM, Qu W, Waalkes MP. Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro. Food Chem Toxicol. 2004 Oct;42(10):1647-53. doi: 10.1016/j.fct.2004.05.010. PMID: 15304311. [Abstract]
- Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Fujiwara K. Role of glutathione in dimethylarsinic acid-induced apoptosis. Toxicol Appl Pharmacol. 2004 Aug 1;198(3):354-65. doi: 10.1016/j.taap.2003.10.015. PMID: 15276415. [Abstract]
- Liu J, Qu W, Saavedra JE, Waalkes MP. The nitric oxide donor, O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), protects against cadmium-induced hepatotoxicity in mice. J Pharmacol Exp Ther. 2004 Jul;310(1):18-24. doi: 10.1124/jpet.103.065003. Epub 2004 Mar 9. PMID: 15010501. [Abstract]
- Kojima C, Sakurai T, Ochiai M, Kumata H, Qu W, Waalkes MP, and Fujiwara K. Cytotoxicological aspects of an organic arsenic compound in marine animals, arsenobetaine. Appl. 2002. Organometallic Chem. 16: 421-426.
- Qu W, Tokar EJ, Kim AJ, Bell MW, Waalkes MP. A window of early detect pancreatic cancer: The evidence of cancer stem cell development after chronic exposure of cadmium chloride. Environ Health Perspect. 2013. Chinese Edition, 121:23.
- Oleksiak MF, Wu S, Parker C, Qu W, Cox R, Zeldin DC, Stegeman JJ. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch Biochem Biophys. 2003 Mar 15;411(2):223-34. doi: 10.1016/s0003-9861(02)00734-8. PMID: 12623071. [Abstract]
- Moran JH, Mitchell LA, Bradbury JA, Qu W, Zeldin DC, Schnellmann RG, Grant DF. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):268-79. doi: 10.1006/taap.2000.9053. Erratum in: Toxicol Appl Pharmacol. 2001 Mar 15;171(3):196. PMID: 11042099. [Abstract]
- Gavett SH, Madison SL, Chulada PC, Scarborough PE, Qu W, Boyle JE, Tiano HF, Lee CA, Langenbach R, Roggli VL, Zeldin DC. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J Clin Invest. 1999 Sep;104(6):721-32. doi: 10.1172/JCI6890. PMID: 10491407; PMCID: PMC408432. [Abstract]
- Qu W, Graves LM, Thurman RG. PGE(2) stimulates O(2) uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase. Am J Physiol. 1999 Nov;277(5):G1048-54. doi: 10.1152/ajpgi.1999.277.5.G1048. PMID: 10564111. [Abstract]
- Qu W, Zhong Z, Arteel GE, Thurman RG. Stimulation of oxygen uptake by prostaglandin E2 is oxygen dependent in perfused rat liver. Am J Physiol. 1998 Sep;275(3):G542-9. doi: 10.1152/ajpgi.1998.275.3.G542. PMID: 9724267. [Abstract]
- Ikejima K, Qu W, Stachlewitz RF, Thurman RG. Kupffer cells contain a glycine-gated chloride channel. Am J Physiol. 1997 Jun;272(6 Pt 1):G1581-6. doi: 10.1152/ajpgi.1997.272.6.G1581. PMID: 9227496. [Abstract]
- Zhong Z, Connor H, Mason RP, Qu W, Stachlewitz RF, Gao W, Lemasters JJ, Thurman RG. Destruction of Kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol-treated rats. Liver Transpl Surg. 1996 Sep;2(5):383-7. doi: 10.1002/lt.500020509. PMID: 9346680. [Abstract]
- Ikejima K, Qu W, Stachlewitz RF, and Thurman RG. Glycine prevents elevation of intracellular Ca2+ in Kupffer cells by endotoxin (LPS) via actions on a chloride channel. 1997. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G1581-G1586.
- Qu W, Zhong Z, Goto M, Thurman RG. Kupffer cell prostaglandin E2 stimulates parenchymal cell O2 consumption: alcohol and cell-cell communication. Am J Physiol. 1996 Apr;270(4 Pt 1):G574-80. doi: 10.1152/ajpgi.1996.270.4.G574. PMID: 8928786. [Abstract]
- Decker K, Gerok W, eds. Kluwer Academic Press, Lancaster UK, Thurman RG, Savier E, Adachi Y, Shedlofsky SI, Lemasters JJ, Gao W, Bradford BU, Zhong Z, Knecht KT, Qu W, Currin RT, Lichtmman S, Wang J, and Goto M. Cytokines in Liver Transplantation and Alcoholic Liver Disease. 1995. In: Cytokines and the Liver. Decker, K. and Gerok, W. eds. Kluwer Academic Press, Lancaster, UK.
- Zhong Z, Connor HD, Mason RP, Qu W, Gao W, Lemasters JJ, Thurman RG. Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats. J Pharmacol Exp Ther. 1995 Dec;275(3):1512-7. PMID: 8531123. [Abstract]
- Zhong Z, Qu W, Connor HD, Thurman RG. Inactivation of Kupffer cells minimizes reperfusion injury in fat-loaded livers from ethanol-treated rats. Transplant Proc. 1995 Feb;27(1):528-30. PMID: 7879088. [Abstract]
- Qu W, Kauffman FC, Thurman RG. Food restriction stimulates conjugation of p-nitrophenol in perfused rat liver. Arch Biochem Biophys. 1995 Jun 1;319(2):451-6. doi: 10.1006/abbi.1995.1316. PMID: 7786027. [Abstract]
- Nakagawa Y, Matsumura T, Goto M, Qu W, Kauffman FC, Thurman RG. Increase in oxygen uptake due to arachidonic acid is oxygen dependent in the perfused liver. Am J Physiol. 1994 May;266(5 Pt 1):G953-9. doi: 10.1152/ajpgi.1994.266.5.G953. PMID: 8203541. [Abstract]
- Qu W, Kauffman FC, Thurman RG. Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver. Biochem Pharmacol. 1994 Jul 19;48(2):311-7. doi: 10.1016/0006-2952(94)90102-3. PMID: 8053926. [Abstract]
- Qu W, Savier E, and Thurman RG. Kupffer cells activated by transplantation enhance drug metabolism. Kupffer Cell Foundation. 4: 368-370, 1993.
- Qu W, Savier E, Thurman RG. Stimulation of monooxygenation and conjugation after liver transplantation in the rat: involvement of Kupffer cells. Mol Pharmacol. 1992 Jun;41(6):1149-54. PMID: 1614413. [Abstract]
- Wall KL, Gao W, Qu W, Kwei G, Kauffman FC, Thurman RG. Food restriction increases detoxification of polycyclic aromatic hydrocarbons in the rat. Carcinogenesis. 1992 Apr;13(4):519-23. doi: 10.1093/carcin/13.4.519. PMID: 1576702. [Abstract]
- Zhan L, Zhang H, Zhang Q, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J. Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7. Erratum in: Free Radic Biol Med. 2022 Feb 01;179:418-419. doi: 10.1016/j.freeradbiomed.2021.11.014. PMID: 22684020; PMCID: PMC3418425. [Abstract]
- Wu YR, Kauffman FC, Qu W, Ganey P, Thurman RG. Unique role of oxygen in regulation of hepatic monooxygenation and glucuronidation. Mol Pharmacol. 1990 Jul;38(1):128-33. PMID: 2370851. [Abstract]