Skip Navigation
Cell Biology Group
Yan, Z-H., Karam, W.K., Staudinger, J.L., Medvedev, A., Ghanayem, B.I., and Jetten, A.M. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem . 273: 10948-10957 (1998). [Abstract Yan, Z-H., Karam, W.K., Staudinger, J.L., Medvedev, A., Ghanayem, B.I., and Jetten, A.M. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem. 273:10948-10957 (1998). ] Adachi, H., Adams, A., Hughes, F.M., Zhang, J., Cidlowski, J.A., and Jetten, A.M. Induction of apoptosis by the novel retinoid AHPN in human T cell lymphoma cells involves caspase-dependent and independent pathways. Cell Death & Diff . 5: 973-983 (1998) [Abstract Adachi, H., Adams, A., Hughes, F.M., Zhang, J., Cidlowski, J.A., and Jetten, A.M. Induction of apoptosis by the novel retinoid AHPN in human T cell lymphoma cells involves caspase-dependent and independent pathways. Cell Death & Diff. 5: 973-983 (1998) ] Medvedev, A., Chistokhina, A., Matsuura, W., and Jetten, A.M. Regulation of the transglutaminase I gene: identification of DNA elements involved in its transcriptional control in tracheobronchial epithelial cells. J. Biol. Chem . 274: 3887-3896 (1999). [Abstract Medvedev, A., Chistokhina, A., Matsuura, W., and Jetten, A.M. Regulation of the transglutaminase I gene: identification of DNA elements involved in its transcriptional control in tracheobronchial epithelial cells. J. Biol. Chem. 274: 3887-3896 (1999). ] Sakaue, M., Adachi, H., and Jetten, A.M. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis. Mol. Pharmacol . 55: 668-676 (1999). [Abstract Sakaue, M., Adachi, H., and Jetten, A.M. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis. Mol. Pharmacol. 55: 668-676 (1999). ] Matsuura, H., Sakaue, M., Subbaramaiah, K., Kamitani, H., Eling, T., Dannenberg, A.J., Tanabe, T., Inoue, H., Arata, J., and Jetten, A.M. Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem . 274 : 29138-29148 (1999). [Abstract Matsuura, H., Sakaue, M., Subbaramaiah, K., Kamitani, H., Eling, T., Dannenberg, A.J., Tanabe, T., Inoue, H., Arata, J., and Jetten, A.M. Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 274: 29138-29148 (1999). ] Jetten, A.M., and Suter U. The peripheral myelin protein 22 and epithelial membrane protein family. Structure, function, regulation and roles in disease. Progress in Nucl. Acids Res. and Mol. Biol . 64: 97-129 (2000) [Abstract Jetten, A.M., and Suter U. The peripheral myelin protein 22 and epithelial membrane protein family. Structure, function, regulation and roles in disease. Progress in Nucl. Acids Res. and Mol. Biol. 64: 97-129 (2000) ] Kurebayashi, S., Ueda, E., Sakaue, M., Patel, D., Medvedev, A., Zhang, F., and Jetten, A.M. Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci USA . 97: 10132- 10137 (2000) [Abstract Kurebayashi, S., Ueda, E., Sakaue, M., Patel, D., Medvedev, A., Zhang, F., and Jetten, A.M. Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci USA. 97: 10132- 10137 (2000) ] Kim, S.Y., Adachi, H., Koo, J.S., and Jetten, A.M. Induction of cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells. Mol. Pharm . 58: 483-490 (2000) [Abstract Kim, S.Y., Adachi, H., Koo, J.S., and Jetten, A.M. Induction of cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells. Mol. Pharm. 58: 483-490 (2000) ] Yan, Z., and Jetten, A.M. Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. J. Biol. Chem . 275: 35077-35085 (2000) [Abstract Yan, Z., and Jetten, A.M. Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. J. Biol. Chem. 275: 35077-35085 (2000) ] Jetten, A.M., Kurebayashi, S., Ueda, E., and Sakaue, M. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Progress in Nucl. Acids Res. and Mol. Biol . 69: 205-247 (2001) [Abstract Jetten, A.M., Kurebayashi, S., Ueda, E., and Sakaue, M. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Progress in Nucl. Acids Res. and Mol. Biol. 69: 205-247 (2001) ] Sakaue, M., Adachi, H., Dawson, M., and Jetten, A.M. Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2. Cell Death & Diff . 8: 411-424 (2001) [Abstract Sakaue, M., Adachi, H., Dawson, M., and Jetten, A.M. Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2. Cell Death & Diff. 8: 411-424 (2001) ] Zhang, F., Nakanishi, G., Kurebayashi, S., Yoshino, K., Perantoni, A., Kim, Y-S., and Jetten A.M. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. Identification of transactivation and repressor functions. J. Biol. Chem. 277: 10139-10149 (2002). [Abstract Zhang, F., Nakanishi, G., Kurebayashi, S., Yoshino, K., Perantoni, A., Kim, Y-S., and Jetten A.M. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. Identification of transactivation and repressor functions. J. Biol. Chem. 277: 10139-10149 (2002). ] Ueda, E., Kurebayashi, S., Sakaue, M., Backlund, M., Koller, B., and Jetten, A.M. High incidence of T cell lymphomas in mice deficient in the retinoid-related orphan receptor RORg. Cancer Res . 62: 901-909 (2002). [Abstract Ueda, E., Kurebayashi, S., Sakaue, M., Backlund, M., Koller, B., and Jetten, A.M. High incidence of T cell lymphomas in mice deficient in the retinoid-related orphan receptor RORg. Cancer Res. 62: 901-909 (2002). ] Kim, Y-S., Lewandoski, M., Perantoni, A., Kurebayashi, S., and Jetten, A.M. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. J. Biol. Chem. 277: 30901-30913 (2002). [Abstract Kim, Y-S., Lewandoski, M., Perantoni, A., Kurebayashi, S., and Jetten, A.M. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. J. Biol. Chem. 277: 30901-30913 (2002). ] Yan, Z., Kim, Y-S., and Jetten, A.M. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem . 277: 32379-32388 (2002). [Abstract Yan, Z., Kim, Y-S., and Jetten, A.M. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem. 277: 32379-32388 (2002). ] Jetten, A.M., and Ueda, E. Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation, and disease. Cell Death & Diff . 9 :1167-1171 (2002). [Abstract Jetten, A.M., and Ueda, E. Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation, and disease. Cell Death & Diff. 9:1167-1171 (2002). ] Newman, D., Sakaue, M., Koo, J.S., Baek, S.J., Eling, T., and Jetten, A.M. Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharm. 63 :557-564 (2003). [Abstract Newman, D., Sakaue, M., Koo, J.S., Baek, S.J., Eling, T., and Jetten, A.M. Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharm. 63:557-564 (2003). ] Yang, G., Zhang, Y-L., Buchhold, G.M., Jetten, A.M., and O’Brien, D.A. Free Full Text Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis. Biol. Reprod. 68 :1620-1630 (2003). [Abstract Yang, G., Zhang, Y-L., Buchhold, G.M., Jetten, A.M., and O’Brien, D.A. Free Full Text Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis. Biol. Reprod. 68:1620-1630 (2003). ] Lewandoski, M., and Jetten, A.M. GLIS3, a novel member of the GLIS subfamily of Krüppel-like Zinc Finger Proteins with Repressor and Activation Functions. Nucl. Acids Res . 31 : 5513-5525 (2003) [Abstract Lewandoski, M., and Jetten, A.M. GLIS3, a novel member of the GLIS subfamily of Krüppel-like Zinc Finger Proteins with Repressor and Activation Functions. Nucl. Acids Res. 31: 5513-5525 (2003) ] Daniely, Y., Liao, G., Dixon, D., Linnoila, R.I., Lori, A., Randell, S.H., Oren, M., and Jetten, A.M. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol . 287 :C171-C181 (2004). [Abstract Daniely, Y., Liao, G., Dixon, D., Linnoila, R.I., Lori, A., Randell, S.H., Oren, M., and Jetten, A.M. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol. 287:C171-C181 (2004). ] Nakajima, T., Fujino, S., Nakanishi, G., Kim, Y-S., and Jetten, A.M. TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nucl. Acids Res . 32 :4194-4204 (2004). [Abstract Nakajima, T., Fujino, S., Nakanishi, G., Kim, Y-S., and Jetten, A.M. TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nucl. Acids Res. 32:4194-4204 (2004). ] Kim, Y-S., Nakanishi, G., Oudes, A.J., Kim, K.H., Wang, H., Kilpatrick, D.L., and Jetten, A.M. TSP57 : a novel gene induced during a specific stage of spermatogenesis. Biol. Reprod . 70 :106-113 (2004). [Abstract Kim, Y-S., Nakanishi, G., Oudes, A.J., Kim, K.H., Wang, H., Kilpatrick, D.L., and Jetten, A.M. TSP57: a novel gene induced during a specific stage of spermatogenesis. Biol. Reprod. 70:106-113 (2004). ] Jetten, A.M. Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs). Current Drug Targets-Inflammation & Allergy 3 :395-412 (2004). [Abstract Jetten, A.M. Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs). Current Drug Targets-Inflammation & Allergy 3:395-412 (2004). ] Stapleton, C., Jaradat, M., Dixon, D., Kang, H.S., Kim, S-C., Liao, G., Carey, M.A., Cristiano, J., Moorman, M.P., and Jetten, A.M. Enhanced susceptibility of staggerer (RORasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am. J. Physiol . Lung Cell. Mol. Physiol. 289 :L144-L152 (2005). [Abstract Stapleton, C., Jaradat, M., Dixon, D., Kang, H.S., Kim, S-C., Liao, G., Carey, M.A., Cristiano, J., Moorman, M.P., and Jetten, A.M. Enhanced susceptibility of staggerer (RORasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L144-L152 (2005). ] Kim, S-C., Kim, Y-S., and Jetten, A.M. Nucl. Acids Res . 33 :6805-6815 (2005). [Abstract Kim, S-C., Kim, Y-S., and Jetten, A.M. Nucl. Acids Res. 33:6805-6815 (2005). ] Nakanishi, G., Kim, Y-S., Nakajima, T., and Jetten, A.M. J. Invest. Dermatol . 126 :49-60 (2006) [Abstract Nakanishi, G., Kim, Y-S., Nakajima, T., and Jetten, A.M. J. Invest. Dermatol. 126:49-60 (2006) ] Kang, H-S., Beak, J.Y., Kim, Y-S., and Jetten, A.M. NABP1, a novel RORg-regulated gene encoding a single-stranded nucleic acid binding protein. Biochem. J. 397 :89-99 (2006) [Abstract Kang, H-S., Beak, J.Y., Kim, Y-S., and Jetten, A.M. NABP1, a novel RORg-regulated gene encoding a single-stranded nucleic acid binding protein. Biochem. J. 397:89-99 (2006) ] Jetten, A.M., and Joo, J.H. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv. Develop. Biol . 16 :314-354 (2006) Jaradat, M., Stapleton, C., Tilley, S., Dixon, D., McCaskill, J.M., Kang, H.S., Angers, M, Liao, G., and Jetten, A.M. Modulatory role for retinoid-related orphan receptor a (RORa) in allergen-induced lung inflammation. Am. J. Resp. Crit. Care Med. 174 :1299-309 (2006) [Abstract Jaradat, M., Stapleton, C., Tilley, S., Dixon, D., McCaskill, J.M., Kang, H.S., Angers, M, Liao, G., and Jetten, A.M. Modulatory role for retinoid-related orphan receptor a (RORa) in allergen-induced lung inflammation. Am. J. Resp. Crit. Care Med. 174:1299-309 (2006) ] Jetten A.M., and Joo J.H. Retinoid-related Orphan Receptors (RORs): Roles in cellular differentiation and development. Advances in Developmental Biology 313-355 (2006). [Abstract Jetten A.M., and Joo J.H. Retinoid-related Orphan Receptors (RORs): Roles in cellular differentiation and development. Advances in Developmental Biology 313-355 (2006). ] Tilley, S., Jaradat, M., Stapleton, C., Dixon, D., Kim, S-C., Erikson, C.J., McCaskill, J.M., Liao, G., Koller, B.H., and Jetten, A.M. Reduced Susceptibility to Allergen-induced Airway Inflammation in Mice Deficient in Retinoid-related Orphan Receptor (ROR) g. J. Immunol . 178 :3208-3218 (2007) Lee, S-J., Perara, L., Coulter, S., Mohrenweiser, H.W., Jetten, A.M., and Goldstein, J.A. The discovery of new coding alleles of CYP26A1 which are potentially defective in the metabolism of all-trans retinoic acid metabolism and their assessment in a recombinant cDNA expression system. Pharmacogenet. Genomics . 17 :169-180 (2007) Yan, J., Kim, Y-S., Yang, X-P., Albers, M., Koegl, M., and Jetten, A.M. Ubiquitin interacting motifs of RAP80 are critical in its regulation of Estrogen Receptor a. Nucl. Acids Res . 35 :1673-1686 (2007) Kim, Y-S., Kang, H.S., and Jetten, A.M. The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/b-catenin signaling pathway. FEBS Letters 581 :858-864 (2007) Joo, J.H., Liao, G., Collins, J.B., Grissom, S.F., and Jetten, A.M. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum (ER) stress response. Cancer Res. 67 :7929-7936 (2007) Beak, J.Y., Kang, H.S., Kim, Y-S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. J. Bone Mineral Res. 22 :1234-1244 (2007) Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 :480-483 (2007) Yan, J., Kim, Y-S., Yang, Y-P., Li, L-P., Liao, G., Xia, F., and Jetten, A.M. The UIM-containing protein RAP80 functions in DNA damage repair response. Cancer Res. 67 :6647-6656 (2007) Yan, J., Yang, X-P., Kim, Y-S., Joo, J.H., and Jetten, A.M. RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation. Biochem. Biophys. Res. Comm. 362 :132-128 (2007) Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wada, T, Xie, W., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORa and RORg in Phase I and Phase II metabolism. Physiol. Genomics 31 :281-294 (2007) Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 8 :1234-1244 (2007). [Abstract Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 8:1234-1244 (2007). ] Yan, J., Kim, Y.S., Yang, X-P., Li, L.P., Liao, G., Xia, F., and Jetten, A.M. The UIM-containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Research 14 :6647-6656 (2007). [Abstract Yan, J., Kim, Y.S., Yang, X-P., Li, L.P., Liao, G., Xia, F., and Jetten, A.M. The UIM-containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Research 14:6647-6656 (2007). ] Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 7152 :480-483 (2007). [Abstract Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 7152:480-483 (2007). ] Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wade, T., Xie, W., Collins, J.B., Grissom, S.F., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORa and RORy in Phase I and Phase II metabolism. Physiological Genomics 2 :281-294 (2007). [Abstract Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wade, T., Xie, W., Collins, J.B., Grissom, S.F., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORa and RORy in Phase I and Phase II metabolism. Physiological Genomics 2:281-294 (2007). ] Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic acids research 36 (5):1690-1702 (2008). [Abstract Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic acids research 36(5):1690-1702 (2008). ] Yang, X.O., Pappu, B.P., Nurieva, R., Akimzhanov, A., Kang, H.S., Chung, Y., Ma, L., Shah, B., Panopoulos, A.D., Watowich, S.S., Schluns, K.S., Tian, Q., Jetten, A.M., and Dong, C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR(alpha) and ROR(gamma). Immunity 28 (1):29-39 (2008). [Abstract Yang, X.O., Pappu, B.P., Nurieva, R., Akimzhanov, A., Kang, H.S., Chung, Y., Ma, L., Shah, B., Panopoulos, A.D., Watowich, S.S., Schluns, K.S., Tian, Q., Jetten, A.M., and Dong, C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR(alpha) and ROR(gamma). Immunity 28(1):29-39 (2008). ] Yan, J., Yang, X.P., Kim, Y.S., and Jette, A.M. RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser205. Cancer research 68 (11):4269-4276 (2008). [Abstract Yan, J., Yang, X.P., Kim, Y.S., and Jette, A.M. RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser205. Cancer research 68(11):4269-4276 (2008). ] Joo, J.H., and Jetten, A.M. NF-kappa B-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. The Journal of biological chemistry 283 (24):16391-16399 (2008). [Abstract Joo, J.H., and Jetten, A.M. NF-kappa B-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. The Journal of biological chemistry 283(24):16391-16399 (2008). ] Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., Shah, B., Chang, S.H., Schluns, K.S., Watowich, S.S., Feng, X.H., Jetten, A.M., and Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29 (1):44-56 (2008). [Abstract Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., Shah, B., Chang, S.H., Schluns, K.S., Watowich, S.S., Feng, X.H., Jetten, A.M., and Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56 (2008). ] Yan, J., and Jetten, A.M. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damabe sites. Cancer letters 271 (2):179-190 (2008). [Abstract Yan, J., and Jetten, A.M. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damabe sites. Cancer letters 271(2):179-190 (2008). ] Angers, M., Uldry, M., Kong, D., Gimble, J.M., and Jetten, A.M. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein induced in brown adipose tissue during fasting and adaptive thermogenesis. The Biochemical journal 416 (3):347-355 (2008). [Abstract Angers, M., Uldry, M., Kong, D., Gimble, J.M., and Jetten, A.M. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein induced in brown adipose tissue during fasting and adaptive thermogenesis. The Biochemical journal 416(3):347-355 (2008). ] Wada, T., Kang, H.S., Jetten, A.M., and Xie, W. The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Experimental biology and medicine 233 (10):1191-1201 (2008). [Abstract Wada, T., Kang, H.S., Jetten, A.M., and Xie, W. The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Experimental biology and medicine 233(10):1191-1201 (2008). ] Kim, Y.S., Kang, H.S., Herbert, R., Beak, J.Y., Collins, J.B., Grissom, S.F., and Jetten, A.M. Deficient Krüppel-like zinc finger protein Glis2 expression in mice results in progressive chronic kidney disease and renal failure. Molecular and Cellular Biology 28 (7):2358-2367 (2008). [Abstract Kim, Y.S., Kang, H.S., Herbert, R., Beak, J.Y., Collins, J.B., Grissom, S.F., and Jetten, A.M. Deficient Krüppel-like zinc finger protein Glis2 expression in mice results in progressive chronic kidney disease and renal failure. Molecular and Cellular Biology 28(7):2358-2367 (2008). ] Nurieva, R.I., Chung, Y., Hwang, D., Yang, X.O., Kang, H.S., Ma, L., Wang, Y., Watowich, S.S., Jetten, A.M., Tian, Q., and Dong, C. Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages. Immunity 29 (1):138-149 (2008). [Abstract Nurieva, R.I., Chung, Y., Hwang, D., Yang, X.O., Kang, H.S., Ma, L., Wang, Y., Watowich, S.S., Jetten, A.M., Tian, Q., and Dong, C. Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages. Immunity 29(1):138-149 (2008). ] Kang, H.S., Beak, J.Y., Kim, Y.S., Herbert, R., and Jetten, A.M. Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Molecular and cellular biology 29 (10):2556-2569 (2009). [Abstract Kang, H.S., Beak, J.Y., Kim, Y.S., Herbert, R., and Jetten, A.M. Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Molecular and cellular biology 29(10):2556-2569 (2009). ] Jetten, A.M. Retinoid-related Orphan Receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nuclear receptor signaling 7 :e003 (2009). [Abstract Jetten, A.M. Retinoid-related Orphan Receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nuclear receptor signaling 7:e003 (2009). ] Chen, Y., Coulter, S., Jetten, A.M., and Goldstein, J.A. Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. J Pharmacol. Exper. Ther. 329 (1):192-201 (2009). [Abstract Chen, Y., Coulter, S., Jetten, A.M., and Goldstein, J.A. Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. J Pharmacol. Exper. Ther. 329(1):192-201 (2009). ] Yan, J., Menendez, D., Yang, X-P., Reznick, M.A., and Jetten, A.M. A regulatory loop composed of Rap80-HDM2-p53 provides Rap80 enhanced p53 degradation by HDM2 in response to DNA damage. The Journal of biological chemistry 284 (29):19280-19289 (2009). [Abstract Yan, J., Menendez, D., Yang, X-P., Reznick, M.A., and Jetten, A.M. A regulatory loop composed of Rap80-HDM2-p53 provides Rap80 enhanced p53 degradation by HDM2 in response to DNA damage. The Journal of biological chemistry 284(29):19280-19289 (2009). ] Nagatake, T., Fukuyama, S., Kim, D.Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A.M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of experimental medicine 206 (11):2351-2364 (2009). [Abstract Nagatake, T., Fukuyama, S., Kim, D.Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A.M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of experimental medicine 206(11):2351-2364 (2009). ] Joo, J.H., and Jetten, A.M. Molecular mechanisms involved in farnesol-induced apoptosis. Cancer letters 287 (2):123-135 (2009). [Abstract Joo, J.H., and Jetten, A.M. Molecular mechanisms involved in farnesol-induced apoptosis. Cancer letters 287(2):123-135 (2009). ] Kang, H.S., Kim, Y.S., ZeRuth, G., Beak, J.Y., Gerrish, K., Kilic, G., Sosa-Pineda, B., Jensen, J., Pierreux, C.E., Lemaigre, F.P., Foley, J., and Jetten, A.M. Transcription factor Glis3, a novel critical player in the regulation of pancreatic b-cell development and insulin gene expression. Molecular and cellular biology 29 (24):6366-6379 (2009). [Abstract Kang, H.S., Kim, Y.S., ZeRuth, G., Beak, J.Y., Gerrish, K., Kilic, G., Sosa-Pineda, B., Jensen, J., Pierreux, C.E., Lemaigre, F.P., Foley, J., and Jetten, A.M. Transcription factor Glis3, a novel critical player in the regulation of pancreatic b-cell development and insulin gene expression. Molecular and cellular biology 29(24):6366-6379 (2009). ] Martinez, G.J., Zhang, Z., Chung, Y., Reynolds, J.M., Lin, X., Jetten, A.M., Feng, X-H., and Dong, C. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. Journal of Biological Chemistry 284 (51):35283-35286 (2009). [Abstract Martinez, G.J., Zhang, Z., Chung, Y., Reynolds, J.M., Lin, X., Jetten, A.M., Feng, X-H., and Dong, C. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. Journal of Biological Chemistry 284(51):35283-35286 (2009). ] Stapleton, C.M., Joo, J.H., Kim, Y-S, Liao, G., Panettieri, R.A., and Jetten, A.M. Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. Experimental Cell Research 316 (4):507-516 (2010). [Abstract Stapleton, C.M., Joo, J.H., Kim, Y-S, Liao, G., Panettieri, R.A., and Jetten, A.M. Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. Experimental Cell Research 316(4):507-516 (2010). ] Jetten, A.M. The KRAS and NF-kB connection: role in lung cancer development and potential for therapeutic intervention. Cellscience Reviews 6 (3):56-62 (2010). [Abstract Jetten, A.M. The KRAS and NF-kB connection: role in lung cancer development and potential for therapeutic intervention. Cellscience Reviews 6(3):56-62 (2010). ] Kang, H.S., ZeRuth, G., Lichti-Kaiser, K., Vasanth, S., Yin, Z., Kim, Y.S., and Jetten, A.M. GLI-similar (GLIS) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histology and histopathology 25 (11):1481-1496 (2010) [Abstract Kang, H.S., ZeRuth, G., Lichti-Kaiser, K., Vasanth, S., Yin, Z., Kim, Y.S., and Jetten, A.M. GLI-similar (GLIS) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histology and histopathology 25(11):1481-1496 (2010) ] Kim, Y.S., Harry, G.J., Kang, H.S., Goulding, D., Wine, R., Kissling, G.E., Liao, G., and Jetten, A.M. Altered Cerebellar Development in Nuclear Receptor TAK1/TR4 Null Mice is Associated with Deficits in GLAST+ Glia, Alterations in Social Behavior, Motor Learning, Startle Reactivity, and Microglia. Cerebellum (London, England) 9 (3):310-323 (2010). [Abstract Kim, Y.S., Harry, G.J., Kang, H.S., Goulding, D., Wine, R., Kissling, G.E., Liao, G., and Jetten, A.M. Altered Cerebellar Development in Nuclear Receptor TAK1/TR4 Null Mice is Associated with Deficits in GLAST+ Glia, Alterations in Social Behavior, Motor Learning, Startle Reactivity, and Microglia. Cerebellum (London, England) 9(3):310-323 (2010). ] Kang, H.S., Okamoto, K., Kim, Y.S., Bortner, C.D., Dang, H., Wada, T., Xie, W., Yang, X-P., Liao, G., and Jetten, A.M. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes 60 (1):177-188 (2010). [Abstract Kang, H.S., Okamoto, K., Kim, Y.S., Bortner, C.D., Dang, H., Wada, T., Xie, W., Yang, X-P., Liao, G., and Jetten, A.M. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes 60(1):177-188 (2010). ] Vasanth, S., ZeRuth, G., Kang, H.S., and Jetten, A.M. Identification of nuclear localization, DNA binding and transactivating mechanisms of Krüppel-like zinc finger protein Gli-similar 2 (Glis2). The Journal of biological chemistry 286 (6):4749-4759 (2011). [Abstract Vasanth, S., ZeRuth, G., Kang, H.S., and Jetten, A.M. Identification of nuclear localization, DNA binding and transactivating mechanisms of Krüppel-like zinc finger protein Gli-similar 2 (Glis2). The Journal of biological chemistry 286(6):4749-4759 (2011). ] Palmer, M.T., Lee, Y.K., Maynard, C.L., Oliver, J.R., Bikle, D.D., Jetten, A.M., and Weaver, C.T. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. The Journal of biological chemistry 286 (2):997-1004 (2011). [Abstract Palmer, M.T., Lee, Y.K., Maynard, C.L., Oliver, J.R., Bikle, D.D., Jetten, A.M., and Weaver, C.T. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. The Journal of biological chemistry 286(2):997-1004 (2011). ] ZeRuth, G., Yang, X.P., and Jetten, A.M. Modulation of the Transactivation Function and Stability of Krüppel-like Zinc Finger Protein Gli-similar 3 (Glis3) by Suppressor of Fused. The Journal of biological chemistry 286 (25):22077-22089 (2011). [Abstract ZeRuth, G., Yang, X.P., and Jetten, A.M. Modulation of the Transactivation Function and Stability of Krüppel-like Zinc Finger Protein Gli-similar 3 (Glis3) by Suppressor of Fused. The Journal of biological chemistry 286(25):22077-22089 (2011). ] Jetten, A.M. A helping hand against autoimmunity. Nature 472 (7344):421-422 (2011). [Abstract Jetten, A.M. A helping hand against autoimmunity. Nature 472(7344):421-422 (2011). ] Kang, H.S., Okamoto, K., Takeda, Y., Beak, J.Y., Gerrish, K., Bortner, C.D., DeGraff, L.M., Wada, T., Xie, W., and Jetten, A.M. Transcriptional profiling reveals a role for ROR{alpha} in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiological genomics 43 (13):818-828 (2011). [Abstract Kang, H.S., Okamoto, K., Takeda, Y., Beak, J.Y., Gerrish, K., Bortner, C.D., DeGraff, L.M., Wada, T., Xie, W., and Jetten, A.M. Transcriptional profiling reveals a role for ROR{alpha} in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiological genomics 43(13):818-828 (2011). ] Takeda Y, Jothi R, Birault V, Jetten AM. RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Research. 40(17) :8519-35 (2012). [Abstract Takeda Y, Jothi R, Birault V, Jetten AM. RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Research. 40(17):8519-35 (2012). ] Kim YS, Kang HS, Takeda Y, Hom L, Song HY, Jensen J, Jetten AM. Glis3 regulates neurogenin 3 expression in pancreatic β-cells and interacts with its activator, Hnf6. Molecules and cells 34 (2):193-200 (2012). [Abstract Kim YS, Kang HS, Takeda Y, Hom L, Song HY, Jensen J, Jetten AM. Glis3 regulates neurogenin 3 expression in pancreatic β-cells and interacts with its activator, Hnf6. Molecules and cells 34(2):193-200 (2012). ] Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nature medicine 18 (8):1248-1253 (2012). [Abstract Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nature medicine 18(8):1248-1253 (2012). ] Yin Z, Menendez D, Resnick MA, French JE, Janardhan KS, Jetten AM. RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Research 72 (19):5080-5090 (2012). [Abstract Yin Z, Menendez D, Resnick MA, French JE, Janardhan KS, Jetten AM. RAP80 is critical in maintaining genomic stability and suppressing tumor development. Cancer Research 72(19):5080-5090 (2012). ] Jetten AM, Kang HS, Takeda Y. Retinoic acid-related orphan receptors (ROR) α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity. Frontiers in diabetes 2013 4 (1):epub-. [Abstract Jetten AM, Kang HS, Takeda Y. Retinoic acid-related orphan receptors (ROR) α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity. Frontiers in diabetes 2013 4(1):epub-. ] Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC. (2013) Cyclooxygenase-2 Inhibits T Helper Cell Type 9 Differentiation during Allergic Lung Inflammation via Down-regulation of IL-17RB. Am J Respir Crit Care Med 187:812-822. [Abstract Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC. (2013) Cyclooxygenase-2 Inhibits T Helper Cell Type 9 Differentiation during Allergic Lung Inflammation via Down-regulation of IL-17RB. Am J Respir Crit Care Med 187:812-822. ] Kang HS, Liao G, DeGraff LM, Bortner CD, Garantziotis S, Jetten AM. CD44 deficiency reduces the susceptibility to diet-induced adipose inflammation, hepatic steatosis, and insulin resistance. Diabetes 8 (3):e58417- (2013). [Abstract Kang HS, Liao G, DeGraff LM, Bortner CD, Garantziotis S, Jetten AM. CD44 deficiency reduces the susceptibility to diet-induced adipose inflammation, hepatic steatosis, and insulin resistance. Diabetes 8(3):e58417- (2013). ] Teng CT, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions 2013 203(3): 556-564. [Abstract Teng CT, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions 2013 203(3): 556-564. ] Zeruth GT, Takeda Y, Jetten AM. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular Endocrinology 2013 27(10):1692-1705. [Abstract Zeruth GT, Takeda Y, Jetten AM. The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Molecular Endocrinology 2013 27(10):1692-1705. ] Teng CT, Beams B, Alex Merrick B, Martin N, Romeo C, Jetten AM. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Biochemical and biophysical research communications 2014 444 (2):177-181. [Abstract Teng CT, Beams B, Alex Merrick B, Martin N, Romeo C, Jetten AM. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Biochemical and biophysical research communications 2014 444(2):177-181. ] Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Broz˙yna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC, Jetten AM. RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2014 28(7):2775-2789. [Abstract Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Broz˙yna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC, Jetten AM. RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2014 28(7):2775-2789. ] Lichti-Kaiser K, ZeRuth G, Jetten AM. Transcription Factor Gli-Similar 3 (GLIS3): Implications for the development of congenital hypothyroidism. Journal of endocrinology, diabetes & obesity 2014 2(2):1024-. [Abstract Lichti-Kaiser K, ZeRuth G, Jetten AM. Transcription Factor Gli-Similar 3 (GLIS3): Implications for the development of congenital hypothyroidism. Journal of endocrinology, diabetes & obesity 2014 2(2):1024-. ] Takeda, Y., Kang, H.S., Lih, F.B., Jiang, H., Blaner, W.S., and Jetten, A.M. Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucl. Acids Res . 42 :10448-59 (2014). [Abstract Takeda, Y., Kang, H.S., Lih, F.B., Jiang, H., Blaner, W.S., and Jetten, A.M. Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucl. Acids Res. 42:10448-59 (2014). ] Xie L, Qi Y, Subashi E, Liao G, Miller DeGraff L, Jetten AM, Johnson GA. 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. NMR in biomedicine 2015 28 (5):546-554. [Abstract Xie L, Qi Y, Subashi E, Liao G, Miller DeGraff L, Jetten AM, Johnson GA. 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. NMR in biomedicine 2015 28(5):546-554. ] ZeRuth G, Williams JG, Cole YC, Jetten AM. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PloS one 2015 10(7):e0131303-. [Abstract ZeRuth G, Williams JG, Cole YC, Jetten AM. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PloS one 2015 10(7):e0131303-. ] Cook DN, Kang HS, Jetten AM. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism. Nuclear receptor research 2015 2():-. [Abstract Cook DN, Kang HS, Jetten AM. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism. Nuclear receptor research 2015 2():-. ] Kojima H, Takeda Y, Muromoto R, Takahashi M, Hirao, T, Takeuchi S, Jetten AM, Matsuda T. Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Environ Toxicology 2015 329():32-39. [Abstract Kojima H, Takeda Y, Muromoto R, Takahashi M, Hirao, T, Takeuchi S, Jetten AM, Matsuda T. Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Environ Toxicology 2015 329():32-39. ] Slominski AT, Zmijewski M, Jetten AM. ROR alpha is not a receptor for melatonin. BioEssays: news and reviews in molecular, cellular and developmental biology 2016 38(12):119-1194. [Abstract Slominski AT, Zmijewski M, Jetten AM. ROR alpha is not a receptor for melatonin. BioEssays: news and reviews in molecular, cellular and developmental biology 2016 38(12):119-1194. ] Smith SH, Peredo CE, Takeda Y, Bui T , Neil J, Rickard D, Millerman E, Therrien JP, Nicodeme E, Brusq J-M, Birault V, Viviani F, Hofland H , Jetten, AM , Cote-Sierra, J. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PloS one 2016 11(2):-. [Abstract Smith SH, Peredo CE, Takeda Y, Bui T , Neil J, Rickard D, Millerman E, Therrien JP, Nicodeme E, Brusq J-M, Birault V, Viviani F, Hofland H , Jetten, AM , Cote-Sierra, J. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin. PloS one 2016 11(2):-. ] Kang HS, Takeda Y, Jeon K, Jetten AM.The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PloS one 2016 Jun 7;11(6):e0157138 [Abstract Kang HS, Takeda Y, Jeon K, Jetten AM.The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PloS one 2016 Jun 7;11(6):e0157138 ] Tian L, Dooley J, Schonefeldt S, Carr EJ, Garcia-Perez JE, Overbergh L , Vandenbussche J, Allemeersch J , Franckaert D, Dahlstrom J, Socha L, Delghingaro-Augusto V, Gevaert K, Jetten AM, Lambrechts DM, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM , Liston A. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nature Genetics 2016 48(5):519-527. [Abstract Tian L, Dooley J, Schonefeldt S, Carr EJ, Garcia-Perez JE, Overbergh L , Vandenbussche J, Allemeersch J , Franckaert D, Dahlstrom J, Socha L, Delghingaro-Augusto V, Gevaert K, Jetten AM, Lambrechts DM, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM , Liston A. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nature Genetics 2016 48(5):519-527. ] Scoville, DW, Jetten, AM. Studying pancreas development and diabetes using human pluripotent stem cells. Stem cell investigation 2016 3(80):-. [Abstract Scoville, DW, Jetten, AM. Studying pancreas development and diabetes using human pluripotent stem cells. Stem cell investigation 2016 3(80):-. ] Jeon K, Kumar D, Conway A, Park K-Y, Jothi R , Jetten AM. GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors. Stem Cells 2018 ():-. [Abstract Jeon K, Kumar D, Conway A, Park K-Y, Jothi R , Jetten AM. GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors. Stem Cells 2018 ():-. ] Singer, D., Zhuang, H., Walker, J.V., Jin, H., Wu, X., Marangoni, P., Lu, D., Grayson, P.R.C., Gulsen, T., Ardu, S., Zambon, A., Krejci, I., Luo, S., Jetten, A.M., Tredwin, C., Klein, O.D., Attanasio, M., Cameiliet, P., Huttner, W.B., Corbeil, D., Hu, B. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. The EMBO Journal 2019 38 (2):-. [Abstract Singer, D., Zhuang, H., Walker, J.V., Jin, H., Wu, X., Marangoni, P., Lu, D., Grayson, P.R.C., Gulsen, T., Ardu, S., Zambon, A., Krejci, I., Luo, S., Jetten, A.M., Tredwin, C., Klein, O.D., Attanasio, M., Cameiliet, P., Huttner, W.B., Corbeil, D., Hu, B. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. The EMBO Journal 2019 38(2):-. ] Jetten AM, Cook DN . 2019. (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease. Annual Review of Pharmacology and Toxicology doi: 10.1146/annurev-pharmtox-010919-023711 [Online 6 August 2019]. [Abstract Jetten AM, Cook DN. 2019. (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease. Annual Review of Pharmacology and Toxicology doi: 10.1146/annurev-pharmtox-010919-023711 [Online 6 August 2019]. ] Takeda Y, Kang HS, Jetten AM. 2019. Analysis of the Transcriptional Activity of Retinoic Acid-Related Orphan Receptors (RORs) and Inhibition by Inverse Agonists. Methods in Molecular Biology 1966:193-202. [Abstract Takeda Y, Kang HS, Jetten AM. 2019. Analysis of the Transcriptional Activity of Retinoic Acid-Related Orphan Receptors (RORs) and Inhibition by Inverse Agonists. Methods in Molecular Biology 1966:193-202. ] Scoville DW, Lichti-Kaiser K, Grimm SA, Jetten AM. 2019. Glis3 Binds Pancreatic Beta Cell Regulatory Regions Alongside Other Islet Transcription Factors. Journal of Endocrinology doi: 10.1530/JOE-19-0182 [Online 1 July 2019]. [Abstract Scoville DW, Lichti-Kaiser K, Grimm SA, Jetten AM. 2019. Glis3 Binds Pancreatic Beta Cell Regulatory Regions Alongside Other Islet Transcription Factors. Journal of Endocrinology doi: 10.1530/JOE-19-0182 [Online 1 July 2019]. ] Jetten AM. 2019. Emerging Roles of GLI-Similar Krüppel-like Zinc Finger Transcription Factors in Leukemia and Other Cancers. Trends Cancer 5(9):547-557. [Abstract Jetten AM. 2019. Emerging Roles of GLI-Similar Krüppel-like Zinc Finger Transcription Factors in Leukemia and Other Cancers. Trends Cancer 5(9):547-557. ] Jeon K, Park K, Jetten AM. 2020. Efficient neural differentiation using single-cell culture of human embryonic stem cells. J Vis Exp ; doi: 10.3791/60571 [Online 18 January 2020]. [Abstract Jeon K, Park K, Jetten AM. 2020. Efficient neural differentiation using single-cell culture of human embryonic stem cells. J Vis Exp; doi: 10.3791/60571 [Online 18 January 2020]. ] Slominski RM, Tuckey RC, Manna PR, Jetten AM, Postlethwaite A, Raman C, Slominski AT. 2020. Extra-adrenal Glucocorticoid Biosynthesis: Implications for Autoimmune and Inflammatory Disorders. Genes Immun ; doi: 10.1038/s41435-020-0096-6 [Online 23 March 2020]. [Abstract Slominski RM, Tuckey RC, Manna PR, Jetten AM, Postlethwaite A, Raman C, Slominski AT. 2020. Extra-adrenal Glucocorticoid Biosynthesis: Implications for Autoimmune and Inflammatory Disorders. Genes Immun; doi: 10.1038/s41435-020-0096-6 [Online 23 March 2020]. ] Jin H, Zhang Y, Liu D, Wang SS, Ding Q, Rastogi P, Purvis M, Wang A, Elhadi S, Ren C, Cao C, Chai Y, Igarashi P, Jetten AM, Lu D, Attanasio M. Innate immune signaling contributes to tubular cell senescence in the Glis2 knockout mouse model of nephronophthisis. Am J Pathol 190(1) :176-189 (2020). [Abstract Jin H, Zhang Y, Liu D, Wang SS, Ding Q, Rastogi P, Purvis M, Wang A, Elhadi S, Ren C, Cao C, Chai Y, Igarashi P, Jetten AM, Lu D, Attanasio M. Innate immune signaling contributes to tubular cell senescence in the Glis2 knockout mouse model of nephronophthisis. Am J Pathol 190(1):176-189 (2020). ] Scoville DW, Gruzdev A, Jetten AM. 2020. Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic β-cells. J Mol Endocrinol ; doi: 10.1530/JME-20-0082 [Online 1 July 2020]. [Abstract Scoville DW, Gruzdev A, Jetten AM. 2020. Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic β-cells. J Mol Endocrinol; doi: 10.1530/JME-20-0082 [Online 1 July 2020]. ] Scoville DW, Kang HS, Jetten AM. 2020. Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes. Pharmacol Ther ; doi: 10.1016/j.pharmthera.2020.107632 [Online 18 July 2020]. [Abstract Scoville DW, Kang HS, Jetten AM. 2020. Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes. Pharmacol Ther; doi: 10.1016/j.pharmthera.2020.107632 [Online 18 July 2020]. ] Slominski AT, Slominski RM, Goepfert PA, Kim TK, Holick MF, Jetten AM, Raman C. 2020. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab 319 (2):E455-E457. [Abstract Slominski AT, Slominski RM, Goepfert PA, Kim TK, Holick MF, Jetten AM, Raman C. 2020. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab 319(2):E455-E457. ] Brożyna AA, Kim TK, Zabłocka M, Jóźwicki W, Yue J, Tuckey RC, Jetten AM, Slominski AT. 2020. Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer. Nutrients . 12 (11):3541. [Abstract Brożyna AA, Kim TK, Zabłocka M, Jóźwicki W, Yue J, Tuckey RC, Jetten AM, Slominski AT. 2020. Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer. Nutrients. 12(11):3541. ]Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. 2021. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun . 12 (1):4877. [Abstract Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. 2021. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun. 12(1):4877. ] Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. 2021. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun . 12 (1):4877. [Abstract Nair KS, Srivastava C, Brown RV, Koli S, Choquet H, Kang HS, Kuo YM, Grimm SA, Sutherland C, Badea A, Johnson GA, Zhao Y, Yin J, Okamoto K, Clark G, Borrás T, Zode G, Kizhatil K, Chakrabarti S, John SWM, Jorgenson E, Jetten AM. 2021. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nat Commun. 12(1):4877. ] Jetten AM, Scoville DW, Kang HS. 2022. GLIS1-3: Links to primary cilium, reprogramming, stem cell renewal, and disease. Cells. 2022 Jun 3;11 (11):1833. doi: 10.3390/cells11111833. [Abstract Jetten AM, Scoville DW, Kang HS. 2022. GLIS1-3: Links to primary cilium, reprogramming, stem cell renewal, and disease. Cells. 2022 Jun 3;11(11):1833. doi: 10.3390/cells11111833. ]
Back
