Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
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Stephen S. Ferguson, Ph.D.
Chemist
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Tel 984-287-3128
[email protected]
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P.O. Box 12233
Mail Drop E1-10
Durham, NC 27709
Stephen Ferguson is an Investigator within the Mechanistic Toxicology Branch of the Division of Translational Toxicology (DTT) leading multiple research initiatives to model and predict human responses to chemical exposures. His principal focus seeks to advance the development, qualification, and application of physiologically relevant in vitro screening models and microphysiological systems (MPS) that emulate integrated aspects of tissue functionality (e.g., liver, kidney) and biological response to xenobiotic exposures (e.g., per- and poly-fluorinated alkyl substances (PFAS), botanical mixtures, human therapeutics).
Prior to joining the DTT, Ferguson led the ADME-Tox R&D program of Life Technologies (now Thermo-Fisher) where he and his team developed advanced in vitro liver models and assay systems to predict human drug metabolism, transport, drug-drug interactions and hepatotoxicity. He received his BS and PhD degrees in chemistry and biotechnology from North Carolina State University, and currently serves as adjunct faculty to the Curriculum in Toxicology at the University of North Carolina at Chapel Hill.
Recent Publications
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Ngan D, Sakamuru S, Zhao J, Xia M, Ferguson S, Reif D, Simeonov A, Huang R. Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation.
Toxicology and applied pharmacology.
2025 Jun;499:117315.
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AbstractNgan D, Sakamuru S, Zhao J, Xia M, Ferguson S, Reif D, Simeonov A, Huang R. Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation. Toxicology and applied pharmacology. 2025 Jun
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Liu Y, Lawless M, Roe A, Ferguson S. Integration of computational models to predict botanical phytochemical constituent clearance routes by the extended clearance classification system (ECCS).
Toxicology and applied pharmacology.
2025 May 11 [Epub ahead of print].
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AbstractLiu Y, Lawless M, Roe A, Ferguson S. Integration of computational models to predict botanical phytochemical constituent clearance routes by the extended clearance classification system (ECCS). Toxicology and applied pharmacology. 2025 May 11
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Moyer H, Vergara L, Stephan C, Sakolish C, Ford L, Tsai H, Lin H, Chiu W, Villenave R, Hewitt P, Ferguson S, Rusyn I. Comparative analysis of Caco-2 cells and human jejunal and duodenal enteroid-derived cells in gel- and membrane-based barrier models of intestinal permeability.
Toxicological sciences : an official journal of the Society of Toxicology.
2025 Apr 01;204(2):181-197.
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AbstractMoyer H, Vergara L, Stephan C, Sakolish C, Ford L, Tsai H, Lin H, Chiu W, Villenave R, Hewitt P, Ferguson S, Rusyn I. Comparative analysis of Caco-2 cells and human jejunal and duodenal enteroid-derived cells in gel- and membrane-based barrier models of intestinal permeability. Toxicological sciences : an official journal of the Society of Toxicology. 2025 Apr 01
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Sakolish C, Tsai H, Lin H, Bajaj P, Villenave R, Ferguson S, Stanko J, Becker R, Hewitt P, Chiu W, Rusyn I. Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity.
Biomedicines.
2025 Feb 24;13(3):.
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AbstractSakolish C, Tsai H, Lin H, Bajaj P, Villenave R, Ferguson S, Stanko J, Becker R, Hewitt P, Chiu W, Rusyn I. Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity. Biomedicines. 2025 Feb 24
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Sakolish C, Moyer H, Tsai H, Ford L, Dickey A, Bajaj P, Villenave R, Hewitt P, Ferguson S, Stanko J, Rusyn I. Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform.
Drug metabolism and disposition: the biological fate of chemicals.
2025 Jan;53(1):100001.
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AbstractSakolish C, Moyer H, Tsai H, Ford L, Dickey A, Bajaj P, Villenave R, Hewitt P, Ferguson S, Stanko J, Rusyn I. Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform. Drug metabolism and disposition: the biological fate of chemicals. 2025 Jan
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More Recent Publications from PubMed
