Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Research Summary The Biostatistics and Computational Biology Branch carries out basic and applied research dealing with statistical issues of relevance to environmental health. The branch's members develop new methodologies and apply existing techniques in novel ways to address environmental health problems. Members of the branch also advise institute scientists on computational, study design, database and statistical issues via both long-term and short-term collaboration in research projects throughout NIEHS. The branch also offers training at regular intervals.
Research in the Biostatistics and Computational Biology Branch focuses on several areas:
Design and analysis of laboratory animal toxicology/carcinogenicity experiments and development of improved statistical methods Application and development of methodology for epidemiological and clinical human studies Application and development of new bioinformatics techniques for harvesting information from high-dimensional genomic, gene expression and proteomic data Development of new design and analysis approaches in statistical genetics Development of broadly applicable statistical approaches
Biostatistics & Computational Biology Branch Software
See
Software to access the data or computer instructions developed by members of the NIEHS Biostatistics & Computational Biology Branch.
Recent Publications
Akhtari F, Falk J, Jyoti J, Voutsa V, Cakir E, Salehzadeh-Yazdi A, Hütt M, Lussana A, Marotta F, PEGS DREAM Challenge Community, Ginsburg G, Andreoletti G, Mangul S, Chung V, Albrecht J, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. The PEGS DREAM Challenge: A Crowdsourcing Approach to Understanding Hypercholesterolemia with Multi- dimensional Genomic and Environmental Data.
Research square .
2026 Apr 23 [Epub ahead of print].
[
AbstractAkhtari F, Falk J, Jyoti J, Voutsa V, Cakir E, Salehzadeh-Yazdi A, Hütt M, Lussana A, Marotta F, PEGS DREAM Challenge Community, Ginsburg G, Andreoletti G, Mangul S, Chung V, Albrecht J, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. The PEGS DREAM Challenge: A Crowdsourcing Approach to Understanding Hypercholesterolemia with Multi- dimensional Genomic and Environmental Data. Research square. 2026 Apr 23
]
Resnik D, Conston B, Zhou M, Balin C, Zou J, DeCamp M, Parker J, Shi M. Correction: Does Bioethics Pay Sufficient Attention to Issues Related to Chronic Disease? A Survey of Articles Published in Top Bioethics Journals from 2001 to 2024.
HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues .
2026 Apr 03 [Epub ahead of print].
[
AbstractResnik D, Conston B, Zhou M, Balin C, Zou J, DeCamp M, Parker J, Shi M. Correction: Does Bioethics Pay Sufficient Attention to Issues Related to Chronic Disease? A Survey of Articles Published in Top Bioethics Journals from 2001 to 2024. HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues. 2026 Apr 03
]
Akhtari F, Madenspacher J, D'Agostin D, Shuptrine S, MacNell N, Ritter R, Burkholder A, Xu Z, Mack J, House J, Schaid D, McDonnell S, Schurman S, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. Personalized Environment and Genes Study (PEGS) Dataset-a resource for genomic, exposomic, and geospatial data.
Scientific data .
2026 Apr 02 [Epub ahead of print].
[
AbstractAkhtari F, Madenspacher J, D'Agostin D, Shuptrine S, MacNell N, Ritter R, Burkholder A, Xu Z, Mack J, House J, Schaid D, McDonnell S, Schurman S, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. Personalized Environment and Genes Study (PEGS) Dataset-a resource for genomic, exposomic, and geospatial data. Scientific data. 2026 Apr 02
]
Kockler Z, Bostan H, Klimczak L, Hsiao Y, Dennen M, Cook M, Mertz T, Perelygina L, Kazanov M, Li J, Roberts S, Gordenin D. APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses.
G3 (Bethesda, Md.) .
2026 Mar 28 [Epub ahead of print].
[
AbstractKockler Z, Bostan H, Klimczak L, Hsiao Y, Dennen M, Cook M, Mertz T, Perelygina L, Kazanov M, Li J, Roberts S, Gordenin D. APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses. G3 (Bethesda, Md.). 2026 Mar 28
]
Weinkle J, Glover P, Philips R, Tepper W, Shi M, Resnik D. Conflicts of Interest, Funding Support, and Author Affiliation in Peer-Reviewed Research on the Relationship between Climate Change and Geophysical Characteristics of Hurricanes.
Bulletin of the American Meteorological Society .
2026 Mar;107(3):E356-E371.
[
AbstractWeinkle J, Glover P, Philips R, Tepper W, Shi M, Resnik D. Conflicts of Interest, Funding Support, and Author Affiliation in Peer-Reviewed Research on the Relationship between Climate Change and Geophysical Characteristics of Hurricanes. Bulletin of the American Meteorological Society. 2026 Mar
]
Principal Investigators Applied Statistics
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Bioinformatics
Integrative Bioinformatics Support
Director, Integrative Bioinformatics Support Group
Statistical Methods and Applications in Epidemiology
Publications
Recent Publications
Ye K, Chen Z, Zhao S. Tailoring Bayesian Additive Regression Trees (BART) for environmental mixture studies.
PloS one .
2026;21(5):e0348002.
[
AbstractYe K, Chen Z, Zhao S. Tailoring Bayesian Additive Regression Trees (BART) for environmental mixture studies. PloS one. 2026
]
Perl A, Wu J, Dong J, Brooks A, Yoblinski A, Vierling T, Li J, Ruby D, Radzicki D, Dudek S, Cushman J, Gjoneska E. Immune receptor LAG3 regulates microglia function during Alzheimer's disease.
Neurobiology of disease .
2026 May 11 [Epub ahead of print].
[
AbstractPerl A, Wu J, Dong J, Brooks A, Yoblinski A, Vierling T, Li J, Ruby D, Radzicki D, Dudek S, Cushman J, Gjoneska E. Immune receptor LAG3 regulates microglia function during Alzheimer's disease. Neurobiology of disease. 2026 May 11
]
Akhtari F, Falk J, Jyoti J, Voutsa V, Cakir E, Salehzadeh-Yazdi A, Hütt M, Lussana A, Marotta F, PEGS DREAM Challenge Community, Ginsburg G, Andreoletti G, Mangul S, Chung V, Albrecht J, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. The PEGS DREAM Challenge: A Crowdsourcing Approach to Understanding Hypercholesterolemia with Multi- dimensional Genomic and Environmental Data.
Research square .
2026 Apr 23 [Epub ahead of print].
[
AbstractAkhtari F, Falk J, Jyoti J, Voutsa V, Cakir E, Salehzadeh-Yazdi A, Hütt M, Lussana A, Marotta F, PEGS DREAM Challenge Community, Ginsburg G, Andreoletti G, Mangul S, Chung V, Albrecht J, Fargo D, Schmitt C, Hall J, Motsinger-Reif A. The PEGS DREAM Challenge: A Crowdsourcing Approach to Understanding Hypercholesterolemia with Multi- dimensional Genomic and Environmental Data. Research square. 2026 Apr 23
]
Meng R, BaHammam A, Dzierzewski J, Yang N, Vézina-Im L, Ying Lau E, Sun I, Gregory A, Zeitzer J, Quan S, Dietch J, Szklo-Coxe M, Dautovich N, Stranges S, Tahmasian M, Jean-Louis G, Thompson M, Jackson C, Matricciani L, Tang N, Johnson D, Hale L, Troxel W, de Batlle J, Manconi M, Tondo P, Spiegelhalder K, Stefani A, Knutson K, Wickwire E, Feige B, Bliwise D, Li J, Furihata R, Poyares D, Khazaie H, Taiar R, Boyer F, Jahrami H, Coelho J, Fabbri M, Jiménez-Correa U, Zaki N, Huang M, Ma H, Dong L, St Louis E, Stone K, Spruyt K, Penzel T, Ferri R, Buysse D. Ru-SATED scale and Sleep Health Index: A systematic review of two leading multidimensional sleep health measures and frameworks across the globe.
Sleep medicine reviews .
2026 Apr 18;88:102296.
[
AbstractMeng R, BaHammam A, Dzierzewski J, Yang N, Vézina-Im L, Ying Lau E, Sun I, Gregory A, Zeitzer J, Quan S, Dietch J, Szklo-Coxe M, Dautovich N, Stranges S, Tahmasian M, Jean-Louis G, Thompson M, Jackson C, Matricciani L, Tang N, Johnson D, Hale L, Troxel W, de Batlle J, Manconi M, Tondo P, Spiegelhalder K, Stefani A, Knutson K, Wickwire E, Feige B, Bliwise D, Li J, Furihata R, Poyares D, Khazaie H, Taiar R, Boyer F, Jahrami H, Coelho J, Fabbri M, Jiménez-Correa U, Zaki N, Huang M, Ma H, Dong L, St Louis E, Stone K, Spruyt K, Penzel T, Ferri R, Buysse D. Ru-SATED scale and Sleep Health Index: A systematic review of two leading multidimensional sleep health measures and frameworks across the globe. Sleep medicine reviews. 2026 Apr 18
]
Ding B, Wu Y, Wang X, Song Y, Du H, Sun H, Li J, Hou C. Analysis of Indoor Radon Concentrations in Urban and Rural Areas in 20 Cities - China, 2023-2025.
China CDC weekly .
2026 Apr 03;8(14):418-422.
[
AbstractDing B, Wu Y, Wang X, Song Y, Du H, Sun H, Li J, Hou C. Analysis of Indoor Radon Concentrations in Urban and Rural Areas in 20 Cities - China, 2023-2025. China CDC weekly. 2026 Apr 03
]
More Recent Publications from PubMed
