Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Research Summary The Biostatistics and Computational Biology Branch carries out basic and applied research dealing with statistical issues of relevance to environmental health. The branch's members develop new methodologies and apply existing techniques in novel ways to address environmental health problems. Members of the branch also advise institute scientists on computational, study design, database and statistical issues via both long-term and short-term collaboration in research projects throughout NIEHS. The branch also offers training at regular intervals.
Research in the Biostatistics and Computational Biology Branch focuses on several areas:
Design and analysis of laboratory animal toxicology/carcinogenicity experiments and development of improved statistical methods Application and development of methodology for epidemiological and clinical human studies Application and development of new bioinformatics techniques for harvesting information from high-dimensional genomic, gene expression and proteomic data Development of new design and analysis approaches in statistical genetics Development of broadly applicable statistical approaches
Biostatistics & Computational Biology Branch Software
See
Software to access the data or computer instructions developed by members of the NIEHS Biostatistics & Computational Biology Branch.
Recent Publications
Johnson V, Waidyanatha S, Germolec D, Cora M, Cesta M, Shockley K, Jeffers A, Cimon K, Mutlu E, Cristy T, Pierfellice J, Luster M, Burleson G, Ryan K. Immune System Evaluation of Echinacea Purpurea Root Extract in Female Harlan Sprague Dawley (Hsd:Sprague Dawley SD) Rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association .
2026 Jun 16 [Epub ahead of print].
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AbstractJohnson V, Waidyanatha S, Germolec D, Cora M, Cesta M, Shockley K, Jeffers A, Cimon K, Mutlu E, Cristy T, Pierfellice J, Luster M, Burleson G, Ryan K. Immune System Evaluation of Echinacea Purpurea Root Extract in Female Harlan Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2026 Jun 16
]
Mansouri K, Moreira-Filho J, S Tieghi R, Kleinstreuer N. Democratizing Artificial Intelligence in Toxicology: Real-World Applications and Automated Computational Workflows.
Chemical research in toxicology .
2026 Jun 15;39(6):1072-1083.
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AbstractMansouri K, Moreira-Filho J, S Tieghi R, Kleinstreuer N. Democratizing Artificial Intelligence in Toxicology: Real-World Applications and Automated Computational Workflows. Chemical research in toxicology. 2026 Jun 15
]
Patel C, Miller G, Motsinger-Reif A. Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS).
Environmental science & technology .
2026 Jun 09;60(22):15511-15515.
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AbstractPatel C, Miller G, Motsinger-Reif A. Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS). Environmental science & technology. 2026 Jun 09
]
Lewis J, MacNell N, Buller I, Larson G, Fargo D, Schmitt C, Kirschner L, Reif D, Akhtari F, Justice C, House J, Messier K, Hall J, Motsinger-Reif A. Revisiting the modifiable areal unit problem in the era of exposome-wide association studies: Assessing the performance of the CDC/ATSDR social vulnerability index at privacy-protecting spatial scales.
Environmental research .
2026 May 30;305(Pt 1):124912.
[
AbstractLewis J, MacNell N, Buller I, Larson G, Fargo D, Schmitt C, Kirschner L, Reif D, Akhtari F, Justice C, House J, Messier K, Hall J, Motsinger-Reif A. Revisiting the modifiable areal unit problem in the era of exposome-wide association studies: Assessing the performance of the CDC/ATSDR social vulnerability index at privacy-protecting spatial scales. Environmental research. 2026 May 30
]
Ping J, Jia G, Cai Q, Guo X, Wang J, Tao R, Li B, Bauer J, Xie Y, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Li C, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Ahearn T, Brewster A, Falusi A, Hennis A, Ito H, Kubo M, Lee E, Makumbi T, Mapoko B, Noh D, O'Brien K, Ojengbede O, Olshan A, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Low S, Obafunwa J, Weinberg C, Zhang H, Zhao H, Ambrosone C, Cote M, Huo D, Haiman C, Kang D, Palmer J, Troester M, Shu X, Long J, Zheng W. Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology.
Nature communications .
2026 May 30 [Epub ahead of print].
[
AbstractPing J, Jia G, Cai Q, Guo X, Wang J, Tao R, Li B, Bauer J, Xie Y, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Li C, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Ahearn T, Brewster A, Falusi A, Hennis A, Ito H, Kubo M, Lee E, Makumbi T, Mapoko B, Noh D, O'Brien K, Ojengbede O, Olshan A, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Low S, Obafunwa J, Weinberg C, Zhang H, Zhao H, Ambrosone C, Cote M, Huo D, Haiman C, Kang D, Palmer J, Troester M, Shu X, Long J, Zheng W. Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology. Nature communications. 2026 May 30
]
Principal Investigators Applied Statistics
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Bioinformatics
Integrative Bioinformatics Support
Director, Integrative Bioinformatics Support Group
Statistical Methods and Applications in Epidemiology
Publications
Recent Publications
Oakley R, Sueyoshi T, Ramamoorthy S, Nikolova V, Goulding D, Li J, Ray M, Moy S, Cidlowski J. Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology .
2026 Jun 30;40(12):e72040.
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AbstractOakley R, Sueyoshi T, Ramamoorthy S, Nikolova V, Goulding D, Li J, Ray M, Moy S, Cidlowski J. Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2026 Jun 30
]
Bai L, Qian C, Li J, Zhang X, Zhao Y, Zhang Q, Cao D, Wang Y, Jiang G. Redefining Photoinitiator Risk Prioritization by Bridging Environmental Fate and Human Internal Exposure.
Environmental science & technology .
2026 Jun 09;60(22):16017-16028.
[
AbstractBai L, Qian C, Li J, Zhang X, Zhao Y, Zhang Q, Cao D, Wang Y, Jiang G. Redefining Photoinitiator Risk Prioritization by Bridging Environmental Fate and Human Internal Exposure. Environmental science & technology. 2026 Jun 09
]
Sakamachi Y, Wiley E, Trempus C, Jacobs H, Solis A, Johnson C, Meng X, Hussain S, Roselli A, Lipinski J, O'Dwyer D, Randall T, Malphurs J, Papas B, Wu B, Li Y, Kugler M, Mehta S, Scappini E, Thomas S, Li J, Zhou L, Karmaus P, Lih F, Fessler M, McGrath J, Gibson K, Kass D, Gleiberman A, Andrianova E, Walts A, Invernizzi R, Molyneaux P, Yang I, Zhang Y, Kaminski N, Segal L, Schwartz D, Gudkov A, Garantziotis S. Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF.
Science translational medicine .
2026 Jun 03;18(852):eadw1028.
[
AbstractSakamachi Y, Wiley E, Trempus C, Jacobs H, Solis A, Johnson C, Meng X, Hussain S, Roselli A, Lipinski J, O'Dwyer D, Randall T, Malphurs J, Papas B, Wu B, Li Y, Kugler M, Mehta S, Scappini E, Thomas S, Li J, Zhou L, Karmaus P, Lih F, Fessler M, McGrath J, Gibson K, Kass D, Gleiberman A, Andrianova E, Walts A, Invernizzi R, Molyneaux P, Yang I, Zhang Y, Kaminski N, Segal L, Schwartz D, Gudkov A, Garantziotis S. Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF. Science translational medicine. 2026 Jun 03
]
Lewis J, MacNell N, Buller I, Larson G, Fargo D, Schmitt C, Kirschner L, Reif D, Akhtari F, Justice C, House J, Messier K, Hall J, Motsinger-Reif A. Revisiting the modifiable areal unit problem in the era of exposome-wide association studies: Assessing the performance of the CDC/ATSDR social vulnerability index at privacy-protecting spatial scales.
Environmental research .
2026 May 30;305(Pt 1):124912.
[
AbstractLewis J, MacNell N, Buller I, Larson G, Fargo D, Schmitt C, Kirschner L, Reif D, Akhtari F, Justice C, House J, Messier K, Hall J, Motsinger-Reif A. Revisiting the modifiable areal unit problem in the era of exposome-wide association studies: Assessing the performance of the CDC/ATSDR social vulnerability index at privacy-protecting spatial scales. Environmental research. 2026 May 30
]
Ping J, Jia G, Cai Q, Guo X, Wang J, Tao R, Li B, Bauer J, Xie Y, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Li C, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Ahearn T, Brewster A, Falusi A, Hennis A, Ito H, Kubo M, Lee E, Makumbi T, Mapoko B, Noh D, O'Brien K, Ojengbede O, Olshan A, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Low S, Obafunwa J, Weinberg C, Zhang H, Zhao H, Ambrosone C, Cote M, Huo D, Haiman C, Kang D, Palmer J, Troester M, Shu X, Long J, Zheng W. Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology.
Nature communications .
2026 May 30 [Epub ahead of print].
[
AbstractPing J, Jia G, Cai Q, Guo X, Wang J, Tao R, Li B, Bauer J, Xie Y, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Li C, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Ahearn T, Brewster A, Falusi A, Hennis A, Ito H, Kubo M, Lee E, Makumbi T, Mapoko B, Noh D, O'Brien K, Ojengbede O, Olshan A, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Low S, Obafunwa J, Weinberg C, Zhang H, Zhao H, Ambrosone C, Cote M, Huo D, Haiman C, Kang D, Palmer J, Troester M, Shu X, Long J, Zheng W. Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology. Nature communications. 2026 May 30
]
More Recent Publications from PubMed
