Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Branch
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Cynthia V. Rider, Ph.D.
Toxicologist -
Tel 984-287-3175
[email protected] -
P.O. Box 12233Mail Drop K2-12Durham, NC 27709
Cynthia Rider, Ph.D., is a toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences (NIEHS). As a study scientist, she designs and evaluates results from toxicological studies of chemicals selected for investigation by the NTP. She is particularly interested in developing and refining methods for evaluating the toxicity of mixtures to inform risk assessment. Currently, she is the project leader for polycyclic aromatic compounds, which are being used as a case study to evaluate the joint action of chemicals with component-based approaches (e.g., dose addition models). She is also leading an effort to inform the safety evaluation of complex mixtures. Toward this goal, she is using botanical dietary supplements, such as Ginkgo biloba extract, to develop methods for determining sufficient similarity of complex mixtures. Rider serves as co-chair with Danielle Carlin, Ph.D., of the NIEHS Combined Exposure/Mixtures working group, which aims to advance mixtures research throughout the Institute.
Rider received her B.S. from Tulane University, New Orleans, LA in Environmental Studies and Biology and her Ph.D. from North Carolina State University, Raleigh, NC in Environmental Toxicology. She completed post doctoral training in the Reproductive Toxicology Branch of the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency and the Nicholas School of the Environment at Duke University. She joined the NTP in 2010.
Recent Publications
- Johnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice. Frontiers in toxicology. 2025;7:1558639. [ AbstractJohnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice. Frontiers in toxicology. 2025 ]
- Payton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research. Frontiers in toxicology. 2025;7:1535098. [ AbstractPayton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research. Frontiers in toxicology. 2025 ]
- Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system. Toxicological sciences : an official journal of the Society of Toxicology. 2025 May 01;205(1):191-204. [ AbstractParham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system. Toxicological sciences : an official journal of the Society of Toxicology. 2025 May 01 ]
- Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar;66(3):99-121. [ AbstractCarberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar ]
- Firman J, Boobis A, Hollnagel H, Kaiser S, Lovell D, Moretto A, Mueller S, Rider C, Schmidt F, Stice S, Wijeyesakere S, Borja G, Patlewicz G. Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Dec;194:115070. [ AbstractFirman J, Boobis A, Hollnagel H, Kaiser S, Lovell D, Moretto A, Mueller S, Rider C, Schmidt F, Stice S, Wijeyesakere S, Borja G, Patlewicz G. Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Dec ]
NTP Reports
- National Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice. Toxicity report series. 2016 May [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice. Toxicity report series. 2016 May ]