PI, Institution:
Catherine Metayer, University of California Berkeley

Grant: R24ES028524

The Childhood Leukemia Environmental Research cohort consists of more than 2,000 children with childhood leukemia (CL). These include two existing NIEHS-funded environmental case-control studies of CL conducted in ethnically-diverse populations: the California Childhood Leukemia Study (CCLS), and the CRECERÉ study in Guatemala. The CCLS includes 2213 CL cases and 1310 controls, making it the most comprehensive CL study worldwide. Additional information about the CCLS can also be found with the Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE). For more information about this cohort, visit the NIEHS Epidemiology Resources webpage for CCLS.

Cohort Maintenance & Enrichment Activities:
Enhancing the infrastructure of studies in California and Guatemala, which will contribute to emerging areas of CL-focused research and provide insights underlying the observed ethnic disparity of CL risk in Latin American populations. Curating and managing the inventory of existing biospecimens, dust samples, data from medical records, interviews, geographic information systems, and lab assays. Measuring novel biomarkers of psychosocial stress during pregnancy.

Data Management & Sharing Activities:
Upgrading biorepository and database capabilities to facilitate sharing of resources for new studies of CL prevention, detection, and intervention. Enhancing data sharing procedures by improving the relational databases used for timely data queries and project planning. Developing a database for tracking requests. Designing a website for data sharing.

Data Access:
The data that support the findings of this study are available on request from the two study PIs. For the CCLS, please contact Catherine Metayer. For the CRECERÉ, please contact Libby Morimoto.

Please see NIH RePORTER for publications associated with this R24 grant.