Increased Risk of Chronic Disease Due to Domoic Acid Exposure With Age

NIEHS Grant: R01ES030319

David J. Marcinek, Ph.D.

Domoic acid (DA) is a seafood toxin which can harm the central nervous system. Consumption of DA contaminated shellfish by marine mammals and humans can lead to seizures and death. Researchers from the University of Washington are investigating how age may affect a person’s susceptibility to DA-related disease. They will use both young and old mouse models to assess the effects of short- and long-term low-level DA exposure on brain, heart, and kidney function. Researchers will also examine whether DA exposure leads to a decline in mitochondrial function in these systems. This study will provide insight into how low-level exposure to DA through seafood consumption can contribute to the development of chronic disease and guide development of interventions to reduce DA-related disease risk.