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NIEHS Studies
Title Topic/Condition Location Join A Study
A Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics and COVID-19 Study This study is a prospective, longitudinal, observational, single-center, exploratory study to collect samples and data that will enable explorations of the interaction between smoking, immune system characteristics and Coronavirus Disease 2019 (COVID-19). This study will collect baseline samples and data prior to COVID-19 infection required to explore these interactions prospectively.

Research Triangle Park, NC

Adult and Juvenile Myositis (Studies in the Natural History & Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies) This study will evaluate subjects with adult- and childhood-onset myositis to learn more about the cause of the disease and associated immune system changes.

Bethesda, MD

Study Overview Adult and Juvenile Myositis
Biosample Repository Study This repository will allow us to collect and store commonly utilized human biological samples (whole blood, plasma, urine, and DNA) that can be used for future laboratory procedure development, assay development, and validation, analysis of analyte degradation over time, quality control testing and exploration of scientific hypotheses.
Bisphenol A (BPA) Pharmacokinetic (PK): Controlled Exposure Study This is a study on the controlled exposure of BPA and its effects on the body.

Research Triangle Park, NC

Black Cohosh Study Black Cohosh is an herbal supplement that is taken by some women to treat hot flashes, cramps, or other related symptoms. Researchers are studying the health effects of black cohosh in women who have been taking the supplement for at least 3 months. Researchers are investigating whether black cohosh may affect folate and B12 levels, anemia, and metabolomics profiles. They are also investigating whether black cohosh induces genetic changes.

Research Triangle Park, NC

Blood Vessel Study Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases.

Research Triangle Park, NC

Body Weight & Puberty Study (Investigating the Impact of Obesity on Pubertal Development in Girls) Researchers want to find out if body weight affects when a girl starts puberty

Research Triangle Park, NC

BPA Monitoring Study in Cashiers The study was designed to measure BPA levels before and after occupation exposure to cash register thermal paper.

Research Triangle Park, NC

Calcinosis Study Study of Sodium Thiosulfate for Treatment of Calcinosis Associated with Juvenile and Adult Dermatomyositis

Bethesda, MD

Cockroach Allergen Intervention The purpose of this study was to determine how intensive an effective extermination must be.

Research Triangle Park, NC

Community Resiliency, Environmental Action, and Collaborations for Health (REACH) Equity Study This research study seeks to understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based programs for recovery and resiliency.

Research Triangle Park, NC

Study Overview: Community Resiliency, Environmental Action, and Collaborations for Health (REACH) Equity Study
Cox-2 Gene and the Immune System The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system.

Research Triangle Park, NC

Dust Mite Reduction Study The study delved into whether in-home test kits decreased dust mite allergen levels in homes with children who are sensitive to dust mites.

Bethesda, MD

E-Cigs and Smoking Study Researchers are trying to develop new biomarkers of tobacco smoke exposure and e-cigarette use.

Research Triangle Park, NC

Environmental Causes of Infertility This study will use menstrual fluid as a source of endometrial cells for deriving primary cultures of stromal cells and epithelial cell organoids.

Research Triangle Park, NC

Environmental Exposure and Injury Study This study aims to identify the interaction of host and environmental factors in the response to injury and the development of disease, and to develop better methodological tools that quantify host-environmental interactions in health and disease.

Research Triangle Park, NC

Exposure to Indoor Allergens in Day Care Facilities The study evaluated allergen levels and their predictors in day care facilities.
Girl’s Menstrual Health Study The broad goal of these studies is to determine the physiologic and pathophysiologic underpinnings of irregular menstrual cycles among adolescents in the early postmenarchal period.

Research Triangle Park, NC

Study Overview: Demystifying a Girl’s First Period
Healthy Homes The purpose of the study is to learn how to make homes more supportive of healthy eating and physical activity.

Emory University, Centers for Disease Control and Prevention, Southwest Georgia Cancer Coalition

Immunity Cells in Blood (Innate Immunity Signal Transduction in Human Leukocytes) To investigate the response of immune cells from the bloodstream.

Research Triangle Park, NC

Inflammatory Response to DNA Damage (Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage) The study will look at how changes in the tumor suppressor gene p53 lead to changes in inflammation and the ability to repair DNA damage.

Research Triangle Park, NC

Study Overview: Inflammatory Response to DNA Damage
Inflammatory Response to Endotoxin (Effect of Innate Immunity on the Inflammatory Response to Endotoxin) This study will look at how differences in people’s genes may cause differences in their blood cells’ response to exposed environmental factors

Research Triangle Park, NC

Study Overview: Inflammatory Response to Endotoxin
Inner-City Asthma Study (ICAS) ICAS Study evaluates the effectiveness of two types of interventions to reduce the prevalence and severity of asthma in children.

Research Triangle Park, NC

Lung Inflammation Study This prospective, cross-sectional study is designed to investigate the role of cytochrome P450 (CYP), including the EPHX2 and CYP2J2 proteins, in macrophage function and inflammatory response in adult volunteers who meet eligibility criteria to undergo bronchoscopy.

Research Triangle Park, NC

Metabolic Disease (Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease) NIEHS Investigators will look at how differences in people’s genes may cause their body to respond in different ways to glucocorticoids. Glucocorticoids are hormones made by the human body that are essential for life but in excess may cause diseases such as obesity and diabetes.

Research Triangle Park, NC

Molecular Basis of Inherited Reproductive Disorders Study During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other people may have a normal puberty but develop reproductive disorders later in life. Researchers want to study people with reproductive disorders to learn more about how these disorders may be inherited.

Research Triangle Park, NC


 

Bethesda, MD

Study Overview: Inherited Reproductive Disorders Study
Myositis in Military Personnel (Environmental Risk Factors for the Development of Myositis in Military Personnel) Researchers will compare military personnel with and without myositis to look for common factors that may have led to the disease.

Bethesda, MD

National Health & Nutrition Examination Survey (NHANES) NHANES allowed researchers to examine the role of diet, obesity, diabetes, and genetics in the development of allergic disease.
National Survey of Lead & Allergens in Housing (NSLAH) NSLAH measures levels of lead in dust, soil, and paint, and the levels of various indoor allergens in floor and bedding dust.

Research Triangle Park, NC

NHALES Study (Natural History of Asthma with Longitudinal Environmental Sampling) The study will help scientists understand how bacteria and other factors in the environment affect people who have moderate to severe asthma.

Research Triangle Park, NC

Study Overview: NHALES Asthma Study
NIEHS-EPA Pilot Study of Exposure to Chemicals in Consumer Products This study intends to test and improve the ways that studies gather data about how chemicals in products come in contact with consumers.

Research Triangle Park, NC

Nutrition and Menstrual Cycles Study (CaREFREE Study: Calorie Restriction, Environment, and Fitness: Reproductive Effects Evaluation) This study intends to understand how nutrition, fitness, and the environment affect women's reproductive cycles.

Research Triangle Park, NC

Observation of Environment and Reproductive-Endocrine Effects This study will investigate the relationship between environment, lifestyle, and reproductive function.

Research Triangle Park, NC

Studies Overview: Environmental Impact on Adult Hormones and Reproductive Health & Environmental Impact on Children’s H…
PEGS: Personalized Environment and Genes Study

Research Triangle Park, NC

Study Overview: Personalized Environment and Genes Study (PEGS)
Plasma Study This project will look at how oxidative stress occurs in smokers compared to non-smokers.

Research Triangle Park, NC

Polycystic Ovary Syndrome in Twin Sisters The goal of this study is to find out whether polycystic ovary syndrome in twins is caused by genetics, environmental triggers or a combination of both.

Research Triangle Park, NC

Psoriasis Study Researchers are studying the differences in immune response between a person with psoriasis, a person with chronic inflammatory disease and a healthy person.

Research Triangle Park, NC

Rheumatic Disorders in Siblings (Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders) The research team will study the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, in which one has the disease and the other does not.

Bethesda, MD

RSV Infection and Asthma (TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV Infection) NIEHS scientists will explore whether there is a difference in lung cells from healthy and asthmatic participants and how these cells respond to exposure to respiratory syncytial virus (RSV), a very common virus that leads to cold-like symptoms. The study will also evaluate if a protein in lung cells called TGF-Beta increases risk of infection with RSV.

Research Triangle Park, NC

Sample Collection Registry (Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing) Researchers are developing a registry of biologic and environmental samples with which to develop and test specific laboratory assays.

Research Triangle Park, NC

Serological Surveillance for COVID-19 in Central North Carolina This study aims to characterize the proportion of people with detectable antibodies to SARS-CoV-2, the rate of asymptomatic carriers, the natural history of antibody titers, and association of demographic and medical factors.

Research Triangle Park, NC

Teenage Menstrual Health Study The broad goal of this study is to determine the cause of irregular menstrual cycles in teenage girls. Study Overview: Teenage Menstrual Health Study
The Investigation of Vitamin D and Menstrual Cycles Trial: A Phase II Clinical Trial This Phase II clinical trial translates both animal studies and human observational research into public health relevant research. We will investigate vitamin D’s influence on the hypothalamic-pituitary-ovarian axis by careful evaluation of hormonal and ovulatory menstrual cycle changes that occur with vitamin D supplementation.

Research Triangle Park, NC

The MYORISK Study (Environmental Risk Factors for the Anti-Synthetase Syndrome) The study will investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness.

Bethesda, MD

Study Overview: Myorisk Study
The Ovarian Health Study Anti-müllerian hormone (AMH) is a hormone produced in the ovaries. Researchers are investigating the possibility of developing lab assays to measure AMH in urine.

Research Triangle Park, NC

The SOLIS Study This is a phase 2a, open-label, study to evaluate the safety, tolerability, and efficacy of H01 in adults with progressive interstitial lung disease.

Research Triangle Park, NC

Women's Health Awareness Vaccine Confidence Study This is a cross-sectional population-based survey designed to characterize the impacts of the COVID-19 pandemic on women in under-studied, under-represented, and under-reported (U3) populations.

Research Triangle Park, NC

Women's Health Awareness Vaccine Confidence Study
Women’s Reproductive Health Study The broad goal of these studies is to determine the physiologic and pathophysiologic underpinnings of irregular menstrual cycles among adolescents in the early postmenarchal period.

Research Triangle Park, NC

Study Overview: Women's Reproductive Health Study

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