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| Title | Topic/Condition | Location | Join A Study |
|---|---|---|---|
| A Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics and COVID-19 Study | This study is a prospective, longitudinal, observational, single-center, exploratory study to collect samples and data that will enable explorations of the interaction between smoking, immune system characteristics and Coronavirus Disease 2019 (COVID-19). This study will collect baseline samples and data prior to COVID-19 infection required to explore these interactions prospectively. | ||
| Adult and Juvenile Myositis (Studies in the Natural History & Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies) | This study will evaluate subjects with adult- and childhood-onset myositis to learn more about the cause of the disease and associated immune system changes. | Study Overview Adult and Juvenile Myositis | |
| Biosample Repository Study | This repository will allow us to collect and store commonly utilized human biological samples (whole blood, plasma, urine, and DNA) that can be used for future laboratory procedure development, assay development, and validation, analysis of analyte degradation over time, quality control testing and exploration of scientific hypotheses. | ||
| Bisphenol A (BPA) Pharmacokinetic (PK): Controlled Exposure Study | This is a study on the controlled exposure of BPA and its effects on the body. | ||
| Black Cohosh Study | Black Cohosh is an herbal supplement that is taken by some women to treat hot flashes, cramps, or other related symptoms. Researchers are studying the health effects of black cohosh in women who have been taking the supplement for at least 3 months. Researchers are investigating whether black cohosh may affect folate and B12 levels, anemia, and metabolomics profiles. They are also investigating whether black cohosh induces genetic changes. | ||
| Blood Vessel Study | Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases. | ||
| Body Weight & Puberty Study (Investigating the Impact of Obesity on Pubertal Development in Girls) | Researchers want to find out if body weight affects when a girl starts puberty | ||
| BPA Monitoring Study in Cashiers | The study was designed to measure BPA levels before and after occupation exposure to cash register thermal paper. | ||
| Calcinosis Study | Study of Sodium Thiosulfate for Treatment of Calcinosis Associated with Juvenile and Adult Dermatomyositis | ||
| Cockroach Allergen Intervention | The purpose of this study was to determine how intensive an effective extermination must be. | ||
| Community Resiliency, Environmental Action, and Collaborations for Health (REACH) Study | This research study seeks to understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based programs for recovery and resiliency. | Study Overview: Community Resiliency, Environmental Action, and Collaborations for Health (REACH) Study | |
| Cox-2 Gene and the Immune System | The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system. | ||
| Dust Mite Reduction Study | The study delved into whether in-home test kits decreased dust mite allergen levels in homes with children who are sensitive to dust mites. | ||
| E-Cigs and Smoking Study | Researchers are trying to develop new biomarkers of tobacco smoke exposure and e-cigarette use. | ||
| Environmental Causes of Infertility | This study will use menstrual fluid as a source of endometrial cells for deriving primary cultures of stromal cells and epithelial cell organoids. | ||
| Environmental Exposure and Injury Study | This study aims to identify the interaction of host and environmental factors in the response to injury and the development of disease, and to develop better methodological tools that quantify host-environmental interactions in health and disease. | ||
| Exposure to Indoor Allergens in Day Care Facilities | The study evaluated allergen levels and their predictors in day care facilities. | ||
| Girl’s Menstrual Health Study | The broad goal of these studies is to determine the physiologic and pathophysiologic underpinnings of irregular menstrual cycles among adolescents in the early postmenarchal period. | Study Overview: Demystifying a Girl’s First Period | |
| Healthy Homes | The purpose of the study is to learn how to make homes more supportive of healthy eating and physical activity. | Emory University, Centers for Disease Control and Prevention, Southwest Georgia Cancer Coalition |
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| Immunity Cells in Blood (Innate Immunity Signal Transduction in Human Leukocytes) | To investigate the response of immune cells from the bloodstream. | ||
| Inflammatory Response to DNA Damage (Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage) | The study will look at how changes in the tumor suppressor gene p53 lead to changes in inflammation and the ability to repair DNA damage. | Study Overview: Inflammatory Response to DNA Damage | |
| Inflammatory Response to Endotoxin (Effect of Innate Immunity on the Inflammatory Response to Endotoxin) | This study will look at how differences in people’s genes may cause differences in their blood cells’ response to exposed environmental factors | Study Overview: Inflammatory Response to Endotoxin | |
| Inner-City Asthma Study (ICAS) | ICAS Study evaluates the effectiveness of two types of interventions to reduce the prevalence and severity of asthma in children. | ||
| Lung Inflammation Study | This prospective, cross-sectional study is designed to investigate the role of cytochrome P450 (CYP), including the EPHX2 and CYP2J2 proteins, in macrophage function and inflammatory response in adult volunteers who meet eligibility criteria to undergo bronchoscopy. | ||
| Metabolic Disease (Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease) | NIEHS Investigators will look at how differences in people’s genes may cause their body to respond in different ways to glucocorticoids. Glucocorticoids are hormones made by the human body that are essential for life but in excess may cause diseases such as obesity and diabetes. | ||
| Molecular Basis of Inherited Reproductive Disorders Study | During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other people may have a normal puberty but develop reproductive disorders later in life. Researchers want to study people with reproductive disorders to learn more about how these disorders may be inherited. |
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Study Overview: Inherited Reproductive Disorders Study |
| Myositis in Military Personnel (Environmental Risk Factors for the Development of Myositis in Military Personnel) | Researchers will compare military personnel with and without myositis to look for common factors that may have led to the disease. | ||
| National Health & Nutrition Examination Survey (NHANES) | NHANES allowed researchers to examine the role of diet, obesity, diabetes, and genetics in the development of allergic disease. | ||
| National Survey of Lead & Allergens in Housing (NSLAH) | NSLAH measures levels of lead in dust, soil, and paint, and the levels of various indoor allergens in floor and bedding dust. | ||
| NHALES Study (Natural History of Asthma with Longitudinal Environmental Sampling) | The study will help scientists understand how bacteria and other factors in the environment affect people who have moderate to severe asthma. | Study Overview: NHALES Asthma Study | |
| NIEHS-EPA Pilot Study of Exposure to Chemicals in Consumer Products | This study intends to test and improve the ways that studies gather data about how chemicals in products come in contact with consumers. | ||
| Nutrition and Menstrual Cycles Study (CaREFREE Study: Calorie Restriction, Environment, and Fitness: Reproductive Effects Evaluation) | This study intends to understand how nutrition, fitness, and the environment affect women's reproductive cycles. | ||
| Observation of Environment and Reproductive-Endocrine Effects | This study will investigate the relationship between environment, lifestyle, and reproductive function. | Studies Overview: Environmental Impact on Adult Hormones and Reproductive Health & Environmental Impact on Children’s H… | |
| PEGS: Personalized Environment and Genes Study | Study Overview: Personalized Environment and Genes Study (PEGS) | ||
| Plasma Study | This project will look at how oxidative stress occurs in smokers compared to non-smokers. | ||
| Polycystic Ovary Syndrome in Twin Sisters | The goal of this study is to find out whether polycystic ovary syndrome in twins is caused by genetics, environmental triggers or a combination of both. | ||
| Psoriasis Study | Researchers are studying the differences in immune response between a person with psoriasis, a person with chronic inflammatory disease and a healthy person. | ||
| Rheumatic Disorders in Siblings (Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders) | The research team will study the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, in which one has the disease and the other does not. | ||
| RSV Infection and Asthma (TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV Infection) | NIEHS scientists will explore whether there is a difference in lung cells from healthy and asthmatic participants and how these cells respond to exposure to respiratory syncytial virus (RSV), a very common virus that leads to cold-like symptoms. The study will also evaluate if a protein in lung cells called TGF-Beta increases risk of infection with RSV. | ||
| Sample Collection Registry (Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing) | Researchers are developing a registry of biologic and environmental samples with which to develop and test specific laboratory assays. | ||
| Serological Surveillance for COVID-19 in Central North Carolina | This study aims to characterize the proportion of people with detectable antibodies to SARS-CoV-2, the rate of asymptomatic carriers, the natural history of antibody titers, and association of demographic and medical factors. | ||
| Teenage Menstrual Health Study | The broad goal of this study is to determine the cause of irregular menstrual cycles in teenage girls. | Study Overview: Teenage Menstrual Health Study | |
| The Investigation of Vitamin D and Menstrual Cycles Trial: A Phase II Clinical Trial | This Phase II clinical trial translates both animal studies and human observational research into public health relevant research. We will investigate vitamin D’s influence on the hypothalamic-pituitary-ovarian axis by careful evaluation of hormonal and ovulatory menstrual cycle changes that occur with vitamin D supplementation. | ||
| The MYORISK Study (Environmental Risk Factors for the Anti-Synthetase Syndrome) | The study will investigate the genetic and environmental risk factors involved in the development of myositis, an autoimmune muscle disease that causes chronic muscle weakness. | Study Overview: Myorisk Study | |
| The Ovarian Health Study | Anti-müllerian hormone (AMH) is a hormone produced in the ovaries. Researchers are investigating the possibility of developing lab assays to measure AMH in urine. | ||
| The SOLIS Study | This is a phase 2a, open-label, study to evaluate the safety, tolerability, and efficacy of H01 in adults with progressive interstitial lung disease. | ||
| Women’s Reproductive Health Study | The broad goal of these studies is to determine the physiologic and pathophysiologic underpinnings of irregular menstrual cycles among adolescents in the early postmenarchal period. | Study Overview: Women's Reproductive Health Study |
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