Close the left navigation

Ion Channel Physiology Group

  1. Pettit, D.L., Shao, Z. & Yakel, J.L. (2001) beta-Amyloid 1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice. J. Neuroscience (Rapid Communication) 21:RC120:1-5.  [Abstract Pettit, D.L., Shao, Z. & Yakel, J.L. (2001) beta-Amyloid 1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice. J. Neuroscience (Rapid Communication) 21:RC120:1-5. ]
  2. Khiroug, S.S., Harkness, P.C., Lamb, P.W., Sudweeks, S.N., Khiroug, L., Millar, N.S., & Yakel, J.L. (2002) Rat nicotinic ACh receptor α7 and β2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. J. Physiology 540: 425-434. [Abstract Khiroug, S.S., Harkness, P.C., Lamb, P.W., Sudweeks, S.N., Khiroug, L., Millar, N.S., & Yakel, J.L. (2002) Rat nicotinic ACh receptor α7 and β2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. J. Physiology 540: 425-434.]
  3. Sudweeks, S.N., van Hooft, J.A., & Yakel, J.L. (2002) Serotonin 5-HT3 Receptors in Rat CA1 Hippocampal Interneurons: Functional and Molecular Characterization. J. Physiology 544:715-726. [Abstract Sudweeks, S.N., van Hooft, J.A., & Yakel, J.L. (2002) Serotonin 5-HT3 Receptors in Rat CA1 Hippocampal Interneurons: Functional and Molecular Characterization. J. Physiology 544:715-726.]
  4. Khiroug, L., Giniatullin, R., Klein, R.C., Fayuk, D. & Yakel, J.L. (2003) Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons. J. Neuroscience 23: 9024-9031. [Abstract Khiroug, L., Giniatullin, R., Klein, R.C., Fayuk, D. & Yakel, J.L. (2003) Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons. J. Neuroscience 23: 9024-9031.]
  5. Klein, R.C. & Yakel, J.L. (2004) Inhibition of nicotinic acetylcholine receptors by Apolipoprotein E-derived peptides in rat hippocampal slices. Neuroscience (Rapid Report) 127: 563-567.  [Abstract Klein, R.C. & Yakel, J.L. (2004) Inhibition of nicotinic acetylcholine receptors by Apolipoprotein E-derived peptides in rat hippocampal slices. Neuroscience (Rapid Report) 127: 563-567. ]
  6. Fayuk, D. & Yakel, J.L. (2004) Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Mol. Pharm. 66: 658-666. [Abstract Fayuk, D. & Yakel, J.L. (2004) Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Mol. Pharm. 66: 658-666.]
  7. Fayuk, D. & Yakel, J.L. (2005) Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurons. J. Physiology 566: 759-768. [Abstract Fayuk, D. & Yakel, J.L. (2005) Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurons. J. Physiology 566: 759-768.]
  8. Klein, R.C. & Yakel, J.L. (2005) Paired-pulse potentiation of ?7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurons. J. Physiology 568: 881-889.  [Abstract Klein, R.C. & Yakel, J.L. (2005) Paired-pulse potentiation of ?7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurons. J. Physiology 568: 881-889. ]
  9. Gay, E.A., Klein, R.C. & Yakel, J.L. (2006) Apolipoprotein E-derived peptides block ?7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharm. Exp. Ther. 316: 835-842. [Abstract Gay, E.A., Klein, R.C. & Yakel, J.L. (2006) Apolipoprotein E-derived peptides block ?7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharm. Exp. Ther. 316: 835-842.]
  10. Klein, R.C. & Yakel, J.L. (2006) Functional somato-dendritic ?7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex. J. Physiology 576: 865-872. [Abstract Klein, R.C. & Yakel, J.L. (2006) Functional somato-dendritic ?7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex. J. Physiology 576: 865-872.]
  11. Fayuk, D. & Yakel, J.L. (2007) Dendritic Ca2+ signaling due to activation of α7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. J. Physiology 582: 597-611. [Abstract Fayuk, D. & Yakel, J.L. (2007) Dendritic Ca2+ signaling due to activation of α7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. J. Physiology 582: 597-611.]
  12. Gay, E.A., Bienstock, R. J., Lamb, P.W. & Yakel, J.L. (2007) Structural determinates for apolipoproteinE–derived peptide interaction with the α7 nicotinic acetylcholine receptor. Mol. Pharm 72:838–849. [Abstract Gay, E.A., Bienstock, R. J., Lamb, P.W. & Yakel, J.L. (2007) Structural determinates for apolipoproteinE–derived peptide interaction with the α7 nicotinic acetylcholine receptor. Mol. Pharm 72:838–849.]  
  13. Gay, E.A. & Yakel, J.L. (2007) Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening. J. Physiology (Topical Review) 584: 727-733. [Abstract Gay, E.A. & Yakel, J.L. (2007) Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening. J. Physiology (Topical Review) 584: 727-733.]  
  14. Fayuk, D., & Yakel, J.L. (2007) Dendritic Ca2+ signaling due to activation of a7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. The Journal of Physiology Pt 2:597-611. [Abstract Fayuk, D., & Yakel, J.L. (2007) Dendritic Ca2+ signaling due to activation of a7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. The Journal of Physiology Pt 2:597-611.]  
  15. Gay EA, Klein RC, Melton MA, Blackshear PJ, Yakel JL. Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. J Pharmacol Exp Ther. 2008 Dec;327(3):884-890. Epub 2008 Sep 23. [Abstract Gay EA, Klein RC, Melton MA, Blackshear PJ, Yakel JL. Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. J Pharmacol Exp Ther. 2008 Dec;327(3):884-890. Epub 2008 Sep 23.] [Full Text Gay EA, Klein RC, Melton MA, Blackshear PJ, Yakel JL. Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. J Pharmacol Exp Ther. 2008 Dec;327(3):884-890. Epub 2008 Sep 23.]  
  16. Shen, J.X., Tu, B., & Yakel, J.L. (2009) Inhibition of alpha7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurons in slices. The Journal of physiology 587(Pt 5):1033-1042. [Abstract Shen, J.X., Tu, B., & Yakel, J.L. (2009) Inhibition of alpha7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurons in slices. The Journal of physiology 587(Pt 5):1033-1042.]  
  17. Eddins, D., Klein, R.C., Yakel, J.L., & Levin, E.D. (2009) Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment. Brain Res. Bull. 79:111-115. [Abstract Eddins, D., Klein, R.C., Yakel, J.L., & Levin, E.D. (2009) Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment. Brain Res. Bull. 79:111-115.]  
  18. Tu, B., Gu, Z., Shen, J., Lamb, P.W., & Yakel, J.L. (2009) Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. J. Neuroscience 29:10436 –10448 [Abstract Tu, B., Gu, Z., Shen, J., Lamb, P.W., & Yakel, J.L. (2009) Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. J. Neuroscience 29:10436 –10448]  
  19. Shen, J.X., & Yakel, J.L. (2009) Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system. Acta Pharmacol Sin. 30:673-680. [Abstract Shen, J.X., & Yakel, J.L. (2009) Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system. Acta Pharmacol Sin. 30:673-680.]  
  20. Timofeeva, O.A., Eddins, D., Yakel, J.L., Blackshear, P.J., & Levin, E.D. (2010) Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze. Brain Res. 1308:147-152. [Abstract Timofeeva, O.A., Eddins, D., Yakel, J.L., Blackshear, P.J., & Levin, E.D. (2010) Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze. Brain Res. 1308:147-152. ]   
  21. Yakel, J.L. (2010) Gating of nicotinic ACh receptors: latest insights into ligand binding and function. J. Physiology 588:597-602. [Abstract Yakel, J.L. (2010) Gating of nicotinic ACh receptors: latest insights into ligand binding and function. J. Physiology 588:597-602.]  
  22. McCormack, T., Petrovich, R.M., Mercier, K.A., DeRose, E.F., Cuneo, M.J., Williams, J., Johnson, K.L., Lamb, P.W., London, R.E., & Yakel, J.L. (2010) Identification and Functional Characterization of a Novel Acetylcholine-binding Protein from the Marine Annelid Capitella teleta. Biochemistry 49:2279-2287. [Abstract McCormack, T., Petrovich, R.M., Mercier, K.A., DeRose, E.F., Cuneo, M.J., Williams, J., Johnson, K.L., Lamb, P.W., London, R.E., & Yakel, J.L. (2010) Identification and Functional Characterization of a Novel Acetylcholine-binding Protein from the Marine Annelid Capitella teleta. Biochemistry 49:2279-2287.]  
  23. Seipel, A.T., & Yakel, J.L. (2010) The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor. J. Neurochemistry: in press. [Abstract Seipel, A.T., & Yakel, J.L. (2010) The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor. J. Neurochemistry: in press.]  
  24. Seipel, A.T., & Yakel, J.L. (2010) The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the alpha7 nicotinic receptor. Journal of Neurochemistry 114(6):1659-1666. [Abstract Seipel, A.T., & Yakel, J.L. (2010) The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the alpha7 nicotinic receptor. Journal of Neurochemistry 114(6):1659-1666.]  
  25. McCormack, T.J., Melis, C., Colón, J., Gay, E.A., Mike, A., Karoly, R., Lamb, P.W., Molteni, C., & Yakel, J.L. (2010) Rapid Desensitization of the Rat {alpha}7 nAChR is Facilitated by the Presence of a Proline Residue in the Outer {beta}-Sheet. The Journal of physiology 588(Pt 22):4415-4429. [Abstract McCormack, T.J., Melis, C., Colón, J., Gay, E.A., Mike, A., Karoly, R., Lamb, P.W., Molteni, C., & Yakel, J.L. (2010) Rapid Desensitization of the Rat {alpha}7 nAChR is Facilitated by the Presence of a Proline Residue in the Outer {beta}-Sheet. The Journal of physiology 588(Pt 22):4415-4429.]   
  26. Brams, M., Gay, EA, Saez, C.S., Guskov, A., van Elk, R., van der Schors, R.C., Peigneur, S., Tytgat, J., Strelkov, S.V., Smit, A.B., Yakel, J.L.,& Ulens, C. (2011) Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein. The Journal of biological chemistry 286(6):4420-4428. [Abstract Brams, M., Gay, EA, Saez, C.S., Guskov, A., van Elk, R., van der Schors, R.C., Peigneur, S., Tytgat, J., Strelkov, S.V., Smit, A.B., Yakel, J.L.,& Ulens, C. (2011) Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein. The Journal of biological chemistry 286(6):4420-4428.]  
  27. Brams, M., Pandya, A., Kuzmin, D., van Elk, R., Krijnen, L., Yakel, J.L., Tsetlin, V., Smit, A.B., Ulens, C. (2011) A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. PLoS biology 9(3):e1001034. [Abstract Brams, M., Pandya, A., Kuzmin, D., van Elk, R., Krijnen, L., Yakel, J.L., Tsetlin, V., Smit, A.B., Ulens, C. (2011) A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. PLoS biology 9(3):e1001034.]  
  28. Colon Saez, J.O., Yakel, J.L. (2011) The 7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane.The Journal of physiology 589(Pt 13):3163-3174. [Abstract Colon Saez, J.O., Yakel, J.L. (2011) The 7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane.The Journal of physiology 589(Pt 13):3163-3174.]
  29. Pandya, A., & Yakel, J.L. (2011) Allosteric modulator Desformylflustrabromine relieves the inhibition of alpha2beta2 and alpha4beta2 nicotinic acetylcholine receptors by beta-amyloid(1-42) peptide. Journal of molecular neuroscience  45(1): 42-47. [Abstract Pandya, A., & Yakel, J.L. (2011) Allosteric modulator Desformylflustrabromine relieves the inhibition of alpha2beta2 and alpha4beta2 nicotinic acetylcholine receptors by beta-amyloid(1-42) peptide. Journal of molecular neuroscience  45(1): 42-47.]  
  30. Pandya, A., & Yakel, J.L. (2011) Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors. Biochemical pharmacology  82(9): 952-958. [Abstract Pandya, A., & Yakel, J.L. (2011) Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors. Biochemical pharmacology  82(9): 952-958.]  
  31. Gu, Z., & Yakel, J.L. (2011) Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron  71(1): 155-165. [Abstract Gu, Z., & Yakel, J.L. (2011) Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron  71(1): 155-165.]  
  32. Billen B., Spurny R., Brams M., van Elk R., Valera-Kummer S., Yakel J.L., Voets T., Bertrand D., Smit A.B., Ulens C. (2012) Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein. Proceedings of the National Academy of Sciences of the United States of America 109(23):9173-8. [Abstract Billen B., Spurny R., Brams M., van Elk R., Valera-Kummer S., Yakel J.L., Voets T., Bertrand D., Smit A.B., Ulens C. (2012) Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein. Proceedings of the National Academy of Sciences of the United States of America 109(23):9173-8.]
  33. Gu Z, Lamb PW, Yakel JL. (2012) Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity. Journal of Neuroscience 32(36):12337-48. [Abstract Gu Z, Lamb PW, Yakel JL. (2012) Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity. Journal of Neuroscience 32(36):12337-48.]
  34. Shen JX, Yakel JL. Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices. Journal of molecular neuroscience 2012 48(1):14-21 [Abstract Shen JX, Yakel JL. Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices. Journal of molecular neuroscience 2012 48(1):14-21]
  35. Pandya A, Yakel JL. (2013) Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist. Neuropharmacology 70:35-42.  [Abstract Pandya A, Yakel JL. (2013) Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist. Neuropharmacology 70:35-42. ]
  36. Yakel JL. (2013) Cholinergic Receptors: Functional Role of Nicotinic ACh Receptors in Brain Circuits and Disease. Pflugers Archiv: European journal of physiology 465(4):441-450. [Abstract Yakel JL. (2013) Cholinergic Receptors: Functional Role of Nicotinic ACh Receptors in Brain Circuits and Disease. Pflugers Archiv: European journal of physiology 465(4):441-450.]
  37. Pandya AA, Yakel JL. 2013. Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies. Biochemical pharmacology 86(8):1054-1062. [Abstract Pandya AA, Yakel JL. 2013. Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies. Biochemical pharmacology 86(8):1054-1062.]
  38. Cheng Q, Yakel JL. 2014. Presynaptic α7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation. Journal of Neuroscience 34(1):124-33. [Abstract Cheng Q, Yakel JL. 2014. Presynaptic α7 Nicotinic Acetylcholine Receptors Enhance Hippocampal Mossy Fiber Glutamatergic Transmission via PKA Activation. Journal of Neuroscience 34(1):124-33.]
  39. Colón-Sáez JO, Yakel JL. 2014. A mutation in the extracellular domain of the a7 nAChR reduces calcium permeability. Pflugers Archiv: European journal of physiology 2014 466(8):1571-1579. [Abstract Colón-Sáez JO, Yakel JL. 2014. A mutation in the extracellular domain of the a7 nAChR reduces calcium permeability. Pflugers Archiv: European journal of physiology 2014 466(8):1571-1579.]
  40. Hernandez C.M., Cortez I., Gu Z., Colón-Sáez J.O., Lamb P.W., Wakamiya M., Yakel J.L., Dineley K.T.. (2014) Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches. The Journal of physiology 592 (Pt 15):3201-2314.  [Abstract Hernandez C.M., Cortez I., Gu Z., Colón-Sáez J.O., Lamb P.W., Wakamiya M., Yakel J.L., Dineley K.T.. (2014) Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches. The Journal of physiology 592 (Pt 15):3201-2314. ]
  41. Cheng Q, Yakel JL. 2015. The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus. Biochemical pharmacology 97(4):439-444. [Abstract Cheng Q, Yakel JL. 2015. The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus. Biochemical pharmacology 97(4):439-444.]
  42. Wu J, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL. 2016. Heteromeric α7β2 nicotinic acetylcholine receptors in the brain. Trends in Pharmacological Sciences 37(7):562-574. [Abstract Wu J, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL. 2016. Heteromeric α7β2 nicotinic acetylcholine receptors in the brain. Trends in Pharmacological Sciences 37(7):562-574.]
  43. Gu Z, Yakel JL. 2017. Inducing theta oscillation in the entorhinal hippocampal network in vitro. Brain Structure and Function 222(2):943-955. [Abstract Gu Z, Yakel JL. 2017. Inducing theta oscillation in the entorhinal hippocampal network in vitro. Brain Structure and Function 222(2):943-955.]
  44. Damborsky JC, Smith KG, Jensen P, Yakel JL. 2017. Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin. Brain Structure and Function 222(3):1385-1400. [Abstract Damborsky JC, Smith KG, Jensen P, Yakel JL. 2017. Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin. Brain Structure and Function 222(3):1385-1400.]
  45. Gu Z, Alexander GM, Dudek SM, Yakel JL. 2017. Hippocampus and entorhinal cortex recruit cholinergic and NMDA receptors separately to generate hippocampal theta oscillations. Cell Reports 21(12):35-85-3595. [Abstract Gu Z, Alexander GM, Dudek SM, Yakel JL. 2017. Hippocampus and entorhinal cortex recruit cholinergic and NMDA receptors separately to generate hippocampal theta oscillations. Cell Reports 21(12):35-85-3595.]
  46. Otto SL, Yakel JL. 2018. The α7 nicotinic acetylcholine receptors regulate hippocampal adult-neurogenesis in a sexually dimorphic fashion. Brain structure & function 224(2):829-846. [Abstract Otto SL, Yakel JL. 2018. The α7 nicotinic acetylcholine receptors regulate hippocampal adult-neurogenesis in a sexually dimorphic fashion. Brain structure & function 224(2):829-846.] 
  47. Haam J, Zhou J, Cui G, Yakel JL. 2018. Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons. Proceedings of the National Academy of Sciences of the United States of America 115(8):E1886-E1895. [Abstract Haam J, Zhou J, Cui G, Yakel JL. 2018. Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons. Proceedings of the National Academy of Sciences of the United States of America 115(8):E1886-E1895.]
  48. Fitch RW, Snider BB, Zhou Q, Foxman BM, Pandya AA. Yakel JL, Olson TT, Al-Muhtasib N, Xiao Y, Welch KD, Panter KE. 2018. Absolute configuration and pharmacology of the poison frog alkaloid phantasmidine. Journal of Natural Products 81(4):1029-1035. [Abstract Fitch RW, Snider BB, Zhou Q, Foxman BM, Pandya AA. Yakel JL, Olson TT, Al-Muhtasib N, Xiao Y, Welch KD, Panter KE. 2018. Absolute configuration and pharmacology of the poison frog alkaloid phantasmidine. Journal of Natural Products 81(4):1029-1035.]
  49. Chen YW, Das M, Oyarzabal EA, Cheng Q, Plummer NW, Smith KG, Jones GK, Malawsky D, Yakel JL, Shih YI, Jensen P. 2018. Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses. Molecular Psychiatry; doi:10.1038/s41380-018-0245-8 [Online 13 September 2018]. [Abstract Chen YW, Das M, Oyarzabal EA, Cheng Q, Plummer NW, Smith KG, Jones GK, Malawsky D, Yakel JL, Shih YI, Jensen P. 2018. Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses. Molecular Psychiatry; doi:10.1038/s41380-018-0245-8 [Online 13 September 2018].]
  50. Zhao Z, Wang Y, Zhou R, Li Y, Gao Y, Tu D, Wilson B, Song S, Feng J, Hong JS, Yakel JL. 2020. A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration. J Neuroinflammation 17(1):64. [Abstract Zhao Z, Wang Y, Zhou R, Li Y, Gao Y, Tu D, Wilson B, Song S, Feng J, Hong JS, Yakel JL. 2020. A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration. J Neuroinflammation 17(1):64.]
  51. Gu Z, Smith KG, Alexander GM, Guerreiro I, Dudek SM, Gutkin B, Jensen P, Yakel JL. 2020. Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice. Cell Rep; doi: 10.1016/j.celrep.2020.107740 [Online 9 June 2020]. [Abstract Gu Z, Smith KG, Alexander GM, Guerreiro I, Dudek SM, Gutkin B, Jensen P, Yakel JL. 2020. Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice. Cell Rep; doi: 10.1016/j.celrep.2020.107740 [Online 9 June 2020].]
  52. Nacer SA, Letsinger AC, Otto S, DeFilipp JS, Nikolova VD, Riddick NV, Stevanovic KD, Cushman JD, Yakel JL. 2021. Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior. Brain Struct Funct; doi: 10.1007/s00429-020-02179-3 [Online 4 January 2021]. [Abstract Nacer SA, Letsinger AC, Otto S, DeFilipp JS, Nikolova VD, Riddick NV, Stevanovic KD, Cushman JD, Yakel JL. 2021. Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior. Brain Struct Funct; doi: 10.1007/s00429-020-02179-3 [Online 4 January 2021].]
  53. Damborsky JC, Yakel JL. 2021. Regulation of hippocamposeptal input within the medial septum/diagonal band of Broca. Neuropharmacology 191:108589. [Abstract Damborsky JC, Yakel JL. 2021. Regulation of hippocamposeptal input within the medial septum/diagonal band of Broca. Neuropharmacology 191:108589.]
  54. Cheng Q, Lamb P, Stevanovic K, Bernstein BJ, Fry SA, Cushman JD, Yakel JL. 2021. Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus in vitro and in vivo. J Physiol. 599(20):4687-4704. doi: 10.1113/JP280505. PMID: 34487349. [Abstract]
  55. Letsinger AC, Gu Z, Yakel JL. 2022. α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity. Trends Neurosci. 45(2):145-157. doi: 10.1016/j.tins.2021.11.006. [Abstract Letsinger AC, Gu Z, Yakel JL. 2022. α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity. Trends Neurosci. 45(2):145-157. doi: 10.1016/j.tins.2021.11.006.]
  56. Gu Z, Yakel JL. 2022. Cholinergic regulation of hippocampal theta rhythm. Biomedicines 10(4):745. [Abstract Gu Z, Yakel JL. 2022. Cholinergic regulation of hippocampal theta rhythm. Biomedicines 10(4):745.] [Full Text Gu Z, Yakel JL. 2022. Cholinergic regulation of hippocampal theta rhythm. Biomedicines 10(4):745.]
  57. Guerreiro I, Gu Z, Yakel JL, Gutkin BS. 2022. Recurring Cholinergic Inputs Induce Local Hippocampal Plasticity through Feedforward Disinhibition. eNeuro. 9(5):ENEURO.0389-21.2022. doi: 10.1523/ENEURO.0389-21.2022. PMID: 36028329. [Abstract]
  58. Goral RO, Harper KM, Bernstein BJ, Fry SA, Lamb PW, Moy SS, Cushman JD, Yakel JL. 2022. Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions. Front Behav Neurosci. 16:1067409. doi: 10.3389/fnbeh.2022.1067409. PMID: 36505727. [Abstract]
  59. Letsinger AC, Ward JM, Fannin RD, Mahapatra D, Bridge MF, Sills RC, Gerrish KE, Yakel JL. Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity. Sci Rep. 13(1):2042. doi: 10.1038/s41598-023-29118-6. PMID: 36739463. [Abstract]
  60. Letsinger AC, Nacer SA, Stevanovic KD, Larson GJ, DeFilipp JS, Cushman JD, Yakel JL. Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only. Front Neurosci. 17:1244118. doi: 10.3389/fnins.2023.1244118. PMID: 37746145. [Abstract]
  61. Haam J, Gunin S, Wilson L, Fry S, Bernstein B, Thomson E, Noblet H, Cushman J, Yakel JL. Entorhinal cortical delta oscillations drive memory consolidation. Cell Rep. 42(10):113267. doi: 10.1016/j.celrep.2023.113267. PMID: 37838945. [Abstract]
  62. Gu Z, Stevanovic KD, Cushman JD, Yakel JL. 2024. Cholinergic-Sensitive Theta Oscillations in Memory Encoding in Mice. J Neurosci. 44(12):e1313232024. doi: 10.1523/JNEUROSCI.1313-23.2024. PMID: 38331584. [Abstract]