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Mechanisms of Genome Dynamics Group

  1. Zhang T, Joubert P, Ansari-Pour N, Zhao W, Hoang PH, Lokanga R, Moye AL, Rosenbaum J, Gonzalez-Perez A, Martínez-Jiménez F, Castro A, Muscarella LA, Hofman P, Consonni D, Pesatori AC, Kebede M, Li M, Gould Rothberg BE, Peneva I, Schabath MB, Poeta ML, Costantini M, Hirsch D, Heselmeyer-Haddad K, Hutchinson A, Olanich M, Lawrence SM, Lenz P, Duggan M, Bhawsar PMS, Sang J, Kim J, Mendoza L, Saini N, Klimczak LJ, Islam SMA, Otlu B, Khandekar A, Cole N, Stewart DR, Choi J, Brown KM, Caporaso NE, Wilson SH, Pommier Y, Lan Q, Rothman N, Almeida JS, Carter H, Ried T, Kim CF, Lopez-Bigas N, Garcia-Closas M, Shi J, Bossé Y, Zhu B, Gordenin DA, Alexandrov LB, Chanock SJ, Wedge DC, Landi MT. 2021. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genet 53(9):1348-1359. [Abstract Zhang T, Joubert P, Ansari-Pour N, Zhao W, Hoang PH, Lokanga R, Moye AL, Rosenbaum J, Gonzalez-Perez A, Martínez-Jiménez F, Castro A, Muscarella LA, Hofman P, Consonni D, Pesatori AC, Kebede M, Li M, Gould Rothberg BE, Peneva I, Schabath MB, Poeta ML, Costantini M, Hirsch D, Heselmeyer-Haddad K, Hutchinson A, Olanich M, Lawrence SM, Lenz P, Duggan M, Bhawsar PMS, Sang J, Kim J, Mendoza L, Saini N, Klimczak LJ, Islam SMA, Otlu B, Khandekar A, Cole N, Stewart DR, Choi J, Brown KM, Caporaso NE, Wilson SH, Pommier Y, Lan Q, Rothman N, Almeida JS, Carter H, Ried T, Kim CF, Lopez-Bigas N, Garcia-Closas M, Shi J, Bossé Y, Zhu B, Gordenin DA, Alexandrov LB, Chanock SJ, Wedge DC, Landi MT. 2021. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genet 53(9):1348-1359.]
  2. Kockler ZW, Gordenin DA. 2021. From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution. Cells 10(6):1557. [Abstract Kockler ZW, Gordenin DA. 2021. From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution. Cells 10(6):1557.]
  3. Saini N, Giacobone CK, Klimczak LJ, Papas BN, Burkholder AB, Li JL, Fargo DC, Bai R, Gerrish K, Innes CL, Schurman SH, Gordenin DA. 2021. UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. PLoS Genet; doi: 10.1371/journal.pgen.1009302 [Online 14 January 2021]. [Abstract Saini N, Giacobone CK, Klimczak LJ, Papas BN, Burkholder AB, Li JL, Fargo DC, Bai R, Gerrish K, Innes CL, Schurman SH, Gordenin DA. 2021. UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. PLoS Genet; doi: 10.1371/journal.pgen.1009302 [Online 14 January 2021].]
  4. Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge DC, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ. 2020. Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-smokers. Am J Epidemiol; doi: 10.1093/aje/kwaa234 [Online 28 October 2020]. [Abstract Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge DC, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ. 2020. Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-smokers. Am J Epidemiol; doi: 10.1093/aje/kwaa234 [Online 28 October 2020].]
  5. Akdemir KC, Le VT, Kim JM, Killcoyne S, King DA, Lin YP, Tian Y, Inoue A, Amin SB, Robinson FS, Nimmakayalu M, Herrera RE, Lynn EJ, Chan K, Seth S, Klimczak LJ, Gerstung M, Gordenin DA, O'Brien J, Li L, Deribe YL, Verhaak RG, Campbell PJ, Fitzgerald R, Morrison AJ, Dixon JR, PA Futreal. 2020. Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure. Nat Genet; doi: 10.1038/s41588-020-0708-0 [Online 5 October 2020]. [Abstract Akdemir KC, Le VT, Kim JM, Killcoyne S, King DA, Lin YP, Tian Y, Inoue A, Amin SB, Robinson FS, Nimmakayalu M, Herrera RE, Lynn EJ, Chan K, Seth S, Klimczak LJ, Gerstung M, Gordenin DA, O'Brien J, Li L, Deribe YL, Verhaak RG, Campbell PJ, Fitzgerald R, Morrison AJ, Dixon JR, PA Futreal. 2020. Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure. Nat Genet; doi: 10.1038/s41588-020-0708-0 [Online 5 October 2020].]
  6. Klimczak LJ, Randall TA, Saini N, Li JL, Gordenin DA. 2020. Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic. PLoS One; doi: 10.1371/journal.pone.0237689 [Online 2 October 2020]. [Abstract Klimczak LJ, Randall TA, Saini N, Li JL, Gordenin DA. 2020. Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic. PLoS One; doi: 10.1371/journal.pone.0237689 [Online 2 October 2020].]
  7. Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. 2020. APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. Nat Genet; doi: 10.1038/s41588-020-0667-5 [Online 27 July 2020]. [Abstract Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. 2020. APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. Nat Genet; doi: 10.1038/s41588-020-0667-5 [Online 27 July 2020].] 
  8. Saini N, Gordenin DA. 2020. Hypermutation in Single-Stranded DNA. DNA Repair (Amst); doi: 10.1016/j.dnarep.2020.102868 [Online 18 May 2020]. [Abstract Saini N, Gordenin DA. 2020. Hypermutation in Single-Stranded DNA. DNA Repair (Amst); doi: 10.1016/j.dnarep.2020.102868 [Online 18 May 2020].]
  9. Sui Y, Qi L, Zhang K, Saini N, Klimczak LJ, Sakofsky CJ, Gordenin DA, Petes TD, Zheng DQ. 2020. Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. Proc Natl Acad Sci U S A 117(17):9440-9450. [Abstract Sui Y, Qi L, Zhang K, Saini N, Klimczak LJ, Sakofsky CJ, Gordenin DA, Petes TD, Zheng DQ. 2020. Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. Proc Natl Acad Sci U S A 117(17):9440-9450.] 
  10. Saini N, Sterling JF, Sakofsky CJ, Giacobone CK, Klimczak LJ, Burkholder, Malc EP, Mieczkowski PA, Gordenin DA. 2020. Mutation signatures specific to DNA alkylating agents in yeast and cancers. Nucleic Acids Res 48(7):3692-3707. [Abstract Saini N, Sterling JF, Sakofsky CJ, Giacobone CK, Klimczak LJ, Burkholder, Malc EP, Mieczkowski PA, Gordenin DA. 2020. Mutation signatures specific to DNA alkylating agents in yeast and cancers. Nucleic Acids Res 48(7):3692-3707.]
  11. Alexandrov LB, Kim J, Haradhvala N, Huang MN, Ng AWT, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler D, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium. 2020. The repertoire of mutational signatures in human cancer. Nature 578(7793):94-101. [Abstract Alexandrov LB, Kim J, Haradhvala N, Huang MN, Ng AWT, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler D, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium. 2020. The repertoire of mutational signatures in human cancer. Nature 578(7793):94-101.] 
  12. Cortes-Ciriano I, Lee JK, Xi R, Jain D, Jung YL, Yang L, Gordenin DA, Klimczak LJ, Zhang CZ, Pellman DS, PCAWG Structural Variation Working Group, Park PJ, PCAWG Consortium. 2020. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet doi: 10.1038/s41588-019-0576-7 [Online 5 February 2020]. [Abstract Cortes-Ciriano I, Lee JK, Xi R, Jain D, Jung YL, Yang L, Gordenin DA, Klimczak LJ, Zhang CZ, Pellman DS, PCAWG Structural Variation Working Group, Park PJ, PCAWG Consortium. 2020. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet doi: 10.1038/s41588-019-0576-7 [Online 5 February 2020].] 
  13. Perelygina L, Chen M, Suppiah S, Adebayo A, Abernathy E, Dorsey M, Bercovitch L, Paris K, White K, Krol A, Dhossche J, Torshin I, Saini N, Klimczak LJ, Gordenin DA, Zharkikh A, Plotkin S, Sullivan KE, Icenogle J. 2019. Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies. PLoS Pathog 15(10):e1008080. [Abstract Perelygina L, Chen M, Suppiah S, Adebayo A, Abernathy E, Dorsey M, Bercovitch L, Paris K, White K, Krol A, Dhossche J, Torshin I, Saini N, Klimczak LJ, Gordenin DA, Zharkikh A, Plotkin S, Sullivan KE, Icenogle J. 2019. Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies. PLoS Pathog 15(10):e1008080.]
  14. Sakofsky CJ, Saini N, Klimczak LJ, Chan K, Malc EP, Mieczkowski PA, Burkholder AB, Fargo D, Gordenin DA. Repair of Multiple Simultaneous Double-strand Breaks Causes Bursts of Genome-wide Clustered Hypermutation. PLoS Biol 2019 17(9):e3000464. [Abstract Sakofsky CJ, Saini N, Klimczak LJ, Chan K, Malc EP, Mieczkowski PA, Burkholder AB, Fargo D, Gordenin DA. Repair of Multiple Simultaneous Double-strand Breaks Causes Bursts of Genome-wide Clustered Hypermutation. PLoS Biol 2019 17(9):e3000464.]
  15. Gordenin DA, Mironova LN. Michael Ter-Avanesyan (1949-2018) - Advent of the Scientist. Prion 2019 13(1):33-36. [Abstract Gordenin DA, Mironova LN. Michael Ter-Avanesyan (1949-2018) - Advent of the Scientist. Prion 2019 13(1):33-36.]
  16. Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A. Guidelines for DNA Recombination and Repair Studies: Cellular Assays of DNA Repair Pathways. Microbial Cell 2019 6(1):1-64. [Abstract Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A. Guidelines for DNA Recombination and Repair Studies: Cellular Assays of DNA Repair Pathways. Microbial Cell 2019 6(1):1-64.]
  17. Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz EM, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J. Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer cell 2018 43(6):996-1011.e8. [Abstract Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz EM, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J. Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer cell 2018 43(6):996-1011.e8.]
  18. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell 2017 171(3):540-556.e25. [Abstract Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell 2017 171(3):540-556.e25.] 
  19. Burk RD, 95 authors, Gordenin DA, Chan K, Roberts SR, Klimczak LJ, 145 authors, Mutch D. Integrated genomic and molecular characterization of cervical cancer. Nature 2017 ():-. [Abstract Burk RD, 95 authors, Gordenin DA, Chan K, Roberts SR, Klimczak LJ, 145 authors, Mutch D. Integrated genomic and molecular characterization of cervical cancer. Nature 2017 ():-.]
  20. Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. The impact of environmental and endogenous damage on somatic mutation load in human skin fibroblasts. PLoS genetics 2016 12(10):-. [Abstract Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. The impact of environmental and endogenous damage on somatic mutation load in human skin fibroblasts. PLoS genetics 2016 12(10):-.]
  21. Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell reports 2015 13(6):1103-1109. [Abstract Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell reports 2015 13(6):1103-1109.]
  22. Chan K, Gordenin DA. Clusters of Multiple Mutations: Incidence and Molecular Mechanisms. Annual review of genetics 2015 49():243-267. [Abstract Chan K, Gordenin DA. Clusters of Multiple Mutations: Incidence and Molecular Mechanisms. Annual review of genetics 2015 49():243-267.]
  23. Chan K, Roberts SA, Klimczak LJ, Sterling JF, Saini N, Malc EP, Kim J, Kwiatkowski DJ, Fargo DC, Mieczkowski PA, Getz G, Gordenin DA. An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers. Nat Genet. 2015 Sep;47(9):1067-72. doi: 10.1038/ng.3378. Epub 2015 Aug 10. PubMed PMID: 26258849.
  24. Davis C, 112 authors, Gordenin DA, Fargo D, Klimczak LJ, Roberts SA, 102 authors, Creighton C. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer cell 2014 26(3):319-330. [Abstract Davis C, 112 authors, Gordenin DA, Fargo D, Klimczak LJ, Roberts SA, 102 authors, Creighton C. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer cell 2014 26(3):319-330.]
  25. Roberts SA, Gordenin DA. Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness. BioEssays: news and reviews in molecular, cellular and developmental biology 2014 ():-.
    [Abstract Roberts SA, Gordenin DA. Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness. BioEssays: news and reviews in molecular, cellular and developmental biology 2014 ():-.
    ]
  26. Robert SA, Gordenin DA. 2014. Clustered Mutations in Human Cancer. Inc. eLS. John Wiley & Sons, Ltd; Chichester.
  27. Lujan SA, Clausen AR, Clark AB, MacAlpine HK, MacAlpine DM, Malc EP, Mieczkowski PA, Burkholder AB, Fargo DC, Gordenin DA, Kunkel TA. Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. Genome research 2014 24(11):1751-1764. [Abstract Lujan SA, Clausen AR, Clark AB, MacAlpine HK, MacAlpine DM, Malc EP, Mieczkowski PA, Burkholder AB, Fargo DC, Gordenin DA, Kunkel TA. Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. Genome research 2014 24(11):1751-1764.]
  28. Roberts, SA and DA Gordenin. Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer 2014 14(12): 786-800. [Abstract Roberts, SA and DA Gordenin. Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer 2014 14(12): 786-800.]
  29. Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648. [Abstract Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648.]
  30. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014 507(7492):315-322. [Abstract Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014 507(7492):315-322.]
  31. Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889. [Abstract Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889.]
  32. Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013. [Abstract Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013.]
  33. Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. 2012. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 8(12):e1003149. [Abstract Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. 2012. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 8(12):e1003149.]
  34. Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. 2012.  Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell 46(4):424-435. [Abstract Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. 2012.  Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell 46(4):424-435.]
  35. Burch LH, Yang Y, Sterling JF, Roberts S, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA. 2011. Damage-Induced Localized Hypermutability. Cell Cycle (Georgetown, Tex.) 10(7): 1073-1085. [Abstract Burch LH, Yang Y, Sterling JF, Roberts S, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA. 2011. Damage-Induced Localized Hypermutability. Cell Cycle (Georgetown, Tex.) 10(7): 1073-1085.]
  36. Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264. [Abstract Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264.]
  37. Ma W, Resnick MA, Gordenin DA. 2008. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acid Res 36(6): 1836-1846. [Abstract Ma W, Resnick MA, Gordenin DA. 2008. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acid Res 36(6): 1836-1846.]
  38. Jin YH, Garg P, Stith CM, Al-Refai H, Sterling JF, Murray LJ, Kunkel TA, Resnick MA, Burgers PM, Gordenin DA. 2005. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol 25(1): 461-471. [Abstract Jin YH, Garg P, Stith CM, Al-Refai H, Sterling JF, Murray LJ, Kunkel TA, Resnick MA, Burgers PM, Gordenin DA. 2005. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol 25(1): 461-471.]

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