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Mechanistic Toxicology Branch

Paul E. Dunlap
Paul E. Dunlap
Biologist
Tel 984-287-4222
[email protected]
P.O. Box 12233
Mail Drop E1-05
Durham, NC 27709

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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Paul Dunlap is a biologist in the NIEHS Division of Translational Toxicology. He participates in the chemical screening in liver and kidney in vitro systems.

Since 2016, Dunlap and the rest of the Mechanistic Toxicology Branch has used liver as an alternative model in high-throughput toxicological screening. Most recently, Dunlap has participated in studies on the toxicological effects of PCBs, glyphosate, botanical supplements, PBZTs, and among other chemicals. More recently he and the rest of the group has developed new techniques using 3D in vitro spheroid models to study toxic effects.

Dunlap received his B.A. in biology from Earlham College in Richmond, Indiana in 1986 and he completed graduate studies at the University of Colorado-Boulder in 2002. Before joining NIEHS in 2006, he worked in the laboratory of Jonathan Freedman, Ph.D. at Duke University's Integrated Toxicology Program.

Selected Publications

  1. Jin YH, Dunlap PE, McBride SJ, Al-Refai H, Bushel PR, Freedman JH. Global transcriptome and deletome profiles of yeast exposed to transition metals. PLoS Genet. 2008 Apr 25;4(4):e1000053.
  2. Alper S, Laws R, Lackford B, Boyd WA, Dunlap P, Freedman JH, Schwartz DA. 2008. Identification of innate immunity genes and pathways using a comparative genomics approach. Proceedings of the National Academy of Sciences of the United States of America, 105(19):7061-7021. [Abstract Alper S, Laws R, Lackford B, Boyd WA, Dunlap P, Freedman JH, Schwartz DA. 2008. Identification of innate immunity genes and pathways using a comparative genomics approach. Proceedings of the National Academy of Sciences of the United States of America, 105(19):7061-7021.]