Mechanistic Toxicology Branch
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Paul E. Dunlap
Biologist -
Tel 984-287-4222
[email protected] -
P.O. Box 12233Mail Drop E1-05Durham, NC 27709
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Paul Dunlap is a biologist in the NIEHS Division of Translational Toxicology. He participates in the chemical screening in liver and kidney in vitro systems.
Since 2016, Dunlap and the rest of the Mechanistic Toxicology Branch has used liver as an alternative model in high-throughput toxicological screening. Most recently, Dunlap has participated in studies on the toxicological effects of PCBs, glyphosate, botanical supplements, PBZTs, and among other chemicals. More recently he and the rest of the group has developed new techniques using 3D in vitro spheroid models to study toxic effects.
Dunlap received his B.A. in biology from Earlham College in Richmond, Indiana in 1986 and he completed graduate studies at the University of Colorado-Boulder in 2002. Before joining NIEHS in 2006, he worked in the laboratory of Jonathan Freedman, Ph.D. at Duke University's Integrated Toxicology Program.
Recent Publications
- Merrick B, Martin N, Brooks A, Foley J, Dunlap P, Ramaiahgari S, Fannin R, Gerrish K. Insights into Repeated Renal Injury Using RNA-Seq with Two New RPTEC Cell Lines. International journal of molecular sciences. 2023 Sep 18;24(18):. [ AbstractMerrick B, Martin N, Brooks A, Foley J, Dunlap P, Ramaiahgari S, Fannin R, Gerrish K. Insights into Repeated Renal Injury Using RNA-Seq with Two New RPTEC Cell Lines. International journal of molecular sciences. 2023 Sep 18 ]
- Crizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27;181(2):175-186. [ AbstractCrizer D, Ramaiahgari S, Ferguson S, Rice J, Dunlap P, Sipes N, Auerbach S, Merrick B, DeVito M. Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models. Toxicological sciences : an official journal of the Society of Toxicology. 2021 May 27 ]
- Ryan K, Huang M, Ferguson S, Waidyanatha S, Ramaiahgari S, Rice J, Dunlap P, Auerbach S, Mutlu E, Cristy T, Peirfelice J, DeVito M, Smith-Roe S, Rider C. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Dec 01;172(2):316-329. [ AbstractRyan K, Huang M, Ferguson S, Waidyanatha S, Ramaiahgari S, Rice J, Dunlap P, Auerbach S, Mutlu E, Cristy T, Peirfelice J, DeVito M, Smith-Roe S, Rider C. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Dec 01 ]
- Ramaiahgari S, Auerbach S, Saddler T, Rice J, Dunlap P, Sipes N, DeVito M, Shah R, Bushel P, Merrick B, Paules R, Ferguson S. The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun 01;169(2):553-566. [ AbstractRamaiahgari S, Auerbach S, Saddler T, Rice J, Dunlap P, Sipes N, DeVito M, Shah R, Bushel P, Merrick B, Paules R, Ferguson S. The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun 01 ]
- Xia M, Huang R, Shi Q, Boyd W, Zhao J, Sun N, Rice J, Dunlap P, Hackstadt A, Bridge M, Smith M, Dai S, Zheng W, Chu P, Gerhold D, Witt K, DeVito M, Freedman J, Austin C, Houck K, Thomas R, Paules R, Tice R, Simeonov A. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environmental health perspectives. 2018 Jul;126(7):077010. [ AbstractXia M, Huang R, Shi Q, Boyd W, Zhao J, Sun N, Rice J, Dunlap P, Hackstadt A, Bridge M, Smith M, Dai S, Zheng W, Chu P, Gerhold D, Witt K, DeVito M, Freedman J, Austin C, Houck K, Thomas R, Paules R, Tice R, Simeonov A. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environmental health perspectives. 2018 Jul ]