Funding Opportunity Announcements

Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)

NIEHS is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) centers. SRP center grants will support problem-based, solution-oriented research centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes research translation), data management and analysis, community engagement, research experience and training coordination, and research support functions. Collectively, the center's research projects (maximum of six) should represent a range of basic and applied research that contributes to the problem-based, solution-oriented goal of the center. Each center's central problem should be addressed by the contributions of these projects and each project should have the necessary biomedical and/or environmental science and/or engineering expertise to address the central problem. 

Deadline: October 2, 2023

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp — Clinical Trial Not Allowed)

Supports administrative supplements to recruit and support high school, undergraduate and graduate/clinical students, postbaccalaureate and post-master’s individuals, postdoctoral researchers (including health professionals), and eligible investigators. NIH encourages institutions to diversify their student, postdoctoral researchers, and faculty populations to enhance the participation of individuals from groups that are underrepresented in the biomedical, clinical, behavioral, and social sciences, such as individuals from racial and ethnic groups that have been underrepresented in the sciences; individuals with disabilities; individuals from disadvantaged backgrounds; and women from disadvantaged backgrounds. See the NIEHS workforce diversity supplements webpage for more information.

Deadlines: October 2, 2023; December 1, 2023; February 1, 2024

Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional)

ReWARD funding will support research in areas related to the programmatic interests of NIEHS and ongoing diversity, equity, inclusion, and accessibility activities focused on enhancing diversity in the biomedical research enterprise within the U.S. and territories. This funding is intended for individuals with no current NIH research project grant funding at the time of the award. This announcement requires a Plan for Enhancing Diverse Perspectives as part of the application.

Deadlines: October 5, 2023; February 5, 2024

Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed)

Supports research in environmental health science in which an event has or will imminently occur that provides a limited window of opportunity to collect samples and data to support the assessment of exposures and human health impact. The goal of the program is to characterize initial exposures, collect human biological samples, or collect human health and exposure data to provide critical information to understand exposure-health outcome relationships, with the goal of providing data that will facilitate timely action to protect public health.

Deadlines: October 8, 2023; December 1, 2023

Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)

Supports intervention research to address the impact of structural racism and discrimination on minority health and health disparities. Research projects must address structural racism and discrimination in one or more NIH-designated populations with health disparities in the U.S. and should address documented disparities in health outcomes. Applications are also expected to provide a conceptual model identifying hypothesized pathways between the structural racism and discrimination and health outcomes. NIEHS is interested in applications that are within scope of its 2018-2023 Strategic Plan, meet the criteria established in the funding opportunity, and focus on intervention research that mitigates or prevents the impacts of environmental exposures on communities due to structural racism and discrimination. Applicants are strongly encouraged to use community-engaged research approaches that ensure equity, such as including community partners as part of the research team and having letters of support from community partners. Applications that demonstrate collaborative (i.e., community-academic partnerships) intervention approaches to address the negative health effects of structural racism and discrimination across multiple populations with environmental health disparities will be prioritized.

Deadline: October 10, 2023

Community Partnerships to Advance Science for Society (ComPASS): Health Equity Research Hubs (UC2 Clinical Trial Optional)

Invites applications from eligible organizations that can serve as Health Equity Research Hubs (Hubs) for awarded community-led health equity structural intervention (CHESI) projects within the Community Partnerships to Advance Science for Society (ComPASS) Program. The Hubs will serve as a centralized research resource, providing tailored scientific, technical, and collaborative support for sustainable community engagement, research capacity building, and training to assigned CHESI projects that address social determinants of health and structural factors to improve health outcomes. The Hubs are one of three complementary initiatives under the ComPASS Program, which also include the CHESI projects and the ComPASS Coordination Center.

Letter of Intent: September 30, 2023

Deadline: October 31, 2023

Exploratory Grants for Climate Change and Health Research Center Development (P20 Clinical Trial Optional)

Solicits P20 planning grant applications for Climate Change and Health Research Centers (CCHRCs). This program will support the development of an innovative research environment to foster and sustain a transdisciplinary program of fundamental and applied research to explore the complex impacts of climate change on health and to develop action-oriented strategies that protect health and build resiliency at the individual, community, national and global levels. A major goal for this program is to build research teams as well as collaborations with communities and other key partners. The program seeks innovative research and pilot or feasibility projects that utilize transdisciplinary approaches to address questions relevant to climate change impacts on health. Applications for these CCHRCs should propose planning and development activities in preparation to build institutional research capacity for future proposals addressing climate and health.

Deadline: November 7, 2023

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)

The Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship (Parent F31) award enables promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the missions of participating NIH Institutes and Centers. The proposed mentored research training must reflect the candidate’s dissertation research project and is expected to clearly enhance the individual’s potential to develop into a productive, independent research scientist. Funding opportunities are also open for the Ruth L. Kirschstein NRSA Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30), that supports promising predoctoral students who are matriculated in a combined M.D./Ph.D. or other dual-doctoral degree training program, and who intend careers as physician/clinician-scientists, and the Ruth L. Kirschstein NRSA Individual Senior Fellowship (Parent F33), that supports experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators in research fields relevant to the missions of participating NIH Institutes and Centers.

Deadlines: December 8, 2023; April 8, 2024

PHS 2023-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)

Invites eligible United States small business concerns to submit Small Business Innovation Research (SBIR) Phase I, Phase II, Direct to Phase II (NIH only), Fast-Track (NIH only), and Phase IIB (NIH only) grant applications. The PHS 2023 -2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA represent scientific program areas that may be of interest to applicant small businesses in the development of projects that have potential for commercialization. Small business concerns that have the research capabilities and technological expertise to contribute to the research and development mission(s) of the NIH and CDC awarding components identified in this funding opportunity are encouraged to submit SBIR grant applications in these areas. A related SBIR funding opportunity is available without a clinical trial requirement: PHS 2023-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed). Related funding opportunities are available for small business applicants interested in submitting small business technology transfer (STTR) applications: PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) and PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required).

Deadlines: January 5, 2024; April 5, 2024

SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)

Encourages applications from small business concerns to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The funding opportunity aims to facilitate the transition of previously or currently funded Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance and later stage research and development not typically supported through Phase II or Phase IIB grants or contracts. This may include independent replication of key studies, Investigational New Drug-enabling studies, clinical studies, manufacturing costs, regulatory assistance, or a combination of services. Although a significant amount of the work in a CRP award may be subcontracted to other institutions, the small business concern is expected to maintain oversight and management of research and development throughout the award.

Deadlines: January 5, 2024; April 5, 2024

HHS Environmental Justice Community Innovator Challenge

The Office of the Assistant Secretary for Health and the Office of Minority Health are seeking community-led strategies and tools to address health disparities in communities disproportionately impacted by environmental risks and hazards including those related to climate change, and the cumulative impacts of other stressors. This Challenge seeks to support to community-based and Tribal organizations in areas including, but not limited to: development or implementation community-driven strategies to address health disparities; effective partnerships between community-based or Tribal organizations and other civil organizations, such as faith-based, healthcare and public health and educational organizations, to address environmental and climate change-related hazards and support community resilience; and innovative approaches to building capacity in community-based or Tribal organizations on project planning, needs assessment, budgeting, engagement with community members, and grant application writing, to address environmental and climate change-related hazards as drivers of health disparities. The competition has two phases. All eligible submissions will be evaluated, and separate prizes will be awarded for each of the two phases. The first phase is currently open for submissions. There will be a general informational webinar on October 10, and an information webinar for Tribal organizations on October 12.

Deadline: January 30, 2024

Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)

Supports research on interventions to improve health in Native American populations. This includes 1) etiologic research that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests interventions for health promotion, prevention, treatment, or recovery, and 3) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. The inclusion of Native American investigators serving on the study team or as the program director or principal investigator is strongly encouraged. This funding opportunity is part of the Intervention Research to Improve Native American Health initiative, which also includes Intervention Research to Improve Native American Health (R21 Clinical Trials Optional) and Intervention Research to Improve Native American Health (R34 Clinical Trial Optional). For the R01 and R21 funding mechanisms, NIEHS is interested in applications that focus on the development, adaptation, efficacy, effectiveness, implementation, or sustainability of culturally appropriate interventions to prevent or mitigate the health impacts of environmental exposures that disproportionately impact Native American populations. For the R34 funding mechanism, NIEHS is interested in applications that support the initial development of a culturally appropriate clinical trial or research project in preparation for health promotion or disease prevention interventions addressing the health impacts of environmental exposures that impact Native American populations.

Deadline: October 1, 2024