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Hepatitis B Virus Liver Lesions

The Digitized Atlas of Mouse Liver Lesions

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

Visit the NTP Website

(Images from Chapter 21 of Pathology of Genetically Engineered Mice (2000). JM Ward, JF Mahler, RR Maronpot, JP Sundberg, Eds. with permission of Iowa State University Press, Ames, Iowa)

Gross Liver

Gross appearance of a liver with multiple hepatic neoplasms.

Hepatocytes

Hepatitis B surface antigen in hepatocytes of an HBV transgenic mouse. Immunohistochemistry stain counterstained with hematoxylin.

Preneoplastic focus

Hepatitis B surface antigen is absent in a preneoplastic focus from an HBV transgenic mouse. Immunohistochemistry stain counterstained with hematoxylin.

Hepatocellular adenoma

Hepatocellular adenoma in an HBV transgenic mouse. Arrows indicate compression of adjacent hepatic parenchyma.

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