R code for fitting Random Periods Model
R code for fitting Random Periods Model - Software Usage Agreement and Download
Shyamal D. Peddada
National Institute of Environmental Health Sciences
Programmed by Mr. Sai Cheemalapati, Summer Intern 2011, Panther Creek High School
You may use this R code for fitting the Random Periods Model (RPM) for cell cycle genes. Since outliers and influential observations are not uncommon, the parameters of RPM are estimated using the L_1 norm. The RPM is a nonlinear model that can be used to model the expression of a cell-cycle gene over time. For details regarding the model one may refer to Liu et al. (2004).
Details on how to use is provided in the README.pdf(75KB)
Liu D, Umbach D, Peddada SD, Li L, Crockett P and Weinberg C (2004). A Random-Periods Model for Expression of Cell-Cycle Genes. Proceedings of National Academy of Sciences, 101, No. 19, 7240-7245.
Clarice R. Weinberg, Ph.D.
Acting Branch Chief, Biostatistics & Computational Biology Branch and Principal Investigator