Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Systems Toxicology Group
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Kristen Ryan, Ph.D.
Staff Scientist, Toxicologist -
Tel 984-287-3179
[email protected] -
P.O. Box 12233Mail Drop K2-12Durham, NC 27709
Kristen Ryan, Ph.D., DABT, is a toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. As a study scientist, Ryan serves as a project leader for the toxicologic and carcinogenic assessment of agents of interest to the National Toxicology Program (NTP) as well as a subject matter expert in multidisciplinary scientific teams comprised of in-house and external scientists evaluating studies on selected chemicals. She is the currently the project leader for hazard identification and characterization studies of flame retardants [e.g., tris(chloropropyl)phosphate], botanical dietary supplements [e.g., echinacea],and alkylbenzene compounds. Ryan also is a project coordinator for zebrafish-related research (SEAZIT) with the aim to enable the broader adoption of zebrafish for toxicological screening.
Ryan's research interests include examining the relationship between exposure to various chemicals in the environment and developmental neurotoxicity or neurodegeneration. She participates in activities to enhance neurotoxicity testing within the DTT through the refinement of animal models as well as evaluation various new approach methodologies for the prioritization and prediction of potential neurotoxic agents.
Ryan received a B.S. in Biology from the University of Pittsburgh in 2004 and in 2012 Ryan obtained her Ph.D. in Toxicology from the University of Colorado investigating the role of mitochondrial oxidative stress and dysfunction in progressive neurological disorders such as Parkinson's disease and Temporal Lobe Epilepsy. Upon completion of her graduate work, she obtained a post-doctoral IRTA fellowship at the DTT which was completed in 2016.
Selected Publications
- Hsieh JH, Nolte S, Hamm JT, Wang Z, Roberts GK, Schmitt CP, Ryan KR. 2023. Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a Data Analysis Pipeline for the Assessment of Developmental Toxicity with an Interlaboratory Study. Toxics. 2023 Apr 25;11(5):407. [Abstract Hsieh JH, Nolte S, Hamm JT, Wang Z, Roberts GK, Schmitt CP, Ryan KR. 2023. Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a Data Analysis Pipeline for the Assessment of Developmental Toxicity with an Interlaboratory Study. Toxics. 2023 Apr 25;11(5):407.]
- Hsieh JH, Behl M, Parham F, Ryan K. 2022. Exploring the Influence of Experimental Design on Toxicity Outcomes in Zebrafish Embryo Tests. Toxicol Sci. 2022 Jul 28;188(2):198-207. [Abstract Hsieh JH, Behl M, Parham F, Ryan K. 2022. Exploring the Influence of Experimental Design on Toxicity Outcomes in Zebrafish Embryo Tests. Toxicol Sci. 2022 Jul 28;188(2):198-207.]
- Collins B, Slade D, Aillon K, Stout M, Betz L, Waidyanatha S, Ryan K. 2022. Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed. Toxicol Rep. 2022 Mar 29;9:690-698. [Abstract Collins B, Slade D, Aillon K, Stout M, Betz L, Waidyanatha S, Ryan K. 2022. Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed. Toxicol Rep. 2022 Mar 29;9:690-698.]
- Bobst S, Ryan K, Plunkett LM, Willett KL. 2020. ToxPoint: Toxicology Studies on Δ9-tetrahydrocannabinol and Cannabidiol-containing Products Available to Consumers Are Lacking. Toxicol Sci 178(1):1-2 [Abstract Bobst S, Ryan K, Plunkett LM, Willett KL. 2020. ToxPoint: Toxicology Studies on Δ9-tetrahydrocannabinol and Cannabidiol-containing Products Available to Consumers Are Lacking. Toxicol Sci 178(1):1-2]
- Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV. 2019. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicol Sci. 2019 Dec 1;172(2):316-329. [Abstract Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV. 2019. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data. Toxicol Sci. 2019 Dec 1;172(2):316-329.]
- Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. 2016. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. Jun 23. pii: 0748233716653912. [Epub ahead of print] [Abstract Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. 2016. Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health. Jun 23. pii: 0748233716653912. [Epub ahead of print]]
- Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. 2016. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotox. Mar;53:271-81. [Abstract Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. 2016. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotox. Mar;53:271-81.]
- Waidyanatha S, Ryan KR. 2014. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica. Aug;44(8):749-56. [Abstract Waidyanatha S, Ryan KR. 2014. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica. Aug;44(8):749-56.]