Placental Cell Biology Group

Highlighted Publications

  1. Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun 12(1):6750. [Abstract Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS. 2021. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun 12(1):6750.]
  2. Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2021. Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery. Cell Rep 31(13):107837. [Abstract Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2021. Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery. Cell Rep 31(13):107837.]
  3. Guardia CM, Kane E, Tebo AG, Sanders A, Kaya D, Grogan KE. 2021. The power of peer networking for improving faculty job applications: a successful pilot program. BioRXiv. doi: 10.1101/2021.10.16.464662 [Online October 18, 2021]. [Abstract Guardia CM, Kane E, Tebo AG, Sanders A, Kaya D, Grogan KE. 2021. The power of peer networking for improving faculty job applications: a successful pilot program. BioRXiv. doi: 10.1101/2021.10.16.464662 [Online October 18, 2021].]

All Publications

  1. Guardia CM, Hierro A, Gershlick DC. 2021. Editorial: energy requirements in membrane trafficking. Front Cell Dev Biol 9:750633. [Abstract Guardia CM, Hierro A, Gershlick DC. 2021. Editorial: energy requirements in membrane trafficking. Front Cell Dev Biol 9:750633.]
  2. Nieto-Torres JL, Durgan J, Franco-Romero A, Grumati P, Guardia CM, Leidal AM, Mandell MA, Towers CG, Wang F. 2021. The Autophagy, Inflammation and Metabolism Center international eSymposium — an early-career investigators' seminar series during the COVID-19 pandemic. J Cell Sci 134(19):jcs259268. [Abstract Nieto-Torres JL, Durgan J, Franco-Romero A, Grumati P, Guardia CM, Leidal AM, Mandell MA, Towers CG, Wang F. 2021. The Autophagy, Inflammation and Metabolism Center international eSymposium — an early-career investigators' seminar series during the COVID-19 pandemic. J Cell Sci 134(19):jcs259268. ]
  3. Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. 2021. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell 32(21):ar25. [Abstract Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. 2021. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell 32(21):ar25.]
  4. Dilsizoglu Senol A, Samarani M, Syan S, Guardia CM, Nonaka T, Liv N, Latour-Lambert P, Hasegawa M, Klumperman J, Bonifacino JS, Zurzolo C. 2021. α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes. PLoS Biol 19(7):e3001287. [Abstract Dilsizoglu Senol A, Samarani M, Syan S, Guardia CM, Nonaka T, Liv N, Latour-Lambert P, Hasegawa M, Klumperman J, Bonifacino JS, Zurzolo C. 2021. α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes. PLoS Biol 19(7):e3001287.]
  5. Saric A, Freeman SA, Williamson CD, Jarnik M, Guardia CM, Fernandopulle MS, Gershlick DC, Bonifacino JS. 2021. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun 12(1):4552. [Abstract Saric A, Freeman SA, Williamson CD, Jarnik M, Guardia CM, Fernandopulle MS, Gershlick DC, Bonifacino JS. 2021. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun 12(1):4552. ]
  6. Guardia CM, Christenson ET, Zhou W, Tan XF, Lian T, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. The structure of human ATG9A and its interplay with the lipid bilayer. Autophagy 16(12):2292-2293. [Abstract Guardia CM, Christenson ET, Zhou W, Tan XF, Lian T, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A. 2020. The structure of human ATG9A and its interplay with the lipid bilayer. Autophagy 16(12):2292-2293.]
  7. Guardia CM, De Pace R, Sen A, Saric A, Jarnik M, Kolin DA, Kunwar A, Bonifacino JS. 2019. Reversible association with motor proteins (RAMP): a streptavidin-based method to manipulate organelle positioning. PLoS Biol 17(5):e3000279. [Abstract Guardia CM, De Pace R, Sen A, Saric A, Jarnik M, Kolin DA, Kunwar A, Bonifacino JS. 2019. Reversible association with motor proteins (RAMP): a streptavidin-based method to manipulate organelle positioning. PLoS Biol 17(5):e3000279.]
  8. Sharma G, Guardia CM, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML. 2019. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy 15(10):1694-1718. [Abstract Sharma G, Guardia CM, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML. 2019. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy 15(10):1694-1718.]
  9. Guardia CM, De Pace R, Mattera R, Bonifacino JS. 2018. Neuronal functions of adaptor complexes involved in protein sorting. Curr Opin Neurobiol 51:103-110. [Abstract Guardia CM, De Pace R, Mattera R, Bonifacino JS. 2018. Neuronal functions of adaptor complexes involved in protein sorting. Curr Opin Neurobiol 51:103-110.]
  10. Mattera R, Park SY, De Pace R, Guardia CM, Bonifacino JS. 2017. AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation. Proc Natl Acad Sci U S A 114(50):E10697-E10706. [Abstract Mattera R, Park SY, De Pace R, Guardia CM, Bonifacino JS. 2017. AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation. Proc Natl Acad Sci U S A 114(50):E10697-E10706.]
  11. Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS. 2017. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy 13(10):1648-1663. [Abstract Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS. 2017. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy 13(10):1648-1663.]
  12. Farías GG, Guardia CM, De Pace R, Britt DJ, Bonifacino JS. 2017. BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon. Proc Natl Acad Sci U S A 114(14):E2955-E2964. [Abstract Farías GG, Guardia CM, De Pace R, Britt DJ, Bonifacino JS. 2017. BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon. Proc Natl Acad Sci U S A 114(14):E2955-E2964.]
  13. Pu J, Guardia CM, Keren-Kaplan T, Bonifacino JS. 2016. Mechanisms and functions of lysosome positioning. J Cell Sci 129(23):4329-4339. [Abstract Pu J, Guardia CM, Keren-Kaplan T, Bonifacino JS. 2016. Mechanisms and functions of lysosome positioning. J Cell Sci 129(23):4329-4339.]
  14. Guardia CM, Farías GG, Jia R, Pu J, Bonifacino JS. 2016. BORC functions upstream of kinesins 1 and 3 to coordinate regional movement of lysosomes along different microtubule tracks. Cell Rep 17(8):1950-1961. [Abstract Guardia CM, Farías GG, Jia R, Pu J, Bonifacino JS. 2016. BORC functions upstream of kinesins 1 and 3 to coordinate regional movement of lysosomes along different microtubule tracks. Cell Rep 17(8):1950-1961. ]
  15. Britt DJ, Farías GG, Guardia CM, Bonifacino JS. 2016. Mechanisms of polarized organelle distribution in neurons. Front Cell Neurosci 10:88. [Abstract Britt DJ, Farías GG, Guardia CM, Bonifacino JS. 2016. Mechanisms of polarized organelle distribution in neurons. Front Cell Neurosci 10:88.]
  16. Farías GG, Guardia CM, Britt DJ, Guo X, Bonifacino JS. 2015. Sorting of dendritic and axonal vesicles at the pre-axonal exclusion zone. Cell Rep 13(6):1221-1232. [Abstract Farías GG, Guardia CM, Britt DJ, Guo X, Bonifacino JS. 2015. Sorting of dendritic and axonal vesicles at the pre-axonal exclusion zone. Cell Rep 13(6):1221-1232.]
  17. Mattera R, Guardia CM, Sidhu SS, Bonifacino JS. 2015. Bivalent motif-ear interactions mediate the association of the accessory protein tepsin with the AP-4 adaptor complex. J Biol Chem 290(52):30736-30749. [Abstract Mattera R, Guardia CM, Sidhu SS, Bonifacino JS. 2015. Bivalent motif-ear interactions mediate the association of the accessory protein tepsin with the AP-4 adaptor complex. J Biol Chem 290(52):30736-30749. ]
  18. Guardia CM, Caramelo JJ, Trujillo M, Méndez-Huergo SP, Radi R, Estrin DA, Rabinovich GA. 2014. Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 4(5):428-441. [Abstract Guardia CM, Caramelo JJ, Trujillo M, Méndez-Huergo SP, Radi R, Estrin DA, Rabinovich GA. 2014. Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 4(5):428-441.]
  19. Zeida A, Guardia CM, Lichtig P, Perissinotti LL, Defelipe LA, Turjanski A, Radi R, Trujillo M, Estrin DA. 2014. Thiol redox biochemistry: insights from computer simulations. Biophys Rev 6(1):27-46. [Abstract Zeida A, Guardia CM, Lichtig P, Perissinotti LL, Defelipe LA, Turjanski A, Radi R, Trujillo M, Estrin DA. 2014. Thiol redox biochemistry: insights from computer simulations. Biophys Rev 6(1):27-46.]
  20. Di Lella S, Sundblad V, Cerliani JP, Guardia CM, Estrin DA, Vasta GR, Rabinovich GA. 2011. When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50(37):7842-7857. [Abstract Di Lella S, Sundblad V, Cerliani JP, Guardia CM, Estrin DA, Vasta GR, Rabinovich GA. 2011. When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50(37):7842-7857.]
  21. Guardia CM, Gauto DF, Di Lella S, Rabinovich GA, Martí MA, Estrin DA. 2011. An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network. J Chem Inf Model 51(8):1918-1930. [Abstract Guardia CM, Gauto DF, Di Lella S, Rabinovich GA, Martí MA, Estrin DA. 2011. An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network. J Chem Inf Model 51(8):1918-1930.]
  22. Di Lella S, Martí MA, Croci DO, Guardia CM, Díaz-Ricci JC, Rabinovich GA, Caramelo JJ, Estrin DA. 2010. Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria. Biochemistry 49(35):7652-7658. [Abstract Di Lella S, Martí MA, Croci DO, Guardia CM, Díaz-Ricci JC, Rabinovich GA, Caramelo JJ, Estrin DA. 2010. Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria. Biochemistry 49(35):7652-7658.]
  23. Gauto DF, Di Lella S, Guardia CM, Estrin DA, Martí MA. 2009. Carbohydrate-binding proteins: dissecting ligand structures through solvent environment occupancy. J Phys Chem B 113(25):8717-8724. [Abstract Gauto DF, Di Lella S, Guardia CM, Estrin DA, Martí MA. 2009. Carbohydrate-binding proteins: dissecting ligand structures through solvent environment occupancy. J Phys Chem B 113(25):8717-8724.]
  24. Guardia CMA, González Lebrero MC, Bari SE, Estrin DA. 2008. QM/MM investigation of the reaction products between nitroxyl and O2 in aqueous solution. Chem Phys Lett 463:112-116. [Abstract Guardia CMA, González Lebrero MC, Bari SE, Estrin DA. 2008. QM/MM investigation of the reaction products between nitroxyl and O2 in aqueous solution. Chem Phys Lett 463:112-116.]