Immunogenetics

  1. Whitehead GS, Thomas SY, Nakano K, Royer DJ, Burke CG, Nakano H, Cook DN. 2022. A neutrophil/TGF-β axis limits the pathogenicity of allergen-specific CD4+ T cells. JCI Insight. 7(4):e150251. doi:10.1172/jci.insight.150251. [Abstract Whitehead GS, Thomas SY, Nakano K, Royer DJ, Burke CG, Nakano H, Cook DN. 2022. A neutrophil/TGF-β axis limits the pathogenicity of allergen-specific CD4+ T cells. JCI Insight. 7(4):e150251. doi:10.1172/jci.insight.150251.]
  2. Izumi G, Nakano H, Nakano K, Whitehead GS, Grimm SA, Fessler MB, Karmaus PW, Cook DN. 2021. CD11b + lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation. Nat Commun 12(1):5029. [Abstract Izumi G, Nakano H, Nakano K, Whitehead GS, Grimm SA, Fessler MB, Karmaus PW, Cook DN. 2021. CD11b + lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation. Nat Commun 12(1):5029.]
  3. Karcz TP, Whitehead GS, Nakano K, Nakano H, Grimm SA, Williams JG, Deterding LJ, Jacobson KA, Cook DN. 2021. UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia. J Clin Invest; doi: 10.1172/JCI140709 [Online 1 April 2021]. [Abstract Karcz TP, Whitehead GS, Nakano K, Nakano H, Grimm SA, Williams JG, Deterding LJ, Jacobson KA, Cook DN. 2021. UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia. J Clin Invest; doi: 10.1172/JCI140709 [Online 1 April 2021].]
  4. Whitehead GS, Kang HS, Thomas SY, Medvedev A, Karcz TP, Izumi G, Nakano K, Makarov SS, Nakano H, Jetten AM, Cook DN. Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist. JCI Insight. 2019 Jun 11;5. pii: 125528. doi: 10.1172/jci.insight.125528. PMID: 31184998. [Abstract Whitehead GS, Kang HS, Thomas SY, Medvedev A, Karcz TP, Izumi G, Nakano K, Makarov SS, Nakano H, Jetten AM, Cook DN. Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist. JCI Insight. 2019 Jun 11;5. pii: 125528. doi: 10.1172/jci.insight.125528. PMID: 31184998.]
  5. Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN. MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens. Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.84. [Epub ahead of print] [Abstract Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN. MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens. Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.84. [Epub ahead of print]]
  6. Whitehead GS, Thomas SY, Shalaby KH, Nakano K, Moran TP, Ward JM, Flake GP, Nakano H and Cook DN. TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation. J Clin Invest. 2017 Sep 1;127(9):3313-3326. doi: 10.1172/JCI90890. Epub 2017 Jul 31. PMID: 28758900 [Abstract Whitehead GS, Thomas SY, Shalaby KH, Nakano K, Moran TP, Ward JM, Flake GP, Nakano H and Cook DN. TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation. J Clin Invest. 2017 Sep 1;127(9):3313-3326. doi: 10.1172/JCI90890. Epub 2017 Jul 31. PMID: 28758900]
  7. Nakano H, Moran TP, Nakano K, Gerrish KE, Bortner CD, Cook DN. Complement Receptor C5aR1/CD88 and Dipeptidyl Peptidase-4/CD26 Define Distinct Hematopoietic Lineages of Dendritic Cells. Journal of Immunology 2015 194(8):3808-3819. [Abstract Nakano H, Moran TP, Nakano K, Gerrish KE, Bortner CD, Cook DN. Complement Receptor C5aR1/CD88 and Dipeptidyl Peptidase-4/CD26 Define Distinct Hematopoietic Lineages of Dendritic Cells. Journal of Immunology 2015 194(8):3808-3819.]
  8. Nakano H, Burgents J, Nakano K, Whitehead G, Cheong C, Bortner C, Cook D. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunology 6(4):678-691, 2013. [Abstract Nakano H, Burgents J, Nakano K, Whitehead G, Cheong C, Bortner C, Cook D. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunology 6(4):678-691, 2013.]
  9. Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN. The TLR5 ligand, bacterial flagellin, promotes asthma by priming allergic responses to indoor allergens. Nat Med. Nov;18(11):1705-10, 2012. [Abstract Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN. The TLR5 ligand, bacterial flagellin, promotes asthma by priming allergic responses to indoor allergens. Nat Med. Nov;18(11):1705-10, 2012.]
  10. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30. Epub 2009 Aug 6. [Abstract Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30. Epub 2009 Aug 6.]